Publications by authors named "Cheryl Nevins"
Article Synopsis
- Serial passage of arboviruses in lab conditions allows for genetic changes that can affect their virulence, overcoming the limitations of needing to replicate in both vertebrate and invertebrate hosts.
- Different viruses respond differently to this process; Venezuelan equine encephalitis virus showed 11 genetic changes but no notable increase in virulence for mice.
- In contrast, Japanese encephalitis virus experienced up to 22 genetic changes and improved survival rates in mice, with most changes occurring within just 5 passages.
