Publications by authors named "Chi Ho Chong"
LRRC7 has been identified as a candidate gene for severe childhood emotional dysregulation. Direct experimental evidence for a role of LRRC7 in the disease is needed, as is a better understanding of its impact on neuronal structure and signaling, and hence potential treatment targets. Here, we generated and analyzed an Lrrc7 mutant mouse line.
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- TSPYL2 is an X-linked gene linked to neurodevelopmental disorders, and knockout studies in mice showed it plays a role in learning and sensorimotor functions.
- TSPYL2 interacts with EZH2, a methyltransferase, and regulates gene expression by affecting H3K27 trimethylation levels in the hippocampus.
- Specific gene expression levels were altered in TSPYL2 knockout mice, indicating that TSPYL2 is crucial for the maturation and proper function of neurons by enhancing the expression of key developmental genes.