Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia.

Importance: Depression has been identified as a risk factor for dementia. However, most studies have measured depressive symptoms at only one time point, and older adults may show different patterns of depressive symptoms over time.

Objective: To investigate the association between trajectories of depressive symptoms and risk of dementia in older adults.

Connections between sleep and cognition in older adults.

Sleep disturbances and cognitive impairment are common in older adults. Mounting evidence points to a potential connection between sleep and cognitive function. Findings from observational studies support a role for sleep disturbances (particularly for sleep duration, sleep fragmentation, and sleep-disordered breathing) in the development of cognitive impairment.

Effect of socioeconomic disparities on incidence of dementia among biracial older adults: prospective study.

Objective: To examine whether observed differences in dementia rates between black and white older people living in the community could be explained by measures of socioeconomic status (income, financial adequacy, education, and literacy) and health related factors.

Design: Prospective cohort study.

Setting: General community from two clinic sites in the United States (Pittsburgh, Pennsylvania and Memphis, Tennessee).

Anemia and risk of dementia in older adults: findings from the Health ABC study.

Objective: To determine whether anemia is associated with incident dementia in older adults.

Methods: We studied 2,552 older adults (mean age 76.1 years; 38.

Association between hypoglycemia and dementia in a biracial cohort of older adults with diabetes mellitus.

Importance: Hypoglycemia commonly occurs in patients with diabetes mellitus (DM) and may negatively influence cognitive performance. Cognitive impairment in turn can compromise DM management and lead to hypoglycemia.

Objective: To prospectively evaluate the association between hypoglycemia and dementia in a biracial cohort of older adults with DM.

Macro- and microstructural magnetic resonance imaging indices associated with diabetes among community-dwelling older adults.

Objective: To better understand the association between diabetes and cognitive impairment, we evaluated macro- and microstructural brain MRI measures for the total brain and regions of interest (ROIs) in a group of community-dwelling elders with and without diabetes.

Research Design And Methods: MRI measures were obtained on 308 elders (mean age 83.3 years; n = 85 with diabetes) from the Health ABC Healthy Brain Substudy.

Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia.

Objectives: To determine if prevalent and incident diabetes mellitus (DM) increase risk of cognitive decline and if, among elderly adults with DM, poor glucose control is related to worse cognitive performance. DESIGN Prospective cohort study.

Setting: Health, Aging, and Body Composition Study at 2 community clinics.