Publications by authors named "Cheryl Clark-Dixon"
Hum Mol Genet
December 2008
Article Synopsis
- The study investigates how the protein alpha-synuclein, linked to Parkinson's disease, leads to cell damage and identifies genes that protect against its harmful effects.
- A genetic screen reveals 40 genes involved in cell protection from alpha-syn toxicity, with five genes (ENT3, IDP3, JEM1, ARG2, HSP82) showing significant protective abilities against reactive oxygen species.
- Among these, ENT3 stands out for its role in transporting alpha-syn to the vacuole for degradation, while also indicating that alpha-syn may cause toxicity through a different mechanism than inherited mutant forms of the protein.
Article Synopsis
- Researchers identified the YGR198w gene (YPP1) in yeast, which helps reduce the harmful effects of a Parkinson's disease-related alpha-synuclein mutant (A30P).
- YPP1 specifically targets the A30P variant, promoting its transport into vesicles that eventually merge with the vacuole for degradation, while it does not affect the wild-type or another variant (A53T).
- The study further reveals that YPP1 interacts with various genes involved in cellular processes like endocytosis and vesicle trafficking, establishing its crucial role in managing the harmful A30P protein.
