[Stagewise treatment of tandem lesions of the internal carotid artery in patients with ischaemic stroke].

Aim: The study was aimed at assessing the results of a stagewise approach to surgical treatment of patients with ischaemic stroke and tandem lesions of coronary arteries.

Patients And Methods: We analysed the results of treating a total of 19 patients with ischaemic stroke having endured in 2017-2018 surgical interventions for tandem lesions of the internal carotid artery. All 19 patients with tandem lesions underwent as the first stage of surgical treatment recanalization of the intracranial portion of the internal carotid artery.

A Pharmacokinetic Bioequivalence Study of Fremanezumab Administered Subcutaneously Using an Autoinjector and a Prefilled Syringe.

Fremanezumab (AJOVY; Teva Pharmaceutical Industries Ltd, Netanya, Israel), approved for the preventive treatment of migraine, is available as a subcutaneous injection either once a month or once every 3 months using an autoinjector or a prefilled syringe. The present study evaluated the pharmacokinetic (PK) bioequivalence of a single subcutaneous injection of fremanezumab 225 mg administered using an autoinjector compared to a prefilled syringe in healthy volunteers. Blood samples for PK and antidrug antibodies were collected before and after dosing.

The Effect of Piperine Pro-Nano Lipospheres on Direct Intestinal Phase II Metabolism: The Raloxifene Paradigm of Enhanced Oral Bioavailability.

Phase II biotransformation reactions have been gaining more attention due to their acknowledged significance in drug bioavailability, drug development, and drug-drug interactions. However, the predominant role of phase I metabolism has always overshadowed phase II metabolism, resulting in insufficient data regarding its mechanisms. In this paper, we investigate the effect of an advanced lipid based formulation on the phase II metabolism process of glucuronidation, occuring in the enterocytes monolayer.

PTL401, a New Formulation Based on Pro-Nano Dispersion Technology, Improves Oral Cannabinoids Bioavailability in Healthy Volunteers.

There is a growing clinical interest in developing and commercializing pharmaceutical-grade cannabinoid products, containing primarily tetrahydrocannabinol (THC) and cannabidiol (CBD). The oral bioavailability of THC and CBD is very low due to extensive "first-pass" metabolism. A novel oral THC and CBD formulation, PTL401, utilizing an advanced self-emulsifying oral drug delivery system, was designed to circumvent the "first-pass" effect.

Piperine-pro-nanolipospheres as a novel oral delivery system of cannabinoids: Pharmacokinetic evaluation in healthy volunteers in comparison to buccal spray administration.

Nowadays, therapeutic indications for cannabinoids, specifically Δ-tetrahydrocannabinol (THC) and Cannabidiol (CBD) are widening. However, the oral consumption of the molecules is very limited due to their highly lipophilic nature that leads to poor solubility at the aqueous environment. Additionally, THC and CBD are prone to extensive first pass mechanisms.

The effect of Pro NanoLipospheres (PNL) formulation containing natural absorption enhancers on the oral bioavailability of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a rat model.

The lipophilic phytocannabinoids cannabidiol (CBD) and Δ-tetrahydrocannabinol (THC) show therapeutic efficacy in various medical conditions. Both molecules are poorly water soluble and subjected to extensive first pass metabolism in the gastrointestinal tract, leading to a limited oral bioavailability of approximately 9%. We have developed an advanced lipid based Self-Emulsifying Drug Delivery System termed Advanced Pro-NanoLiposphere (PNL) pre-concentrate.

Self-nano-emulsifying drug delivery systems: an update of the biopharmaceutical aspects.

Introduction: Thirty percent of top marketed drugs in the USA and 70% of all new drug candidates are lipophilic and exhibit poor water solubility. With such physicochemical properties, the oral bioavailability of these compounds lacks dose proportionality, is very limited and extremely erratic. Different lipid-based formulations have been explored in the past few decades to improve the oral delivery of such compounds.

[Long-term results of surgical treatment of the extracranial arteries aneurysm].

Aneurysms of extracranial arteries are sufficiently rare pathology in the extracranial arteries surgery. The authors aimed to research the frequency of occurrence of the extracranial arteries aneurysm, reasons of the onset, the localization, clinical manifestations and surgical treatment strategy. A retrospective study presents 10 cases of the extracranial arteries aneurysm for the last 5 years.

Improved oral bioavailability of BCS class 2 compounds by self nano-emulsifying drug delivery systems (SNEDDS): the underlying mechanisms for amiodarone and talinolol.

Purpose: Superior bioavailability of BCS Class 2 compounds incorporated into SNEDDS was previously reported. This study aims to elucidate the underlying mechanisms accountable for this phenomenon.

Methods: SNEDDS of amiodarone (AM) and talinolol were developed.

Lipospheres and pro-nano lipospheres for delivery of poorly water soluble compounds.

Lipospheres are a drug encapsulation system composed of water dispersible solid microparticles of particle size between 0.01 and 100 μm in diameter with a solid hydrophobic lipid core stabilized by a layer of phospholipid molecules embedded in their surface. The bioactive compound is dissolved or dispersed in the solid lipid matrix of the internal core.

