Publications by authors named "Chetty S Chellu"
J Biochem Mol Toxicol
November 2019
Article Synopsis
- Environmental exposure to lead (Pb) is linked to the development of Alzheimer's disease, primarily through the formation of β-amyloid peptides (APs), which are major risk factors.
- The study investigates the protective effects of epigallocatechin gallate (EGCG), a compound found in green tea, against the toxic effects of Pb and β-APs on human neuronal cells (SH-SY5Y).
- Results show that EGCG reduces oxidative stress and apoptosis caused by Pb and β-APs, leading to improved cell survival by enhancing certain protein expressions and inhibiting harmful processes.
