Secrecy Performance Maximization for Underlay CR Networks with an Energy Harvesting Jammer.

This paper investigates the secrecy communication in an underlay cognitive radio (CR) networks with one primary user (PU) as well as multiple PUs, where the radio frequency (RF) energy-harvesting secondary user (SU) transmits the confidential information to the destination in the presence of a potential eavesdropper. We introduce a RF energy-harvesting secondary jammer (SJ) to secure the SU transmissions. The system works in time slots, where each time slot is divided into the energy transfer (ET) phase and the information transfer (IT) phase.

Impact of abiraterone acetate plus prednisone in patients with castration-sensitive prostate cancer and visceral metastases over four years of follow-up: A post-hoc exploratory analysis of the LATITUDE study.

Background: A post-hoc analysis of the phase-3 LATITUDE study assessed the impact of abiraterone acetate plus prednisone (AA+P) on overall survival (OS) and radiographic progression-free survival (rPFS) in men with metastatic castration-sensitive prostate cancer (mCSPC) and visceral metastases (VM).

Methods: Newly diagnosed mCSPC patients were randomized (1:1) to AA+P and androgen deprivation therapy (ADT) or placebo+ADT. Patients with VM in liver or lungs with or without other soft tissue and bone metastases (based on CT/MRI) at baseline were analyzed, after 51.

Health-Related Quality of Life in Metastatic, Hormone-Sensitive Prostate Cancer: ENZAMET (ANZUP 1304), an International, Randomized Phase III Trial Led by ANZUP.

Purpose: We previously reported that enzalutamide improved overall survival when added to standard of care in metastatic, hormone-sensitive prostate cancer. Here, we report its effects on aspects of health-related quality of life (HRQL).

Methods: HRQL was assessed with the European Organisation for Research and Treatment of Cancer core quality-of-life questionnaire and QLM-PR25 at weeks 0, 4, 12, and then every 12 weeks until progression.

Needs Assessment and System Design of an Extracorporeal Membrane Oxygenation Simulation Learning System.

Nurses require training to manage extracorporeal membrane oxygenation (ECMO). Thus, the aim of this study is to investigate intensive care unit nurse needs and design an ECMO simulation learning system. A systemic needs analysis included interviews and a literature review.

Concurrent granulomatous mastitis and invasive ductal cancer in contralateral breasts-a case report and review.

Idiopathic granulomatous mastitis (GM) is an uncommon chronic benign disease of the breast that is challenging to clinically distinguish from malignancy. However, it is unusual to diagnose GM concurrently with carcinoma in the same breast and rarer still to encounter GM and malignancy in contralateral breasts. We describe the case of a 39-year-old female who presented with right multifocal breast cancer and left granulomatous mastitis, discuss complexities in her management plan and review the literature on this unusual concurrent condition.

A phase 1 study to assess the safety, pharmacokinetics, and anti-tumor activity of the androgen receptor n-terminal domain inhibitor epi-506 in patients with metastatic castration-resistant prostate cancer.

Background: EPI-506 is the first of a new class of drugs targeting the N-terminal domain (NTD) of the androgen receptor (AR), potentially overcoming known resistance mechanisms to androgen receptor pathway inhibitors (ARPIs) among men with metastatic castration resistant prostate cancer (mCRPC).

Methods: Patients with mCRPC who had progressed on prior ARPI were enrolled in this phase 1 open-label, adaptive 3 + 3 dose escalation study. The primary outcome was safety and tolerability of oral EPI-506.

Study the Use of Activated Carbon and Bone Char on the Performance of Gravity Sand-Bag Water Filter.

In this study, granulated activated charcoal (GAC) and bio charcoal (BC) is used as a filler in P3 biosand bag filter to study their filtration performance against a range of fluoride impurities from 1-1400 mg/L. A set of experiments are done to analyze the filtration efficiency of the sandbag filter against fluoride impurities after incorporating different amounts (e.g.