[The altitude chamber flights as a method of the psychophysiologic training of pilots against stress situations].

The study of literature and aviation incidents during the depressurization of the aircraft cabin in the altitude higher than 12 km. Shows that their serious outcomes are often connected with wrong evaluation of the emergency situation by pilots, making incorrect decision and carrying out inadequate actions. In order to improve psychophysiologic training for stratosphere flights and to increase their safety the authors suggest approbated methods of periodic altitude chamber flights of flying personnel to the altitude of 13.

[Trends in providing the medical support for safety of high altitude flights].

The article has analyzed the main development and improvement stages of medical support of high-altitude flight safety. Test results of a full-scale model of the on-board active flight-safety system [symbol: see text]-2 have been given. There have been formulated prospective trends of further studies of the complex system development of crew-life support, widespread use of computer-aided technologies, as well as practical introduction of rehabilitating hypoxy-based trainings in order to increase in the pilot organism functional reserves.

[Predictive information of basic indices of biochemical status of a man in evaluating the tolerance to acute hypoxia].

Under simulation of acute hypoxic hypoxia with participating the volunteers (men) there has been studied the predictor significance of the biochemical indices characterising an intensity of lipoperoxidation process, hormonal status and level of fermentemia. It is indicated that the following indices, namely, LDH, a [symbol: see text]-DPDH, MPD, secondary products of POL, SOD, insulin, cAMP and cAMP/cGMP have the prognostic validity. The revealed combination of the reliable relations was approximated by the equations of one-factor regression.

[Biochemical evaluation of various respiration conditions during simulation of extended flight].

During a simulated long-term mission with participation of male volunteers biochemical effects of various conditions of oxygen supply including breathing the cabin air at 2.4 km, pure oxygen, and intermittent hypoxia/hyperoxia, i.e.

[Pharmacological correction of lipid peroxidation during hypoxia and possibility to enhance human resistance to high altitude by using preparations of the metabolic type of action].

In simulating acute hypoxic hypoxia with the participation of male volunteers, the authors investigated the antihypoxic and antioxidative activity of metabolic drugs (jakton, amtizole succinate, nootropil, probucol, and a mixture which consists of jakton, amtizole succinate, and probucol). The pharmaceuticals were shown to have heterodirectional effects on lipid peroxidative processes. Drugs having a pronounced antioxidative activity (such as probucol and the mixture) promotes oxygen utilization during hypoxia and posthypoxic reoxygenation chiefly by the oxygenase pathway.

[History of solving medical problems of safety provisions of altitude flights].

The paper outlines the basic landmarks of the activity of the workers of the RF State Research Test Institute of Aviation and Space Medicine who have solved the problems of altitude flight safety provision, designed various sets of oxygen and altitude equipment. The main results of the investigations made by the Altitude Department of the Institute are summed up and some promising directions of its workers' activities are shown.

[Maintenance of vitality and performance of pilots by means of oxygenation equipment complex in emergency depressurization of the cabin].

The authors studied efficiency of life supply by means of Oxygenation Equipment Complex (OEC) for pilots subjected to depressurization of the cabin in emergency on altitudes under 20 km. OEC provides breathing under the excessive oxygen pressure and light-weight ammunition. Efficiency of the complex was evaluated through polling the examinees, the time of the discomfort occurrence, changes of the cardiorespiratory and visual parameters, functional tests and quality of the piloting.

[Familiarization drills with barochamber ascents for flight personnel as an element in their psychophysiological training for high-altitude flights].

A new method of altitude chamber climbs of flight personnel (for familiarization and training) has been worked out. The aim of this method is to form among aircrew members the skills to recognize hypoxia in flight and to train them in taking practical measures to remove it. This method appeared to be informative: hypoxia awareness was registered after 3-9 minutes of staying at an altitude of 5000-6000 m in 93% of tested persons.

[The possibility for the pilot to recognize hypoxia in a high-altitude flight].

The article studies the possibility of man to self-diagnose the development of hypoxia and take decisive actions on its elimination with the help of flight living facilities. Four variants of hypoxia were modeled at hyperbaric chamber and flight simulator. The differences between these four variants were the following: strength, increase velocity and duration of hypoxia, the level of "notification" about the oxygen conditions for tested persons.

[Effectiveness of hyperbaric oxygenation as a factor of increasing the resistance of the human body to space flight conditions].

In four experimental runs (30 test subjects in 407 tests), the beneficial effect of hyperbaric oxygenation (HBO) on flight tolerance was demonstrated. HBO sessions (7-8 sessions of an hour in duration during 10-12 days at pO2 = 2 atm) helped subjects with poor altitude tolerance to increase the altitude ceiling by 1 km and reserve time at altitudes of 6-7 km by 3-4 min, the effect being persistent for 2-3 months. Statokinetic tolerance of subjects with medium motion sickness susceptibility grew by 2-2.

[Effectiveness of oxygen equipment as a means of the life support system during space flights].

This paper presents pooled data about the factors determining health status and work capacity of aircrew using positive pressure breathing systems at altitudes over 12,000 m. It is indicated that the system compensating positive pressure is primarily responsible for the protective and ergonomic characteristics of altitude equipment.