PECULIARITIES OF MORTALITY DUE TO NEOPLASMS IN UKRAINE: WHAT ARE THE THREATS OF COVID- 19 PANDEMIC?

The purpose of the study is to identify the features of the mortality regime from neoplasms in Ukraine, to make comparisons with selected countries in the WHO European Region, to identify challenges to public health and cancer services in connection with the COVID-19 pandemic and to hypothesize possible changes in mortality.The materials for the analysis were the data of official national statistics on mortality (State Statistics Service of Ukraine), data of the National Cancer Registry of Ukraine, and the European Health Information Gateway in the position "Neoplasms" ICD-10 codes: C00-D48. The method of standardization and comparative analysis was used.

On the Validity of Forced Choice Scores Derived From the Thurstonian Item Response Theory Model.

Forced choice (FC) measures may be a desirable alternative to single stimulus (SS) Likert items, which are easier to fake and can have associated response biases. However, classical methods of scoring FC measures lead to ipsative data, which have a number of psychometric problems. A Thurstonian item response theory (TIRT) model has been introduced as a way to overcome these issues, but few empirical validity studies have been conducted to ensure its effectiveness.

[SERRATED COLORECTAL ADENOCARCINOMA].

The Aim: To present a clinical case of serrated colon adenocarcinoma. To demonstrate morphological and genetic features of these tumors and to determine their clinical management.

Key Points: Described case shows diagnostics of serrated colon adenocarcinoma.

[Study of protective activivty of "Staphylovac-2" vaccine].

Aim: Study the protective properties of "Staphylovac-2" vaccinie.

Materials And Methods: Samples of the vaccine manufactured by SPA "Microgen" based on the developed technology were studied in balb/c mice during 3- and 6-fold immunization schemes. Protective activity of the preparation was determined in experiments with active and passive protection during intraperitoneal infection, seeding of the causative agent from spleen and kidneys during intravenous infection, of animals.

[Influence of Staphylococcus vaccine on functional activity of antigen-presenting cells].

Aim: Study the influence of staphylococcus vaccine on functional activity of antigen-presenting cells.

Materials And Methods: Mice intraperitoneally received 500 μg of "Staphylovac" vaccine. Phagocytic activity of peritoneal macrophages against Staphylococcus aureus 1991 was determined in animals at various time intervals.

[Immunogenic properties of experimental production series of Staphylovac-2 vaccine].

Aim: Study experimental production series of Staphylovac-2 by accumulation of specific IgG and safety.

Materials And Methods: Experimental production samples of staphylococci vaccines were studied by the accumulation of specific IgG in sera of immunized BALB/c line mice in EIA. Safety was evaluated in tests of acute and chronic toxicity including pathomorphologic and histologic, hematologic and biochemical studies, studies of the effect on central nervous system.

[Use of multislice spiral computed tomography to diagnose and control pulmonary complications in intensive care unit patients after neurosurgical interventions].

Objective: To perform a multifactorial analysis of the association of the development of complications in neurologic intensive care unit patients in the early (on days 1-3) postoperative period and with surgical conditions, mechanical ventilation parameters, and risk factors.

Subject And Methods: The results of multislice spiral computed tomography (MSCT) of the chest and brain were analyzed in 80 patients (34 men and 46 women; mean age, 52 +/- 13 years).

Results: In the study patient group, the incidence of pulmonary edema and pneumonia was not found to depend on the type of neurosurgical intervention and that of an inhaled anesthetic.

[Analysis of extracellular proteome of Staphylococcus aureus 6 at the end of exponential growth phase].

Aim: Determine protein specter that Staphylococcus aureus synthesizes and secretes at early growth phase--the exponential phase.

Materials And Methods: Proteins secreted by S. aureus strain 6 into cultivation medium at the end of exponential growth phase (4.

[The morbidity dynamics of alimentary-associated diseases in children and adolescents in Northern administrative district of Moscow over a period of 2006-2010].

