ROS-responsive nucleobase conjugated chitosan: Synthesis and evaluations for biomedical applications.

Herein, chitosan has been functionalized with four nucleobases to investigate its mucoadhesive properties in the hydrogel form. These nucleobase-modified polymers were characterized by NMR, FT-IR, EDAX, TGA and evaluated for its ROS responsive degradation, cytocompatibility, mucoadhesion, hemocompatibility, anti-bacterial, anti-fungal and biofilm inhibitory properties. All the conjugated polymers have shown superior mucoadhesion along with the cyto- and hemo- compatibility as compared to chitosan.