The impact of surgical margins in managing regional metastases in cutaneous squamous cell carcinoma of the head and neck.

Background: Regional metastasis occurs in 5% of cutaneous squamous cell carcinoma (cSCC). The aim of this study is to assess the impact of margin status of regional metastases on survival.

Methods: A retrospective review of 401 patients with nodal metastases from cSCC.

A review of submandibular gland extirpation in an Australian quaternary referral centre: aetiologies and trends over 35 years.

Background: Submandibular gland pathology is common but rarely reported. This study was performed to evaluate demographic, pathological, and survival outcomes associated with submandibular gland extirpation.

Methods: Retrospective analysis of patients treated in a single quaternary-care institution between 1989 and 2022 was performed.

The effects of age and physical activity status on muscle synergies when walking down slopes.

Purpose: The aim of the current study was to determine whether gait control (muscle synergies) or gait stability (margin of stability (MoS)) were different between younger and older adults when walking on level or downhill slopes. Further, it sought to determine associations between either age or physical activity with muscle synergy widths.

Methods: Ten healthy younger (28.

Allele-specific silencing of a dominant mutation in familial amyotrophic lateral sclerosis type 4.

Amyotrophic lateral sclerosis 4 (ALS4) is an autosomal dominant motor neuron disease that is molecularly characterized by reduced R-loop levels and caused by pathogenic variants in (). encodes an RNA/DNA helicase that resolves three-stranded nucleic acid structures called R-loops. Currently, there are no disease-modifying therapies available for ALS4.

Inhibitory Components in Muscle Synergies Factorized by The Rectified Latent Variable Model from Electromyographic Data.

Non-negative matrix factorization (NMF), widely used in motor neuroscience for identifying muscle synergies from electromyographical signals (EMGs), extracts non-negative synergies and is yet unable to identify potential negative components (NegCps) in synergies underpinned by inhibitory spinal interneurons. To overcome this constraint, we propose to utilize rectified latent variable model (RLVM) to extract muscle synergies. RLVM uses an autoencoder neural network, and the weight matrix of its neural network could be negative, while latent variables must remain non-negative.

Ultrasound-Guided High-Intensity Focused Ultrasound of Uterine Fibroids and Adenomyosis: An 11-Year Experience from a Single Center in Hong Kong.

This study evaluated the efficacy and safety of ultrasound-guided high-intensity focused ultrasound (HIFU) in treating symptomatic uterine fibroids and adenomyosis. HIFU treatments performed in premenopausal women with symptomatic uterine fibroids and adenomyosis were analyzed retrospectively. Lesion volume reduction, change in symptoms of menstrual pain, and quality of life were examined.

Re-engineer apparel manufacturing processes with 3D weaving technology for efficient single-step garment production.

Traditional apparel assembly technology-cut and sewn process-requires labor-intensive pre- and post-production. While conventional weaving technology has made efforts to streamline the garment-making process, additional assembly processes are still required-sewing or joining after removing the woven samples from the loom. This challenge in the garment-making process discloses the need for a novel type of advanced textile technology and manufacturing techniques incorporating shaping and assembly capabilities.

Single-cell transcriptomics reveal differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells.

Cytotrophoblast (CTB) of the early gestation human placenta are bipotent progenitor epithelial cells, which can differentiate into invasive extravillous trophoblast (EVT) and multinucleated syncytiotrophoblast (STB). Trophoblast stem cells (TSC), derived from early first trimester placentae, have also been shown to be bipotential. In this study, we set out to probe the transcriptional diversity of first trimester CTB and compare TSC to various subgroups of CTB.

Practical Considerations of Workplace Wellbeing Management under Post-Pandemic Work-from-Home Conditions.

As a natural experiment or "stress test" on the rapidly shifting work environment from office to home during and after the COVID-19 pandemic, staff wellbeing has been considered as the most critical issue in organizational change management. Following an overview of the relevant literature and recent official statistics, this essay aims to (i) address the major considerations and challenges in light of the transformation and re-design of the mode of work in the new normal and (ii) inform practical decisions for overall staff wellbeing under post-pandemic work-from-home (WFH) conditions with recommendations. For the sake of both staff healthiness and safety, as well as organizational competitiveness, senior management should take reasonable steps to enhance occupational safety in their WFH policy in line with practical recommendations on five areas, namely, (i) ergonomics, (ii) stress and anxiety management, (iii) workplace boundaries, (iv) work-family conflicts, and (v) other factors regarding a negative work atmosphere (e.

Enabling interdisciplinary research capacity for sustainable development: self-evaluation of the Blue Communities project in the UK and Southeast Asia.

Global challenges such as climate change, food security and human health and well-being disproportionately impact people from low-income countries. These challenges are complex and require an international and transdisciplinary approach to research, with research skills and expertise from different disciplines, sectors and regions. In addressing this, a key goal of the research project, Blue Communities, was to create and expand mutual interdisciplinary capacity of both United Kingdom and Southeast Asian Partners.

Concerto of movement: how expertise shapes the synergistic control of upper limb muscles in complex motor tasks with varying tempo and dynamics.

. This research aims to reveal how the synergistic control of upper limb muscles adapts to varying requirements in complex motor tasks and how expertise shapes the motor modules..

Factor analysis of the Chinese version of the Autism Spectrum Quotient 10 and its association with schizotypal traits in adolescents and young adults in Hong Kong.

Background: There is evidence suggesting that autistic traits are associated with schizotypal traits. This study examined the factor structure of the Autism Spectrum Quotient 10 (AQ-10) and its associations with schizotypal traits (measured by the Schizotypal Personality Questionnaire-Brief [SPQ-B]) in a cohort of Chinese adolescents and young adults.

Methods: Invitation letters, stratified by locations and housing types, were randomly sent to individuals aged 15 to 24 years for participation.

Factors Associated with Alternate Level of Care Status Designation: a Case-Control Study and Model to Optimize Care Trajectories.

Background: As health-care demand is growing, our health-care system will require the optimization of the care trajectories. Patients with an alternate level of care (ALC) status could be a target for flow optimization. We aimed to characterize ALC patients and risk factors for ALC status, and to propose an integrated model to analyze the trajectory of ALC patients and discuss solutions to reduce their burden.

Task-based EEG and fMRI paradigms in a multimodal clinical diagnostic framework for disorders of consciousness.

Disorders of consciousness (DoC) are generally diagnosed by clinical assessment, which is a predominantly motor-driven process and accounts for up to 40 % of non-communication being misdiagnosed as unresponsive wakefulness syndrome (UWS) (previously known as prolonged/persistent vegetative state). Given the consequences of misdiagnosis, a more reliable and objective multimodal protocol to diagnosing DoC is needed, but has not been produced due to concerns regarding their interpretation and reliability. Of the techniques commonly used to detect consciousness in DoC, task-based paradigms (active paradigms) produce the most unequivocal result when findings are positive.