New taxa of tribe Gastrodieae (Epidendroideae, Orchidaceae) from Yunnan, China and its conservation implication.

, a new species of Orchidaceae from Yunnan Province, China, is described and illustrated. It is morphologically similar to , but can be easily distinguished from the latter by having a rhombic epichile, long column (6.0-7.

Finding the optimal treatment sequence in metastatic castration-resistant prostate cancer-a narrative review.

Over the last two decades, there has been significant progress in the treatment of metastatic prostate cancer. Multiple treatments with diverse mechanisms of action have improved clinical outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC) including taxane chemotherapy, immunotherapy, potent androgen receptor pathway inhibitors (ARPI), and radiopharmaceuticals (radium-223). As these treatments have entered standard clinical practise, clinicians have been challenged on how to optimally select and sequence them as the landmark studies establishing their efficacy had control arms with placebo or minimally effective therapy and there is a paucity of prospective trials examining treatment sequencing.

Integrated Gait Triggered Mixed Reality and Neurophysiological Monitoring as a Framework for Next-Generation Ambulatory Stroke Rehabilitation.

Brain stroke affects millions of people in the world every year, with 50 to 60 percent of stroke survivors suffering from functional disabilities, for which early and sustained post-stroke rehabilitation is highly recommended. However, approximately one third of stroke patients do not receive early in hospital rehabilitation programs due to insufficient medical facilities or lack of motivation. Gait triggered mixed reality (GTMR) is a cognitive-motor dual task with multisensory feedback tailored for lower-limb post-stroke rehabilitation, which we propose as a potential method for addressing these rehabilitation challenges.

Chemically and temporally resolved oxidative potential of urban fine particulate matter.

Vehicle emissions are an important source of particulate matter (PM) in urban areas and have well-known adverse health effects on human health. Oxidative potential (OP) is used as a quantification metric for indexing PM toxicity. In this study, by using a liquid spot sampler (LSS) and the dithiothreitol (DTT) assay, the diurnal OP variation was assessed at a ground-level urban monitoring station.

Immediate Effect of Whole Body Vibration on Knee Extensor Tendon Stiffness in Hemiparetic Stroke Patients.

Whole body vibration is widely used to enhance muscle performance, but evidence of its effects on the tendon stiffness of the knee extensor tendon in stroke remains inconclusive. Our study was aimed to determine the difference in patellar and quadriceps tendon stiffness between hemiparetic and unaffected limbs in stroke patients and to investigate the immediate effect of whole body vibration on tendon stiffness. The patellar and quadriceps tendon stiffness of first-ever hemiplegic stroke patients was evaluated with elastography to compare the differences between hemiparetic and unaffected limbs.

Characteristics of PM and PAHs emitted from a coal-fired boiler and the efficiencies of its air pollution control devices.

Sampling and analysis of filterable particulate matter (FPM), FPM, condensable particulate matter (CPM), polycyclic aromatic hydrocarbons (PAHs), sulfur oxides (SO), and nitrogen oxides (NO) emitted from a coal-fired boiler equipped with selective catalytic reduction (SCR)+ electrostatic precipitator (ESP) + wet flue gas desulfurization (WFGD) + wet electrostatic precipitator (WESP) as air pollution control devices (APCDs) are conducted. The results show that NO concentration emitted from the coal-fired boiler is 56 ± 2.17 ppm (with the NO removal efficiency of 47.

Mobile Two-Way Molecular Communication via Diffusion Using Amplify-and-Forward and Analog Network Coding.

Mobile molecular communication via diffusion (MCvD) has attracted lots of attentions due to its time-varying channels. In this paper, we investigate a mobile two-way MCvD model, which consists of two mobile source nanomachines and a mobile relay nanomachine. The amplify-and-forward (AF) relaying and analog network coding (ANC) are utilized to implement the exchange of information between two source nanomachines in this model.

Controlled Growth of Porous InBr: PbBr Film for Preparation of CsPbBr in Carbon-Based Planar Perovskite Solar Cells.

