Climate Influence on Blood Pressure Rhythms and Left Ventricular Parameters in Hypertensive Patients: Comparative Study.

Background: Hypertension is a prevalent condition that significantly impacts cardiovascular health. The rhythmicity of arterial blood pressure (BP) can vary based on climatic conditions, potentially influencing the severity and outcomes of hypertensive complications. The study aims to assess the characteristics of arterial blood pressure rhythmicity in hypertensive patients and their influence on the structural parameters of the left ventricle of the heart in both temperate and subarctic regions of Russia.

Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia.

Background: To determine the effect of genetic polymorphism of drug transporters on the efficacy of treatment with Rosuvastatin, Atorvastatin and Simvastatin in patients with hyperlipidemia.

Methods: The study consists of 180 patients, aged 40-75 years, with hyperlipidemia. All patients were divided into two equal groups: patients with different SLCO1B1 (521CC, 521CT and 521TT) and MDR1 (3435CC, 3435TC and 3435TT) genotypes.