Publications by authors named "Cheryl Allyne Whistler"
Front Pharmacol
September 2024
Article Synopsis
- Opioid drugs activate the µ-opioid receptor, mimicking natural pain-relieving peptides, but their use is limited due to side effects and the risk of opioid use disorder.
- The study examined how different levels of arrestin-3 recruitment to the µ-opioid receptor in mice affected their drug-seeking behavior, revealing that mice without arrestin-3 showed more compulsive tendencies.
- The findings suggest that opioids activating both G proteins and arrestin-3 could lead to decreased risk of abuse, indicating a potential pathway for improving pain management without increasing addiction risk.