Due to the low solubility of CsBr in organic solvents, the CsPbBr film prepared by the multi-step method has holes and insufficient thickness, and the light absorption capacity and current density of the perovskite film hinder the further improvement in the power conversion efficiency (PCE) of CsPbBr solar cells. In this study, we introduced InBr into the PbBr precursor solution and adjusted the concentration of PbBr, successfully prepared PbBr with a porous structure on the compact TiO (c-TiO) substrate to ensure that it fully reacted with CsBr, and obtained the planar carbon-based CsPbBr solar cells with high-quality perovskite film. The results reveal that the porous PbBr structure and the increasing PbBr concentration are beneficial to increase the thickness of the CsPbBr films, optimize the surface morphology, and significantly enhance the light absorption capacity.

Use of real-time PCR as an alternative to conventional genotyping methods for the laboratory detection of lymphogranuloma venereum (LGV).

Lymphogranuloma venereum (LGV) can be differentiated from non-LGV chlamydial infection using Sanger sequencing or molecular assays, including those that are commercially-available internationally. Here, we describe the performance of a rapid real-time PCR (RT-PCR)-based strategy in differentiating Chlamydia trachomatis infections associated with LGV or non-LGV serovars. One hundred three rectal swabs, previously genotyped using Sanger sequencing of the ompA gene as a reference method, were tested in the RT-PCR assays.

Safety and Efficacy of Roxadustat for Anemia in Patients With Chronic Kidney Disease: A Meta-Analysis and Trial Sequential Analysis.

Roxadustat, a hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI), has been used to treat anemia in patients with chronic kidney disease (CKD). However, its safety and efficacy remain controversial. The PubMed, EMBASE, Science Citation Index, Cochrane Central Register of Controlled Trials, and Clinical Trial Registries databases were searched for relevant studies published up to April 2021.

Artificial intelligence-assisted system for precision diagnosis of PD-L1 expression in non-small cell lung cancer.

Standardized programmed death-ligand 1 (PD-L1) assessment in non-small cell lung cancer (NSCLC) is challenging, owing to inter-observer variability among pathologists and the use of different antibodies. There is a strong demand for the development of an artificial intelligence (AI) system to obtain high-precision scores of PD-L1 expression in clinical diagnostic scenarios. We developed an AI system using whole slide images (WSIs) of the 22c3 assay to automatically assess the tumor proportion score (TPS) of PD-L1 expression based on a deep learning (DL) model of tumor detection.

Improving persistent luminescence in pressure-tuned CsPbBr nanocrystals by Ce doping.

The pressure-dependent photoluminescence kinetics of CsPbBr:Ce quantum dots was investigated by steady-state and time-resolved photoluminescence spectroscopy. Here, we propose a novel strategy to improve the persistent luminescence of CsPbBr quantum dots under high pressure through doping of Ce ions. Under high pressure, the peak intensity and energy of CsPbBr:Ce quantum dots decreased more slowly than those of CsPbBr quantum dots, which is manifested by pressure coefficient reductions of 0.

Heterogeneity of programmed death-ligand 1 expression and infiltrating lymphocytes in paired resected primary and metastatic non-small cell lung cancer.

Metastatic tumors (MTs) may show different characteristics of the immune microenvironment from primary tumors (PTs) in non-small cell lung cancer (NSCLC). The heterogeneity of immune markers in metastatic NSCLC and its associated factors has not been well demonstrated. In this study, 64 surgically resected specimens of paired PTs and MTs were obtained from 28 patients with NSCLC.

Timing of Adjuvant Radiotherapy After Keloid Excision: A Systematic Review and Meta-Analysis.

Background: No consensus exists regarding the appropriate timing of adjuvant radiotherapy administration after surgical excision of keloids.

Objective: This study investigated the appropriate timing of adjuvant radiotherapy.

Materials And Methods: A systematic review and meta-analysis of randomized controlled trials and observational cohort studies was performed.