Through socio-hygienic monitoring of the Northern administrative district of Moscow in 2006-2010 the study of nutritional status and morbidity rates for alimentary-associated diseases of the digestive tract, the endocrine system, cardiovascular diseases and obesity - was conducted in children (5-11 years old), adolescents (12-16 years old) and adult population. Over the last 5 years negative dynamics in morbidity rates for the illnesses related to malnutrition and nutritional status disturbances was shown in children and adolescents. Thus it was noted a considerable increase of alimentary-associated diseases among children (2,3 times more) and adolescents (2,1 times more).

[Comprehensive hygienic evaluation of the environment and health status of children and adolescents in the North administrative district of Moscow].

The high environmental levels of foreign chemical substances and the inadequate intake of both essential nutrients, such as proteins, fats, carbohydrates, and micronutrients, such as minerals, vitamins, and trace elements, in half of the examined children and adolescents promoted a rise in the incidence of chronic noncommunicable diseases in 2005-2009 particularly in the districts of Dmitrovskv, Khovrino where the morbidity rates were 1.5-2 times higher than those in the whole area.

[The morbidity dynamics of acute intestinal infections in the Northern Administrative District of Moscow].

Acute intestinal infections morbidity of the Northern Administrative District of Moscow population was analyzed as a part of the socio-hygienic monitoring. Long-term dynamics and growth, both among total and child population (respectively on 29.5 and 72.

[Characteristics of antigenic complexes of Staphylococcus aureus vaccine strains obtained in different cultivation conditions].

Aim: Assessment of characteristics of antigenic complexes of Staphylococcus aureus vaccine strains in different cultivation conditions.

Materials And Methods: S. aureus vaccine strains (No.

[Microbial contamination of Moscow dwelling rooms].

The rise of allergic diseases warrants an investigation of various environmental factors that are able to influence man negatively. By interacting with the human organism, bacteria and their decomposition products are well-known to stimulate different immunological reactions. The 24-month study has indicated that the total bacterial contamination of dust and the typical diversity of microbes depend on the season.

[Growth medium for Neisseria meningitidis isolation].

Growth medium for isolation of N. meningitidis, which do not require addition of serum and based on previously developed medium for cultivation of bacteria from Haemophilus genus (without growth factors V and X) was constructed. Selective properties of the medium in relation to meningococci were determined by addition of vancomycin and colistin--antibacterial supplement inhibiting growth of nonpathogenic Neisseria and outside microflora.

[Protective effect of the aerosol immunization of mice with the polycomponent vaccine Immunovac VP-4 after the challenge of the animals with Klebsiella pneumoniae virulent strain].

Used four schemes of the administration of the preparation with different time of the exposition of the animals in an aerosol chamber were tested with their subsequent intraperitoneal challenge with K. pneumoniae virulent strain K16. Irrespective of the number of immunization courses, the administration of the preparation made at intervals of 1 day, or daily, did not ensure any protective effect, but only led to an insignificant increase in their survival time in comparison with nonimmunized animals.

Characteristics of human neural stem cells in vitro and after transplantation into rat brain.

We studied the effect of culturing conditions on the fate of human neural stem cells after transplantation into rat brain. Human neural stem cells cultured in the presence of mitogens without LIF migrated along the ependyma and cerebral vessels of recipients, but to a great extent degenerated by the 20th day after transplantation. Neural stem cells cultured with LIF migrated, apart from the above mentioned pathways, in the cortex and hippocampus, well survived; proliferating cells were retained 30 days after transplantation.

[Spread of salmonellosis in Moscow and the ways of its prophylaxis].

The article deals with the results of the epidemiological analysis of the spread of salmonellosis in Moscow. During the last 15 years the proportion of Salmonella enteritidis was about 80% and more. After salmonellosis morbidity decreased to 19.

[Transplantation of stem/progenitor cells of human brain into the brain of adult rats].

We studied the development of stem/progenitor cells of the human brain transplanted in the adult rat brain after reproduction in an in vitro tissue culture. It was preliminarily shown by the immunological methods that the stem cells grown in a medium with growth factors formed neurospheres, which were heterogenous and contained both stem and progenitor cells of the human brain. The cells were implanted in the hippocampus, striatum, or lateral ventricle of the rat brain as a suspension or aggregates (neurospheres) and their behavior and differentiation were studies within 10, 20, and 30 days using the morphological and immunochemical methods.