A new portable penetrometer for measuring the viscosity of active lava.

Viscosity is a fundamental physical property of lava that dictates style and rate of effusive transport. Studies of lava viscosity have predominantly focused on measuring re-melted rocks in the laboratory. While these measurements are well-constrained in temperature, shear rate, and oxygen fugacity, they cannot reproduce the complexities of the natural emplacement environment.

A new portable field rotational viscometer for high-temperature melts.

Mounted on top of furnaces, laboratory viscometers can be used for the rheological characterization of high temperature melts, such as molten rocks (lava). However, there are no instruments capable of measuring the viscosity of large volumes of high temperature melts outside the laboratory at, for example, active lava flows on volcanoes or at industrial sites. In this article, we describe a new instrument designed to be easy to operate, highly mobile, and capable of measuring the viscosity of high temperature liquids and suspensions (<1350 °C).

Reappraisal of gap analysis for effusive crises at Piton de la Fournaise.

Unlabelled: Effective and rapid effusive crisis response is necessary to mitigate the risks associated with lava flows that could threaten or inundate inhabited or visited areas. At Piton de la Fournaise (La Réunion, France), well-established protocols between Observatoire Volcanologique du Piton de la Fournaise - Institut de Physique du Globe de Paris (OVPF-IPGP) and civil protection, and between scientists of a multinational array of institutes, allow effective tracking of eruptive crises and hazard management embracing all stakeholders. To assess the outstanding needs for such responses Tsang and Lindsay (J Appl Volcanol 9:9, 2020) applied a gap analysis to assess research gaps in terms of preparedness, response and recovery at 11 effusive centers, including Piton de la Fournaise.

Raman spectra of Martian glass analogues: A tool to approximate their chemical composition.

Raman spectrometers will form a key component of the analytical suite of future planetary rovers intended to investigate geological processes on Mars. In order to expand the applicability of these spectrometers and use them as analytical tools for the investigation of silicate glasses, a database correlating Raman spectra to glass composition is crucial. Here we investigate the effect of the chemical composition of reduced silicate glasses on their Raman spectra.

Viscosity measurements of crystallizing andesite from Tungurahua volcano (Ecuador).

Viscosity has been determined during isothermal crystallization of an andesite from Tungurahua volcano (Ecuador). Viscosity was continuously recorded using the concentric cylinder method and employing a Pt-sheathed alumina spindle at 1 bar and from 1400°C to subliquidus temperatures to track rheological changes during crystallization. The disposable spindle was not extracted from the sample but rather left in the sample during quenching thus preserving an undisturbed textural configuration of the crystals.

Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.

A novel family of potent dual inhibitors of CK2 and the Pim kinases was discovered by modifying the scaffolds of tricyclic Pim inhibitors. Several analogs were active at single digit nanomolar IC(50) values against CK2 and the Pim isoforms Pim-1 and Pim-2. The molecules displayed antiproliferative activity in various cell phenotypes in the low micromolar and submicromolar range, providing an excellent starting point for further drug discovery optimization.

7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.

A novel class of pan-Pim kinase inhibitors was designed by modifying the CK2 inhibitor CX-4945. Introduction of a triazole or secondary amide functionality on the C-7 position and 2'-halogenoanilines on C-5 resulted in potent inhibitors of the Pim-1 and Pim-2 isoforms, with many analogs active at single digit nanomolar concentrations. The molecules inhibited the phosphorylation at Serine 112 of the apoptosis effector BAD, and had potent antiproliferative effects on the AML cell line MV-4-11 (IC(50) <30 nM).