Publications by authors named "Chern-Han Ou"
Article Synopsis
- Ganoderma lucidum, a traditional herbal medicine in Asia, has polysaccharide extracts, particularly F3, that demonstrate immuno-modulating and anti-tumor properties by activating key cytokines.
- In an investigation using human leukemia THP-1 cells, the effects of F3 were studied through advanced methods like DNA microarray analysis and quantitative PCR, revealing significant disturbances in cellular pathways.
- The research concluded that F3 may trigger apoptosis in THP-1 cells through death receptor pathways, highlighting a complex regulatory network involving gene interactions and protein recruitment linked to cell signaling and death.
Synthetic peptides with the arginine-glycine-aspartate (RGD) motif have been used widely as inhibitors of integrin-ligand interactions to study cell growth, adhesion, migration and differentiation. We designed cyclic-RGD peptide (Tpa-RGDWPC-, cRGD) which could cause cell death in MCF-7 cell line. In order to understand the mechanism involved in cRGD-induced apoptosis, we used microarray, real-time quantitative PCR (Q-PCR) and bioinformatics to study the effects of cRGD on breast cancer cell line MCF-7.
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