[A case of thoracic actinomycosis].

A case of thoracic actinomycosis manifest as round shadow in the lung is described. Diagnosis was based on the presence of actinomycetes in a transthoracic lung biopsy sample. Treatment for 3 months resulted in recovery.

[The clinical and endoscopic state of the esophagus in patients with asthma concurrent with chronic opisthorchiasis].

The frequency and pattern of manifestations of gastroesogageal reflux disease were studied in asthma concurrent with chronic opisthorchiasis. One hundred and fifty patients (52 males and 98 females) aged 14 to 60 years (mean age 43.18 +/- 10.

[Trophologic insufficiency and absorptive function of small intestine in patients with chronic obstructive pulmonary disease].

The study included 93 patients with grade 1-3 chronic obstructive pulmonary disease (COPD) in the stable clinical phase. Absorptive function of the small intestine was evaluated by biochemical methods and with the use of radionuclides; plasma tumour necrosis factor-alpha (TNF-alpha) levels were measured by an enzyme immune-assay. Trophologic status in 44% of the patients with COPD was unaltered whereas 14% had an excessive body weight.

[Erosive lesions in the gastroduodenal zone of patients with bronchial asthma].

The purpose of the investigation was to study the frequency and clinicomorphological features of erosive lesions (EL) in the gastroduodenal zone (GDZ) of patients with bronchial asthma (BA). One hundred and sixty-three patients suffering from allergic BA of different degrees of severity were examined. The examination included clinical evaluation of the GDZ, esophagogastroduodenoscopy with gastric and duodenal mucosal biopsy, and subsequent analysis of the biopsy samples using histological, histochemical, morphometric methods, and electron microscopy.

[The vasomotion characteristics in isolated segment of the tail artery under conditions of slow constant increase of the perfusion pressure].

In vitro, the Wistar rat tail artery segments were perfused with the Crebs-Henselite solution. Under the conditions of perfusion pressure increasing from 0 to 110 mm Hg with the velocity of 5 mm Hg/min, the "diameter-pressure" curves were obtained. Changes in the vessel diameter during increase of pressure in the vessel were accompanied by vasomotions.

[Responses of isolated arterial segment to a slow changing of perfusion pressure in it].

In in vitro experiments, segments of the Wistar rat tail artery's segments were perfused with the Krebs-Henselite solution. Increase of the perfusion pressure with the velocity of 5 mm Hg/min from 0 to 110 mm Hg with its subsequent drop with the same velocity down to zero showed that, within the limits of the above interval of values of the intravascular pressure, existed a range where two values of the artery diameter corresponded to each established value of the pressure. The data obtained prompt a further deciphering of mechanisms of the mechanogenic regulation of the blood vessels.

[Peculiarities of duodenal ulcer with concomitant bronchial asthma (clinical and pathomorphological aspects)].

Aim: To study incidence of gastroduodenal ulcer (GDU) in bronchial asthma and clinicomorphological features of ulcer disease in BA in long-term use of systemic corticosteroids (SCS) and without SCS.

Material And Methods: The trial covered 297 BA patients. They have undergone clinicoendoscopic examination of the gastroduodenal zone (GDZ) for duodenal ulcer with assessment of clinical gastroenterological symptoms and morphological analysis of biopsies of gastric and duodenal mucosa using histological, histochemical and morphometric methods.

[Clinical and immunologic correlations of gastroduodenal lesions in patients with bronchial asthma].

To study local immunity of the stomach in bronchial asthma (BA) and the role of some immunity factors deficiency in development of gastroduodenal disturbances in BA patients, we have examined 271 male and female patients aged 18 to 60 years with exogenic and mixed BA of different severity. Gastroduodenal erosions were endoscopically diagnosed in 61 (22.5%) patients.

[Impact of long-term systemic glucocorticoid therapy for bronchial asthma on the occurrence and course of peptic ulcer].

The study was undertaken to examine the incidence and specific features of peptic ulcer (PU) of the gastroduodenal area (GDA) in bronchial asthma (BA) and the impact of long-term oral maintenance therapy with systemic glucocorticosteroids (GCS) on the occurrence and course of peptic ulcer. Among the 260 examined patients with BA, GDA PU was revealed in 70(26.9%).

[Endogenous factors in the pathogenesis of vulvar cancer].

In 59 patients with cancer of the vulva, levels of ACTH, FSH, thyrotropin, prolactin, somatotropin, cortisol, triiodothyronine, thyroxin, testosterone, progesterone and estradiol were measured in blood whereas those of 17-HOCS, 17-CS and estrogens--in urine. Hormonal imbalance was established at all levels of the endocrine system, viz. increased concentrations of cortisol and 17-HOCS, decreased ACTH level, shift in androgen/estrogen and androgen/progestin ratios towards testosterone, lowered FSH and somatotropin output and elevated blood-prolactin level.

