Publications by authors named "Cherif Titah"
Comparison of subconjunctival TRIamcinolone acetonide injection and intravitreal dexamethasone (OZurdex) injection for uveitic and postoperative macular oedema: the TRIOZ study.
Br J Ophthalmol
August 2024
Article Synopsis
- The study aimed to compare the effectiveness of subconjunctival triamcinolone acetonide injections with intravitreal dexamethasone implants in reducing central macular thickness in patients with uveitic and postoperative macular edema.
- An open-label, multicenter trial involved 106 adults who were randomly assigned to receive either treatment; the main measure was the change in central macular thickness after 2 months.
- Results indicated that triamcinolone is likely as effective as dexamethasone, particularly for postoperative edema, with no significant differences in side effects, but conclusive non-inferiority was not established at the 2-month mark.
Article Synopsis
- Paediatric granulomatous uveitis (PGU) is a rare eye condition in kids that can cause serious problems with vision if not diagnosed early.
- The study looked at 50 young patients to understand the causes, treatments, and outcomes related to this condition.
- Most cases were either "idiopathic" (no known cause) or caused by sarcoidosis, and many kids experienced complications, so doctors often used treatments like corticosteroids and methotrexate.
Objective: To examine whether the COVID-19 pandemic was associated with an increased incidence of uveitis in children.
Study Design: We performed a time-series analysis of patient records from a national, hospital-based, French surveillance system. All children hospitalized for uveitis in France between January 2012 and March 2022 were included.
To suggest a unique missense variant candidate based on long-term ophthalmological changes and associated systemic signs described in five patients from two unrelated families affected by an autosomal dominant multi-systemic disorder including Retinal dystrophy, Optic nerve oedema, Splenomegaly, Anhidrosis and migraine Headaches, called ROSAH syndrome, related to a unique missense variant in ALPK1 gene. Observational longitudinal follow-up study of unrelated families. Clinical analysis of ophthalmological and systemic examinations was performed, followed by genetic analysis, including targeted Next Generation Sequencing (NGS) and Whole-Genome Sequencing (WGS).
View Article and Find Full Text PDFPurpose: To describe a patient with hypertensive herpetic uveitis complicated by arterial retinal occlusions and a decompression retinopathy revealing a sickle cell trait.
Study Design: Case report.
Results: A 24-year-old African man presented with a hypertensive herpetic keratouveitis.
Article Synopsis
- Two cases of multiple evanescent white dot syndrome (MEWDS) were reported following the BNT162b2 mRNA COVID-19 vaccine, highlighting a potential link between the vaccine and ocular issues.
- A 40-year-old male and a 23-year-old female both experienced blurred vision and findings similar to MEWDS in their left eye after receiving the vaccine.
- Imaging showed that the eye anomalies resolved on their own within six weeks, pointing to possible inflammation or immune response related to the vaccine as a cause for these effects.
Article Synopsis
- The study examined the use of Tumor Necrosis Factor inhibitors (anti-TNF) to treat inflammatory choroidal neovascularization (CNV) in children under 16 years old.
- Three pediatric patients received various treatments, including anti-TNF additives, after experiencing persistent leakage.
- Results indicated that four out of five affected eyes showed improved vision and reduced fluid, demonstrating that anti-TNF agents are effective and safe for managing this condition in young patients.*
Article Synopsis
- The study aimed to compare the relapse rates of sight-threatening noninfectious uveitis (NIU) in patients treated with either infliximab (IFX) or adalimumab (ADA).
- It observed 330 patients, noting that 13% experienced a relapse within 6 months, with IFX showing significantly lower relapse risk compared to ADA.
- Behçet disease was linked to better treatment outcomes, including higher complete response rates and lower relapse rates when treated with anti-TNF-α agents.
Background: Acute macular neuroretinopathy (AMN) is an increasingly diagnosed disorder associated with several diseases. The aim of this study was to report the incidence of AMN cases diagnosed during the 2020 coronavirus disease 2019 (COVID-19) pandemic year in a French hospital, and to describe their different forms.
Methods: All patients diagnosed between 2019 and 2020, in Paris Rothschild Foundation Hospital, with AMN, paracentral acute middle maculopathy (PAMM) and multiple evanescent white dot syndrome (MEWDS) were retrospectively collected using the software Ophtalmoquery (Corilus, V1.
Describe our experience with tocilizumab in the treatment of refractory relapsing polychondritis with ocular involvement. Retrospective consecutive interventional case series that included all patients that received tocilizumab for the treatment of relapsing polychondritis with ocular manifestations. Three cases were selected and the duration of tocilizumab treatment ranged from 1 to 2 years.
View Article and Find Full Text PDF: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin.: Multicenter retrospective study of 38 patients with at least one test, either HCMV-positive PCR or GWc.: Features of Posner-Schlossman syndrome were observed in 50% of the eyes, Fuchs heterochromic iridocyclitis in 13% of the eyes, chronic nonspecific anterior uveitis in 21% of the eyes, and corneal endotheliitis in 18% of the eyes.
View Article and Find Full Text PDFArticle Synopsis
- Crystal sorting histiocytosis (CSH) is a rare condition marked by the buildup of monoclonal immunoglobulin crystals in macrophages, leading to various symptoms depending on the affected organs; this case highlights a patient diagnosed with multiple myeloma associated with CSH and ocular issues.
- A 60-year-old male experienced worsening vision over two years, with eye exams revealing swelling and crystalline deposits, alongside laboratory tests indicating nephrotic syndrome and renal issues, ultimately leading to a diagnosis of IgG kappa multiple myeloma.
- The patient underwent chemotherapy but, while there was some improvement in eye swelling, he ultimately progressed to end-stage renal failure requiring dialysis, demonstrating the complex impacts of paraprotein-related conditions
Purpose Of Review: Checkpoint inhibitors have been increasingly considered as new targets for cancer therapies. Patients receiving checkpoint inhibitors develop many immune-related adverse events (IRAEs). However, ophthalmic IRAEs are rare and have been reported in less than 1% of patients.
View Article and Find Full Text PDFA case of neurosyphilis revealed by acute exudative polymorphous vitelliform maculopathy.
Ophthalmic Surg Lasers Imaging Retina
April 2014
The authors report the case of a healthy 56-year-old man presenting with bilateral vision loss. Clinical features were consistent with the diagnosis of acute exudative polymorphous vitelliform maculopathy (AEPVM). The patient returned 10 days later with bilateral anterior granulomatous uveitis, and the inflammatory work-up revealed treponemal antibodies in the serum and spinal fluid, consistent with a diagnosis of active neurosyphilis.
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