Post-Penetrating Keratoplasty Assessment of Endothelial Function With a Scleral Lens Challenge.

Patients who have undergone penetrating keratoplasty may have corneal edema because of endothelial cell dysfunction. Scleral lens wear may exacerbate edema, particularly if lens fit is suboptimal. Distinguishing between edema because of inherent endothelial cell dysfunction and swelling because of scleral lens-related hypoxia can be challenging.

Patient-Reported Dry Eye Treatment and Burden of Care.

Objectives: Dry eye is a common condition that can decrease the quality of life. This survey-based study of persons with dry eye investigated self-reported treatments (initial, current), out-of-pocket expenses, time spent on self-management, sources of care, and sources of information about their condition.

Methods: Online dry eye newsletters and support groups were emailed a link to an electronic survey asking members to participate.

Process and Outcomes of Fitting Corneoscleral Profilometry-Driven Scleral Lenses for Patients With Ocular Surface Disease.

Objectives: To assess the feasibility of obtaining cornea scleral profile (CSP) measurements using Scheimpflug imaging and report on the fitting process of free-form custom scleral lenses (SLs) for patients with ocular surface disease (OSD).

Methods: This prospective study of patients fit with free-form SLs collected data on the following: demographics, indications for wear, corneal and scleral tomography, scan acquisition process, and SL fitting process.

Results: Cornea scleral profile scans were acquired on 15 eyes of nine patients.

Patient Experiences With Therapeutic Contact Lenses and Dry Eye Disease.

Objectives: To report patient-reported experiences with dry eye disease and therapeutic contact lenses.

Methods: A survey was distributed to patients with dry eye disease. Demographics, Ocular Surface Disease Index (OSDI), systemic disease, contact lens history, and burden of care information were collected.

Ten-Year Changes in Vision, Refractive Error, and Corneal Thickness After Descemet Stripping Automated Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy.

Purpose: The goal of this study was to determine changes in best-corrected visual acuity (BCVA), refractive error, and central corneal thickness (CCT) during the first decade after Descemet stripping automated endothelial keratoplasty (DSAEK).

Methods: Outcomes of all consecutive eyes undergoing DSAEK for Fuchs endothelial corneal dystrophy (FECD) were reviewed; eyes with untreatable comorbidities before DSAEK were excluded. DSAEK was performed through a temporal incision and all eyes were pseudophakic postoperatively.

Current Trends in Scleral Lens Prescription, Management, and Evaluation.

Objectives: To report current trends in scleral contact lens prescription and management, including lens designs prescribed, care products recommended, and procedures performed during routine scleral lens (SL) evaluation.

Methods: An online survey was designed by the Scleral Lenses in Current Ophthalmic Practice Evaluation study team and administered to eye care practitioners attending a specialty contact lens meeting. The survey was available from November 8, 2019, through March 31, 2020.

Survey-Based Estimation of Corneal Complications Associated with Scleral Lens Wear.

The benefits of scleral lens (SL) wear have been described in cross-sectional and retrospective studies; however, the frequency of complications associated with SL wear has not, to the best of our knowledge, been determined. From a survey of SL practitioners, we estimated the period prevalence over 1 year of corneal complications that required SL wearers to discontinue lens wear. In a sample of 72,605 wearers, SL wear was discontinued for the following complications: corneal edema, 1.

Trends in Scleral Lens Fitting Practices: 2020 Scleral Lenses in Current Ophthalmic Practice Evaluation Survey.

Objectives: To explore trends in demographic characteristics of scleral lens (SL) practitioners and primary indications for SL fitting over 5 years.

Methods: An online survey similar to the 2015 Scleral Lenses in Current Ophthalmic Practice Evaluation (SCOPE) study was designed and administered from November 8, 2019, through March 31, 2020, to attendees at two international contact lens meetings, members of the Scleral Lens Education Society, and participants in the 2015 SCOPE study. Practitioners reporting at least five completed SL fits were included in the analysis.

Tear Exchange, Intraocular Pressure, and Wear Characteristics of Quadrant-specific Versus Spherical Haptic Scleral Lenses.

Objectives: To compare scleral lenses (SLs) with a quadrant-specific (study lens) or a spherical (habitual lens) landing zone in a crossover study.

Methods: Seven participants (eight eyes) wore each of two lenses for 2 weeks before measurements. We measured visual acuity, contrast sensitivity, intraocular pressure (IOP), fluid reservoir clearance, corneal thickness, tear exchange, and lens experience.

Microbial Keratitis Associated With Penetrating Keratoplasty and Scleral Lens Wear: A Case Series.

Objectives: To report on microbial keratitis (MK) in three scleral lens (SL) wearers who had undergone penetrating keratoplasty (PKP).

Methods: This retrospective case series describes 3 cases of MK in patients who wore SLs after PKP.

Results: All three patients wore SLs for visual rehabilitation for corneal irregularity induced by PKP; all three also had concurrent ocular surface disease (keratoconjunctivitis sicca and corneal exposure).

Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype.

Autosomal dominant polycystic kidney disease (ADPKD), characterized by progressive cyst formation/expansion, results in enlarged kidneys and often end stage kidney disease. ADPKD is genetically heterogeneous; PKD1 and PKD2 are the common loci (∼78% and ∼15% of families) and GANAB, DNAJB11, and ALG9 are minor genes. PKD is a ciliary-associated disease, a ciliopathy, and many syndromic ciliopathies have a PKD phenotype.

