The effect of Diprivan (propofol) on phosphorylcholine surfaces during cardiopulmonary bypass--an in vitro investigation.

It is well known that extracorporeal surfaces have the ability to bind such drugs as fentanyl, nitroglycerine and propofol. Adsorption of the injectable anesthetic agent Diprivan (propofol) onto uncoated and heparin-coated extracorporeal surfaces during cardiopulmonary bypass (CPB) has been previously investigated; however, propofol adsorption onto synthetic-coated extracorporeal surfaces has not been published previously. The focus of this investigation was on the interaction of propofol and the synthetic biomimetic coating from the Sorin Group called Mimesys (phosphorylcholine (PC)).

Post-arterial filter gaseous microemboli activity of five integral cardiotomy reservoirs during venting: an in vitro study.

During a previously published study on gaseous microemboli (GMEs) and perfusionist interventions, it was noted that emboli could be detected after the arterial filter when blood/air challenges entered the membrane oxygenator's integral cardiotomy. The findings indicated that further study into the oxygenator's integral cardiotomy reservoir was warranted. This is the first know published report that connects the vent return to GME activity after the arterial filter.