[Antimicrobial activity of ceftazidime and its pharmacokinetics in patients with renal failure].

High antimicrobial activity of ceftazidime against clinical gram-positive (except Streptococcus viridans and S. faecalis) and gram-negative strains of microorganisms was shown. It was found that the drug dosing regimens required correction in cases with impaired excretion function of the kidneys.

[Ultraviolet irradiation of the blood in the treatment of pyo-inflammatory complications in patients with terminal renal failure].

The authors describe a technique of extracorporeal UV radiation of blood (EUVRB) in flow closed circulation. Its efficacy was assessed in combined treatment of pyo-inflammatory complications of terminal renal failure. Therapeutic effects of EUVRB are due to reduced endogenic intoxication, correction of leukopoiesis and stimulation of immunity.

[Immunologic criteria of severity of suppurative infections in patients on programmed hemodialysis].

Certain parameters of the immune system were studied in patients under programmed hemodialysis with and without pyo-inflammatory complications. It was found that patients without pyo-inflammatory diseases are characterized by the state of immune deficiency while in patients with purulent infection the degree of inhibition of immune response of the organism correlates with spread of the suppurative process.

[Ultrastructural changes in the erythrocytes irradiated with ultraviolet light].

The ultrastructure of erythrocytes of donor blood and blood of patients suffering from kidney insufficiency was studied with the help of scanning and transmission electron microscopes before and after it was treated with ultraviolet light. It was concluded that after being treated with ultraviolet light, the ultrastructure of donor blood erythrocytes undergoes significant positive changes which are being characterized by normalization of the form of cells, decrease of associative ties between them, the cytoplasm content becomes more homogenous. There was a noticeable increase of a number of discocytes and a decreased number of associative ties between the cells after the patients' own blood was treated with ultraviolet light.

[Diagnostic potential of phonoangiography of extracranial arteries].

Phonoangiography (PAG) was applied to study the extracranial parts of cerebral blood vessels in 16 symptom-free healthy individuals and 92 patients with cerebrovascular disorders. The conductance of cardiac tones to the cerebral arteries was assessed in comparison between PAG and phonocardiography. Correlations were found between the arterial wall elasticity, luminal changes and heart sounds conduction.

[The effect of ultraviolet irradiation of patients' blood on the morphofunctional status of erythrocytes].

The morphofunctional status of red blood cells was studied in patients with terminal renal failure associated with pyo-inflammatory complications treated by means of ultraviolet radiation of autologous blood. The authors have established that ultraviolet radiation of autologous blood results in the increase of the discocyte count and red blood cell activation, evidenced by the rise of the young red blood cell count, of the red blood cell population with marked activity of glucose 6-phosphate dehydrogenase, of the content of sulfhydryl groups, and by the increase of erythrocytic adhesion.

[Morphofunctional changes in blood cells irradiated with ultraviolet light].

Red cell and leukocyte morphology and function have been examined in donor blood UV irradiated in a flow closed circulation. The studies have revealed that a single UV irradiation enhances red cell resistance to chemical hemolysis, helps them acquire normal shape; besides, it improves leukocytic functional activity, that manifests by enhanced phosphatase activity and augmentation of the granulocyte phagocytic activity.

[Combined methods of extracorporeal detoxication in the treatment of severe surgical endotoxemia].

A combined method of treatment--flowing ultraviolet irradiation of autoblood with hemosorption or exchange plasmapheresis--was used in 52 patients with pyoseptic diseases. It was shown that inclusion of combined extracorporal detoxication in the complex treatment was followed by a pronounced clinical effect and correction of biochemical and physiological parameters.

[Pharmacokinetics of cefazolin during hemosorption and hemodialysis].

The influence of hemosorption and hemodialysis on the pharmacokinetics of cefazolin was studied in 20 patients with chronic and acute renal insufficiency. The integral mean value of the antibiotic extraction coefficient in hemosorption was approximately 2 times higher than that in hemodialysis. In the first case the value of this parameter systematically lowered with time (the constant of the process rate amounted to 0.

[Application of the technic of laser welding to creation of extra-intracranial microanastomoses].

A method for joining vessels by means of argon laser, i. e. by "laser welding" was developed.

[Pharmacokinetics of ampicillin in patients with chronic renal insufficiency during hemodialysis and hemosorption].

It was shown that when the filtration capacity of the kidneys was lowered even insignificantly (the creatinine clearance 50-80 ml/min), the maximum blood levels of ampicillin increased 2 times and its retention time was prolonged. At the terminal stage of chronic renal insufficiency the half-life of the drug and the area under the pharmacokinetic curve markedly increased and the plasma clearance decreased. Hemodialysis and hemosorption significantly lowered the ampicillin half-life.

[Pharmacokinetics of sisomicin during hemosorption and hemodialysis].

The effect of hemosorption and hemodialysis on the pharmacokinetics of sisomicin was studied in 17 patients with acute and chronic renal insufficiency. The value of the antibiotic extraction coefficient in hemosorption was almost 2 times higher than that in hemodialysis. In patients on hemosorption, extracorporeal elimination of the antibiotic was of the saturation nature.