keratitis: confirmation of the UK outbreak and a prospective case-control study identifying contributing risk factors.

Background/aims: keratitis (AK) is a chronic debilitating corneal infection principally affecting contact lens (CL) users. Studies were designed to test claims that the UK incidence may have increased in 2012-2014 and to evaluate potential causes.

Methods: Annualised incidence data were collected from January 1984 to December 2016.

Association of single nucleotide polymorphisms of interleukins-1β, -6, and -12B with contact lens keratitis susceptibility and severity.

Purpose: To investigate whether single nucleotide polymorphisms (SNPs) in interleukin (IL)-1β, IL-6, and IL-12β are associated with the susceptibility and severity of contact lens-related keratitis.

Design: Retrospective, case control study.

Participants: One hundred twelve cases of keratitis and 225 controls were recruited from studies conducted at Moorfields Eye Hospital and in Australia during 2003 through 2005.

Risk factors for nonulcerative contact lens complications in an ophthalmic accident and emergency department: a case-control study.

Purpose: To assess the relative risks of acute, nonulcerative complications with recently introduced contact lens (CL) wear modalities (compared with the previously most common soft lens wear schedule), and to identify any other associated factors.

Design: A 2-year prospective case-control study commencing in December 2003.

Participants: Cases were 877 CL wearers attending Moorfields Eye Hospital with CL-related disorders other than microbial keratitis.