Publications by authors named "Cheryl A Sherman"
Article Synopsis
- - Loss-of-function studies reveal that T cell factor-1 (TCF1) is crucial for T cell development in the thymus, and its expression is regulated by E box DNA binding proteins independently of Notch signaling.
- - Systematic analysis of five E protein binding elements (EPE1-5) shows that EPE3 is vital for αβ T cell development, while EPE1, 3, and 5 are important for γδ T cell maturation and fate decisions.
- - The balanced expression of TCF1, influenced by specific EPEs, is essential for generating the appropriate number of T cells in the thymus.
The nuclear factor kappa B (NF-κB) family of transcription factors orchestrates signal-induced gene expression in diverse cell types. Cellular responses to NF-κB activation are regulated at the level of cell and signal specificity, as well as differential use of family members (subunit specificity). Here we used time-dependent multi-omics to investigate the selective functions of Rel and RelA, two closely related NF-κB proteins, in primary B lymphocytes activated via the B cell receptor.
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