Publications by authors named "Cherish Lorica"
Chromosomally-Encoded Type III Secretion Effector Proteins Promote Infection in Cells and in Mice.
Front Cell Infect Microbiol
November 2019
, the causative agent of plague, possesses a number of virulence mechanisms that allows it to survive and proliferate during its interaction with the host. To discover additional infection-specific factors, a transposon site hybridization (TraSH)-based genome-wide screen was employed to identify genomic regions required for its survival during cellular infection. In addition to several well-characterized infection-specific genes, this screen identified three chromosomal genes (, and ), located in an apparent operon, that promoted successful infection.
View Article and Find Full Text PDFADV is frequently seen in our pediatric SOT population. It presents in a variety of clinical presentation and can cause severe disease. In this population, there are very few studies to determine the safety of CDV as a potential therapeutic agent.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the plague bacterium Yersinia pestis's anti-host strategies by screening 100,000 mutants and identifying ompA as a critical gene for survival against host immune cells.
- - Researchers found that an engineered strain lacking ompA is still capable of using its type III secretion system (T3SS) but struggles to survive inside macrophages, implying ompA's specific role in intracellular survival.
- - Unlike OmpA in other bacterial species, which helps with attachment and resistance, Y. pestis's OmpA is essential for surviving within host cells and is as important for virulence as the T3SS.