Induction of the LH Surge in Premenarchal Girls Confirms Early Maturation of the Hypothalamic-Pituitary-Ovarian Axis.

Purpose: To determine whether premenarchal girls exhibit positive estradiol feedback similar to regularly cycling adult women when given exogenous estradiol.

Methods: This was a prospective clinical cohort study at 2 institutions. Nine girls and 6 women received a 7-day course of transdermal estradiol designed to produce physiologic, mid-cycle circulating estradiol levels.

Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women.

Objective: To better understand the site and mode of action of aromatase inhibitors.

Design: Prospective study.

Setting: Academic research environment.

Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery.

Background: Male infertility affects approximately 6% of reproductive-aged men. It has been suggested that overweight men or men with obese body mass index (BMI) experience prolonged time to pregnancy, though the influence of male BMI on fertility remains understudied.

Aims: We hypothesized that BMI is inversely correlated with fertility, manifested by reduced sperm concentration, motility, and morphology.

Replete vitamin D stores predict reproductive success following in vitro fertilization.

Objective: To determine whether 25OH-D levels in the follicular fluid (FF) of infertile women undergoing IVF demonstrate a relationship with IVF cycle parameters and outcome, hypothesizing that levels of 25OH-D in body fluids are reflective of vitamin repletion status.

Design: Prospective cohort study.

Setting: Academic tertiary care center.

Partial recovery of luteal function after bariatric surgery in obese women.

Objective: To determine whether obesity-related reproductive endocrine abnormalities in ovulatory women are reversible with weight loss.

Design: Observational cohort study.

Setting: Healthy volunteers in an academic research environment.