Isolation and antibacterial activity of anomanol B and other secondary metabolites from the stem bark of (Annonaceae).

A new Lanosta-7,9(11),22-trien-3,15,20-triol named Anomanol B together with five known compounds: manniindole , arborinine , polycarpol 8,9-dimethoxyphenanthridin-6(5)-one and 3-O--D-glucopyranosyl--sitosterol were isolated from the stem bark extract of by routine chromatography techniques. 8,9-dimethoxyphenanthridin-6(5)-one was reported from natural origin for the first time. The structures of the compounds were established by comprehensive elucidation of spectroscopic data and by comparison with literature data.

The Effects of Tormentic Acid and Extracts from on and Growth and Inhibition of Ergosterol Biosynthesis in .

and are the leading causes of human fungal infections worldwide. There is an increase in resistance of pathogens to existing antifungal drugs leading to a need to find new sources of antifungal agents. Tormentic acid has been isolated from different plants including and has been found to possess antimicrobial properties, including antifungal activity.

Antibiofilm Activity of Extract and a Compound Isolated from against .

has been used as a traditional medicine in Africa. It is documented as a rich source of phytochemicals with antibacterial activities. To further explore the antibacterial potential of these phytochemical components, the phytochemical profile of the dichloromethane: methanol leaf extract from .

Two new sphingolipids from the stem bark of .

commonly known as Bang Bali in Bali-Nguemba, Cameroon is used in traditional medicine against various diseases. The leaves and stem bark extracts were subjected to silica gel and Sephadex LH column chromatography to yield pure compounds. The structures of the compounds were determined by detail analysis of NMR and Mass spectroscopic data and by comparison with data reported in the literature.

Isolation and Antimicrobial Activities of Phytochemicals from (Chrysobalanaceae).

The widespread use of antimicrobial agents to treat infectious diseases has led to the emergence of antibiotic resistant pathogens. Plants have played a central role in combating many ailments in humans, and has been used for medicinal purposes. Seven extracts from leaves were prepared using serial exhaustive extraction of nonpolar to polar solvents.

The Effects of Combining Cancer Drugs with Compounds Isolated from Sond. and Welw. ex M.A. Lawson (Combretaceae) on the Viability of Jurkat T Cells and HL-60 Cells.

and have been shown to have anticancer, antibacterial, antituberculosis, and antifungal effects in both and studies. This study sought to evaluate the antiproliferative effects of compounds isolated from and on Jurkat T and HL-60 cancer cell lines in combination with doxorubicin and/or chlorambucil. At their GI concentrations, the isolated compounds were combined with the corresponding GI of chlorambucil and doxorubicin.

Ethnomedicinal uses, phytochemistry, and pharmacology of the genus Vepris (Rutaceae): A review.

Ethnopharmacological Relevance: Species of the genus Vepris are used in traditional African pharmacopeia for the treatment of various conditions, including chronic diseases and other parasitic. Further uses are against whooping cough and colic in children and as an antidote against snakebite. Data presented will enable the interested scientists to work on this genus applying the so-called "ethnopharmacologic approach", which may lead towards the discovery of the effective, safe plant medicinal products.

Steroidal saponins from Raphia vinifera and their cytotoxic activity.

Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1-4), along with six known secondary metabolites (6-10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Among the compounds tested, 1 and 4 showed the most promising cytotoxic activity against the drug-sensitive CCRF-CEM leukemia cell lines, with IC values of 3.

A phenanthridin-6()-one derivative and a lanostane-type triterpene with antibacterial properties from (Oliv). Engl. & Diels (Annonaceae).

The chemical investigation of root extract by column chromatography techniques led to the isolation of eight compounds among which two previously unreported compounds; a lanostane-type triterpene, lanosta-7,9(11),23-triene-3β,15α-diol and an alkaloid, 9-hydroxy-8-methoxyphenanthridin-6()-one along with six known compounds: lanosta-7,9(11),24-triene-3β,21-diol , oxoanolobine , 3, 4-dihydroxybenzoic acid stigmasterol βsitosterol and 3-O-β-D-glucopyranosyl-β-stigmasterol Their structures were established from spectral data, mainly HR-ESIMS, 1 D and 2 D NMR and by comparison with literature data. The crude root and stem bark extracts (AMR and AMB) and the isolated compounds () were tested against nine Gram-negative bacteria using rapid -iodonitrotetrazolium chloride ≥97% (INT) microdilution technique. It was found that AMR, AMB and compound were active against the nine tested bacteria with MIC values ranging from 64 to 1024 µg/mL.