The Possible Immunological Mechanisms of Pathology in Mice with Congenitally Acquired Influenza Infection.

The fact that congenitally acquired viral infection often strongly influences specific and non-specific immunoreactivity is well documented. Viral infection of pregnant female may lead to serious of pathological consequences for the offspring, namely, to mortality, developmental disorders and in less severe cases to body growth retardation, wasting syndrome and immunodeficiency. In this connection, we have studied congenitally acquired influenza infection in CII mice.

The Attenuation of Effectors and Induction of Suppressors of Delayed Type Hypersensitivity Reaction under the Treatment with Psoralen Photooxidation Products.

Psoralens, together with ultraviolet light A (PUVA), are used for the treatment of the series of T cell mediated diseases. The role of photooxidative reactions in psoralen phototherapy is not entirely clear. Using model of delayed type hypersensitivity (DTH) reaction to sheep red blood cells and evaluating the antibody production in mice, we investigated the influence of produced in vitro psoralen photooxidation products (POP) on the functions of T and B effectors.

Peculiarities of virus-specific immune response in mice with congenitally acquired influenza infection.

In this paper we show that progeny of C57BL/6 mice infected during pregnancy with influenza virus display a profound specific areactivity in situ according to their decreased capacity to give plaque-forming cell and delayed-type hypersensitivity responses to influenza virus. In spite of this specific areactivity in situ, spleen cells of mice with congenitally acquired influenza infection can easily transfer virus-specific delayed-type hypersensitivity and plaque-forming cell responses to syngeneic recipients. These results suggest that specific areactivity of mice with congenitally acquired influenza infection observed in situ is not connected with deletion of virus-specific immunocompetent cells after vertical virus transmission.

Blocking activity of the serum from semiallogeneic chimaeras produced by means of cyclophosphamide.

Blocking activity of the serum from semiallogeneic chimaeras produced by the i.p. injection of cyclophosphamide, followed by the i.

Tolerance to allogeneic and to xenogeneic heart grafts provided by thymectomy of adult mice combined with donor cell and cyclophosphamide inoculation.

A new method of induction of tolerance to allogeneic and to xenogeneic cells is presented. It includes thymectomy of adult mice followed 1 month later by the injection of 1 X 10(8) spleen cells i.v.

Marek's disease virus (Kekava strain) replication in chickens, chick embryos and cell cultures.

In the course of 12 passages of Marek's disease virus (MDV) strain Kekava (MDV-Kekava) in chickens, the morbidity varied greatly (from 23 to 50 percent). MDV-Kekava produced plaques in cultures of chick embryo kidney and adult chicken kidney cells and chick embryo fibroblasts (CEF). The virus adaptation to the cultures was very slow.