Publications by authors named "Cherdpong Choodet"
Cholangiocarcinoma (CCA), an epithelial biliary tract malignancy, is a significant health concern in the Greater Mekong Subregion, particularly in northeastern Thailand. Prior to the development of advanced stages, CCA is typically asymptomatic, thereby limiting treatment options and chemotherapeutic effectiveness. Ursolic acid (UA), a triterpenoid derived from plants, was previously discovered to inhibit CCA cell growth through induction of apoptosis.
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- - The elevated levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) in biological samples indicate oxidative stress and serve as an important biomarker for various diseases.
- - The study details the mechanisms of an aptasensor utilizing gold nanoparticles (AuNPs) for detecting 8-oxo-dG, revealing a binding process that includes stages of adsorption, binding, and stabilization, with key hydrogen bonding interactions.
- - A modified version of the anti-8-oxo-dG aptamer was created to enhance the performance of the colorimetric aptasensor, which was validated through experiments and holds potential for developing easy-to-use sensors for detection.
The concentration of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) in urine or serum is associated with the degree of oxidative damage of DNA and broadly used as a sensitive biomarker for various diseases. However, determination of a low concentration of 8-oxo-dG in biosamples is not an easy task owing to the complexity of coexisting substances. Herein, we design an aptasensor based on aptamer-mediated aggregation of cysteamine-capped gold nanoparticles (Cyst/AuNPs) for the detection of 8-oxo-dG by molecular dynamics simulation.
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