Quadrant-Specific Changes in Corneal and Tear Fluid Reservoir Thickness for After 2 Hours of Wear.

Objective: To measure corneal swelling and thickness of the tear fluid reservoir (TFR) after wearing scleral lenses (SLs).

Methods: Thirty-five participants had 1 eye fitted with each of three SLs (15.0-mm Jupiter, 18.

Scleral lens prescription and management practices: Emerging consensus.

Purpose: To describe international scleral lens prescription and management practices across multiple practice types.

Methods: For this cross-sectional study, scleral lens practitioners were asked to complete an electronic survey that requested information about a single scleral lens patient. Data collected included practitioner demographics (practice type, country, years of experience) and patient indications for scleral lens wear, fitting process, lens design, and care products.

Multicenter review of impression-based scleral devices.

Objective: To describe outcomes using impression based-scleral devices for the management of anterior segment disease.

Methods: Retrospective chart review identified all patients who were fitted with impression-based scleral devices between January 1, 2013 and June 30, 2019 at three specialty contact lens practices. Patient demographic data, indication for device use, visual and physiological outcomes, as well as details of the fitting process and survival of device use were determined.

Current U.S. based optometric scleral lens curricula and fitting recommendations: SCOPE educators survey.

Objectives: To describe current components of scleral lens curricula at U.S. based optometry colleges and universities.

Comparison of Pneumatonometry and Transpalpebral Tonometry Measurements of Intraocular Pressure during Scleral Lens Wear.

Significance: As scleral lens wear becomes more common, understanding the impact of these lenses upon ocular physiology is critically important. Studies on the effect of scleral lens wear upon intraocular pressure (IOP) have used different instruments and have reported conflicting results.

Purpose: The purpose of this study was to compare assessment of IOP during scleral lens wear using pneumatonometry and transpalpebral tonometry.

Factors associated with patient-reported midday fogging in established scleral lens wearers.

Purpose: To estimate the prevalence of patient-reported midday fogging and to identify risk factors for midday fogging.

Method: A multicenter, cross-sectional study was conducted with an electronic survey that was distributed to scleral lens practitioners. The survey asked them to describe their most recently examined established scleral lens patient.

Changes in Optical Density of Postlens Fluid Reservoir During 2 Hours of Scleral Lens Wear.

Objectives: Debris accumulation in the postlens fluid reservoir during scleral lens wear is clinically observed. We evaluated a method to quantify increases in turbidity of the postlens fluid reservoir by assessing changes in optical density of the fluid over time and compared these changes during 2 hr of scleral lens wear using three different lens designs.

Methods: Thirty-five patients (age, mean [SD], 29 [7] years) with no history of eye disease were enrolled in the study.

Scleral Lenses in the Management of Corneal Irregularity and Ocular Surface Disease.

Purpose: To describe current practice patterns regarding the use of scleral lens therapy in the management of corneal irregularity and ocular surface disease among eye care providers who fit scleral lenses.

Methods: The Scleral Lenses in Current Ophthalmic Practice: an Evaluation (SCOPE) study group conducted an electronic survey of eye care providers from January 15 to March 31, 2015. Respondents ranked management options for corneal irregularity in the order in which they would generally consider their use.

Demographic Characteristics and Prescribing Patterns of Scleral Lens Fitters: The SCOPE Study.

Objectives: This study reports demographic characteristics of scleral lens providers and indications for scleral lens prescription as assessed by a worldwide online survey.

Methods: The Scleral Lenses in Current Ophthalmic Practice: an Evaluation (SCOPE) study group designed the online survey regarding current scleral lens prescription and management practices. The Mayo Clinic Survey Research Center administered the survey, which was open from January 15 to March 31, 2015.

Scleral Lens Prescription and Management Practices: The SCOPE Study.

Objectives: To assess current scleral lens prescription and management practices by conducting an international online survey of eye care providers.

Methods: The SCOPE (Scleral Lenses in Current Ophthalmic Practice: an Evaluation) study group designed and administered an online survey regarding current scleral lens prescription and management practices. The survey was open from January 15 to March 31, 2015, and generated 723 responses from individuals who had fit at least 5 patients with scleral lenses.

Region-Specific Changes in Postlens Fluid Reservoir Depth Beneath Small-Diameter Scleral Lenses Over 2 Hours.

Objectives: Scleral lenses settle on the eye with time, and the depth of the postlens fluid reservoir decreases. We measured changes in central, superior, inferior, temporal, and nasal clearance beneath a small-diameter scleral lens after 2 hr of lens wear in healthy eyes.

Methods: Thirty-one participants (age, mean±SD, 29±7 years) with no history of eye disease or scleral lens wear were fitted with a 15-mm scleral lens in 1 eye.

Intraocular Pressure After 2 Hours of Small-Diameter Scleral Lens Wear.

Objectives: Compression of episcleral veins or deformation of tissue in the Schlemm's canal beneath the landing zone of scleral lenses could elevate intraocular pressure (IOP). We examined the effect of 2 hr of small-diameter scleral lens wear on IOP.

Methods: Twenty-nine participants, 29 ± 6 years old (mean ± SD) who experienced no history of eye disease or scleral lens wear, were included in the study.

Ocular Graft-Versus-Host Disease: A Review.

Hematopoietic stem cell transplantation is important in the management of several lymphoproliferative and bone marrow disorders. Graft-versus-host disease (GVHD) involves inflammatory manifestations that arise after transplant and can affect many organs. Ocular manifestations of GVHD are common, and eye care providers must understand this disease entity.