Construction of Alkaloid-Type Bis Carbazoles via Pd(II)-Catalyzed C-H Functionalization.

We report the construction of unsymmetrical dimeric carbazoles and π-extended bis carbazoles (having an aryl ring spacer) via the C-H functionalization route. Generally, oxidative coupling and traditional cross-coupling reactions have been used to construct bis- and π-extended carbazoles. Natural bis carbazole alkaloids and synthetic dimeric carbazoles are important molecules in medicinal, materials chemistry research.

Clinicopathological Characteristics of Multiple Primary Malignancies Involving Female Genital Tract at a Tertiary Cancer Institute of Northeast India.

Background: The term "Multiple Primary Malignant Neoplasms (MPMNs)" refers to two or more unrelated primary malignant neoplasms that originate from single or different organs and occur in one patient. MPMNs have been divided into synchronous and metachronous based on time duration after first malignancy.

Materials And Methods: This was a hospital-based retrospective study conducted at a tertiary cancer institute in Northeast India.

Exploring the efficacy of various CNN architectures in diagnosing oral cancer from squamous cell carcinoma.

Unlabelled: Oral cancer can result from mutations in cells located in the lips or mouth. Diagnosing oral cavity squamous cell carcinoma (OCSCC) is particularly challenging, often occurring at advanced stages. To address this, computer-aided diagnosis methods are increasingly being used.

Strain induced crystal lattice softening and improved thermoelectric performance of hydrogenated silicene for energy harvesting applications.

In recent years, Silicene has attracted great interest in various fields but does not fit well in the field of thermoelectrics due to the absence of electronic band gap. Nevertheless, hydrogenation of silicene (SiH) delocalize the free electrons and induces gap widening (2.19 eV), but its thermoelectric performance is still limited due to the larger band gap.

Unraveling the genetic diversity, population structure, and stability for yield-related traits of rice genotypes in mid-hills of northeastern India.

The cultivation of nearly 10,000 indigenous rice landraces in the North-Eastern Hill (NEH) region by various ethnic groups creates opportunities for the utilization of unique landraces through systematic evaluation of genetic variability. In the present study, a set of 102 rice landraces were assessed based on morphological and SSR markers, and five checks in augmented design vis-à-vis high-yielding rice genotypes with stable performance were identified. The presence of high estimates of heritability, genotypic coefficient of variation, and genetic advance over mean indicated the predominance of additive gene action, which necessitated the effectiveness of selection in augmenting productivity.

Early onset fulminant neonatal sepsis and multiple serous effusions caused by in an extremely preterm neonate.

is a Gram-negative bacterium commonly isolated from environmental sources such as plants and soil. Infections in humans are usually reported following penetrating wounds or in hospital settings due to contaminated medical equipment. Neonatal sepsis caused by this organism is rare.

Cortical hypoactivation of frontal areas modulate resting EEG microstates in children with ADHD.

Background: The present study examined EEG microstate alterations and their neural generators during resting state in children with ADHD to explore a potential state biomarker.

Methods: A total of seventy-six participants, thirty-eight each, combined type ADHD, and neurotypical children (NC) participated in the study. Five-minute resting (eyes open) 128 channel eeg data were acquired and two-minute clean EEG data were analyzed for microstates, its sources and connectivity in both the groups.

The role of CD95 in modulating CAR T-cell therapy: Challenges and therapeutic opportunities in oncology.

CAR T cell therapy has revolutionized how we deliver cancer treatment, most notably for hematologic cancers, by compelling T cells to recognize and kill tumor cells. Nevertheless, current obstacles to utilizing this therapy in solid tumors and overcoming cancer resistance include radicalization. This review discusses how CD95 modulation can boost CAR T cell efficacy.

Association of hTERT MNS16A polymorphism with clinical outcomes of North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.

Background: Telomerase has been linked to aging and cancer. The MNS16A polymorphism in the hTERT gene plays a significant role in modulating telomerase activity and highlights the complexity of telomere-related genetics in cancer research.

Experimental Design: We genotyped 401 lung-cancer samples treated with platinum-based chemotherapy to identify the MNS16A polymorphism.

Perception of First-Year MBBS Students Toward Virtual Dissection in Learning Anatomy: A Comparative Study Between High and Low Academic Achievers.

Introduction Anatomy, as a crucial subject in the medical curriculum, demands continuous efforts to adopt innovative teaching methods to make it a student-friendly subject. One of the new educational technologies is the virtual anatomy dissection. This high-tech tool allows students to perform some hands-on manipulation of a digital cadaver through an electronic screen in the form of a table.

Possible Factor Xa Resistance in a Patient Who Failed Apixaban and Rivaroxaban.

This article aims to discuss the literature on switching to an anticoagulant with a different mechanism of action in case of treatment failure. We present a patient with atrial fibrillation who incurred an embolic stroke despite adequate anticoagulation with apixaban and developed a new symptomatic ischemic stroke during the same admission after switching to rivaroxaban, a factor Xa inhibitor with a similar mechanism of action. He had no new events at 3-months after switching to dabigatran, a direct thrombin inhibitor.

Novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma.

Multiple myeloma (MM) is a clonal plasma cell proliferative malignancy characterized by a debilitating bone disease. Osteolytic destruction, a hallmark of MM, is driven by increased osteoclast number and exacerbated bone resorption, primarily fueled by the excessive production of RANKL, the master regulator of osteoclast formation, within the tumor niche. We previously reported that osteocytes, the most abundant cells in the bone niche, promote tumor progression and support MM bone disease by overproducing RANKL.

Advancements in Exosome Proteins for Breast Cancer Diagnosis and Detection: With a Focus on Nanotechnology.

Breast cancer, a leading cause of mortality among women, has been recognized as requiring improved diagnostic methods. Exosome proteins, found in small extracellular vesicles, have emerged as a promising solution, reflecting the state of their cell of origin and playing key roles in cancer progression. This review examines their potential in breast cancer diagnosis, discussing advanced isolation and characterization techniques such as ultracentrifugation and microfluidic-based approaches.

Sub-2-cycle post-compression of multi-mJ energy Ti:sapphire laser pulses in a gas-filled multi-pass cell.

We report on the nonlinear temporal post-compression of 7 mJ sub-40 fs pulses from a commercial kHz Ti:sapphire laser down to a record 3.8 fs duration (sub-1.5 optical cycle) in a compact single-stage gas-filled multi-pass cell (MPC), with 60% overall compression efficiency.

Correction: Psychological distress and burnout among healthcare worker during COVID-19 pandemic in India-A cross-sectional study.

[This corrects the article DOI: 10.1371/journal.pone.

Gaming-Based Tele-Exercise Program to Improve Physical Function in Frail Older Adults: Feasibility Randomized Controlled Trial.

Background: Frailty leads to reduced physical activity can cause increased fall risk. This contributes to accelerated aging processes, leading to adverse health outcomes and reduced quality of life. We have developed and piloted the design, usability, safety, and feasibility of a gaming-based cognitive-motor (CogXergaming) tele-exercise protocol in prefrail older adults.

Correction: Kaur, M.; Menon, C. Submillimeter Sized 2D Electrothermal Optical Fiber Scanner. 2023, , 404.

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