Publications by authors named "Cheryl C Y Loh"
The mechanism of action of artemisinin and its derivatives, the most potent of the anti-malarial drugs, is not completely understood. Here we present an unbiased chemical proteomics analysis to directly explore this mechanism in Plasmodium falciparum. We use an alkyne-tagged artemisinin analogue coupled with biotin to identify 124 artemisinin covalent binding protein targets, many of which are involved in the essential biological processes of the parasite.
View Article and Find Full Text PDFArticle Synopsis
- Chloroquine was an effective treatment for the malaria-causing parasite Plasmodium falciparum, but resistance has developed, prompting research on ways to overcome this resistance.
- A new fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, has been introduced as a safer alternative to monitor chloroquine accumulation in the parasite's digestive vacuole, showing stronger effects on chloroquine-sensitive strains than resistant ones.
- Studies on parasite strains indicated that LynxTag-CQGREEN's uptake was affected by the type of PfCRT protein and was influenced by known chemosensitizers, with correlations found between drug uptake and genetic mutations related to drug resistance.