Fine-needle aspiration biopsy diagnosis of follicular variant of papillary thyroid cancer: therapeutic implications.

Objective: Frozen-section analysis of follicular lesions is often inconclusive because capsular or vascular invasions are the hallmarks of malignancy with this technique and may not be seen in the particular field studied. Using preoperative fine-needle aspiration biopsy specimens, we attempted to identify malignant follicular lesions and compare these results against frozen-section analysis.

Methods: A retrospective study of 1000 consecutive thyroid fine-needle aspiration biopsy specimens was performed.

Cool laser optics treatment of large telangiectasia of the lower extremities.

Background: Lower extremity telangiectases have been traditionally treated using sclerotherapy. However, because of significant side effects from sclerotherapy, laser treatments have been investigated. Results from laser treatments have been generally unsatisfactory.

Value of fine needle aspiration biopsy of salivary gland masses in clinical decision-making.

The accuracy of fine needle aspiration biopsy (FNAB) in the diagnosis of salivary tumors has been well established. This study was undertaken to determine the impact of FNAB on patient management. One hundred one patients underwent FNAB of major salivary gland masses.

Nonaspiration fine-needle cytology of the liver: a new technique for obtaining diagnostic samples.

We studied a new method of obtaining diagnostic cytology samples from the liver that differs from fine-needle aspiration cytology in that no suction is used to obtain the sample. This method is simpler to perform than traditional aspiration biopsy and yields concentrated cell smears that are easier to interpret. The sample enters the needle because of capillary action, a physical property of fluid that causes it to flow into the lumen of a narrow channel.

Vitrectomy retinotomy aspiration biopsy of choroidal tumors.

We used an investigational technique for the biopsy of intraocular tumors to aid in the diagnosis of three choroidal tumors. A three-port trans-pars plana vitrectomy was performed in conjunction with retinotomy, tumor biopsy, endophotocoagulation, and air-fluid exchange. Vitrectomy was used to decrease the amount of traction secondary to retained vitreous after intraocular surgery.

Primary renal angiosarcoma mimicking a renal cell carcinoma.

Primary renal angiosarcoma is a very rare malignant tumor that closely mimics the more common renal cell adenocarcinoma (hypernephroma) in radiologic appearance. Both tumors are hypervascular masses and the diagnosis must be confirmed histologically. However, in the presence of a tumor with a capsular blood supply, and in the absence of venous invasion, the diagnosis of renal angiosarcoma may be suggested, especially in a patient with a new onset of consumption coagulopathy.

The role of immunoperoxidase staining in diagnostic cytology.

A survey was made of the immune staining characteristics of 60 malignant neoplasms. Cytologically positive smears from each case were tested against a panel of six antibodies (alpha-antichymotrypsin, carcinoembryonic antigen, cytokeratin, desmin, vimentin and S-100 protein). The smears were decolorized and stained with polyclonal sera using the standard avidin-biotin immunoperoxidase procedure.

ECG abnormalities in polymyositis.

Electrocardiographic abnormalities were found in 25 (32.5%) of 77 patients with polymyositis. Left anterior hemiblock (13.

Serum immunoglobulin elevations in the acquired immunodeficiency syndrome (AIDS): IgG, IgA, IgM, and IgD.

The exact nature of the immune defect in the acquired immune deficiency syndrome (AIDS) is not known. Most studies have focused on abnormal T-cell functions which occur in AIDS. Although polyclonal elevation of serum immunoglobulins is also consistently reported in AIDS, there have been no statistical studies measuring the isotypes (classes) comprising this hypergammaglobulinemia.

A method for dissection of discrete regions of rat brain following microwave irradiation.

A simple microdissection technique for obtaining discrete areas from rat brains exposed to microwave irradiation is described and illustrated. Using the atlas of Pellegrino et al. [10] as a guide, stereotaxically defined areas were removed from coronal sections prepared with sectioning stages constructed from microscope slides.

Reversible acquisition of a host cell surface membrane antigen by Trypanosoma cruzi.

The ability of Trypanosoma cruzi, the etiological agent of Chagas' disease to acquire host cell surface antigen was tested. Parasites emerging after intracellular replication in WOS sarcoma monolayers expressed a sarcoma-associated surface antigen. This antigen was deleted from these parasites after replication in the MNS control monolayer, which does not express WOS sarcoma-associated surface antigen, or by replication in cell-free medium.