[Endogenous factors in the development of leukoplakia and kraurosis vulvae].

Levels of tropic hormones of the pituitary, glucocorticoids and male and female sex hormones were assayed in 17 cases of kraurosis and leukoplakia of the vulva prior to treatment. Most patients revealed an abnormally high androgen/estrogen ratio, elevated level of glucocorticoids and low concentrations of thyrotropic hormone, prolactin and T3. The above disturbances are closely related and interdependent.

[The kallikrein-kinin, coagulation and fibrinolytic systems of the blood in patients with chronic glomerulonephritis and the hypertension syndrome].

A study of 47 patients with the hypertensive variant of chronic glomerulonephritis revealed a reduction of the functional activity of the kallikrein-kinin, coagulation and fibrinolytic systems of the blood that may be of importance in the genesis of the hypertensive syndrome in patients with chronic glomerulonephritis. A correlation was established between some indices of these systems and the influence was found of the arterial pressure on individual factors of these systems.

[The effect of the inhalation of a single atrovent dose on pulmonary ventilation function and respiratory mechanics in patients with chronic obstructive bronchitis].

A study was made of the action of inhalation of a single atrovent dose in 20 patients with chronic obstructive bronchitis. All the patients demonstrated a considerable abatement or disappearance of dyspnea, and a reduction of the number of dry rales. The vital capacity of the lungs, the volume of forced expiration, maximal pulmonary ventilation, MOCmax, MOC50, and MOC75 substantially increased.

[Direct effect of hypoxia on the function of skeletal muscle blood vessels in the cat].

In decentralized skeletal muscles of the cat hindlimbs, pO2 of arterial blood dropped from 105 to 87, 68 and 37 mm Hg in artificial respiration with 18% O2 (slight), 14% O2 (moderate) and 8% O2 (grave hypoxia) mixtures, resp. The slight hypoxia practically did not affect vascular resistance and capacity, distensibility of veins, capillary filtration coefficient and mean capillary hydrostatic pressure. Moderate and grave hypoxia reduced perfusion pressure by 3.

[Direct effect of hypoxia on the functions of the small intestinal vessels of the cat].

In anesthetized cats, artificial ventilation with 18, 14 and 8% O2 mixtures decreased the arterial blood pO2 from 104 to 85, 69 and 38 mm Hg, resp. Resistance of the intestine vessels and their capacity decreased in 14 and 8% O2; the capillary filtration coefficient increased at all levels of hypoxia whereas distensibility of veins and mean capillary hydrostatic pressure practically did not alter. A significant diminishing of constrictor responses of the intestine arterial vessels to noradrenaline only occurred in 8% O2.

[Coefficient of capillary filtration and distensibility of small intestine vessels at various levels of blood flow and venous and perfusion pressure].

In the cat decentralized small intestine perfused with a constant blood volume, the capillary filtration coefficient (CFC) increased from 0.02 to 0.22 ml/min/mm Hg/100 g on increase of the venous pressure from 0 to 18 mm Hg.

[Capillary filtration coefficient and the distensibility of the venous vessels of the small intestine in the process of high-altitude adaptation].

In acute experiments on cats, the increase of capillary filtration coefficient and venous distensibility in small intestine was revealed after 3-5, 14-16 and 29-31 days of high altitude adaptation (The Pamirs, 3370 m above sea level), the changes being more obvious (by 78% and 45%, resp.) after 3-5 days in comparison with low altitude control. The effects of noradrenaline on the small intestine precapillary sphincters and venous distensibility were preserved at high altitude, whereas regional blockade of alpha- or beta-adrenoreceptors exerted no effect on the results.

[Adrenoreactivity of the vessels of the small intestine during adaptation to high altitude in the cat].

Responses of the resistance and capacitance vessels of small intestine to adrenergic stimulation and blockade were studied in acute experiments on cats after 3-30 days of high altitude adaptation (the Pamirs, 3370 m). In comparison to control (Dushanbe, 830 m) constrictor responses of the resistance vessels to noradrenaline and adrenaline were significantly increases at high altitude, whereas the dilator responses to beta-stimulator propranolol were obviously reduced. Changes of venous blood outflow from small intestine in response to catecholamines at high altitude exceeded the control values.

[Effect of adrenoreceptor blockade and stimulation on the resistance and capacitance of intestinal vessels].

Resistography and extracorporeal venous flow in cats revealed that i. a. administration of noradrenaline (NA) increased the intestine vascular resistance, adrenaline (A) decreased it and novodrine (N) sharply decreased it in all the experiments.