Inhibition of Urban Particulate Matter-Induced Airway Inflammation by RIPK3 through the Regulation of Tight Junction Protein Production.

Urban particulate matter (UPM) is a high-hazard cause of various diseases in humans, including in the respiratory tract, skin, heart, and even brain. Unfortunately, there is no established treatment for the damage caused by UPM in the respiratory epithelium. In addition, although RIPK3 is known to induce necroptosis, its intracellular role as a negative regulator in human lungs and bronchial epithelia remains unclear.

Clinical characteristics of pediatric patients infected with SARS-CoV-2 versus common human coronaviruses: a national multicenter study.

Background: Human coronaviruses (HCoV) cause mild upper respiratory infections; however, in 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged, causing an acute respiratory disease pandemic. Coronaviruses exhibit marked epidemiological and clinical differences.

Purpose: This study compared the clinical, laboratory, and radiographic findings of children infected with SARS-CoV-2 versus HCoV.

Gearbox Fault Identification Model Using an Adaptive Noise Canceling Technique, Heterogeneous Feature Extraction, and Distance Ratio Principal Component Analysis.

Using an adaptive noise canceling technique (ANCT) and distance ratio principal component analysis (DRPCA), this paper proposes a new fault diagnostic model for multi-degree tooth-cut failures (MTCF) in a gearbox operating at inconsistent speeds. To account for background and disturbance noise in the vibration characteristics of gear failures, the proposed approach employs ANCT in the first stage to optimize vibration signals. The ANCT applies an adaptive denoising technique to each basic frequency segment in the whole frequency response of vibrations.

A Method for Pipeline Leak Detection Based on Acoustic Imaging and Deep Learning.

This paper proposes a reliable technique for pipeline leak detection using acoustic emission signals. The acoustic emission signal of a pipeline contains leak-related information. However, the noise in the signal often obscures the leak-related information, making traditional acoustic emission features, such as count and peaks, less effective.

Shoulder Pain Treated by Manual Acupuncture and Pharmacopuncture Following Origin/Insertion Technique of Applied Kinesiology: A Case Series of Two Patients.

The aim of this study was to report on the improvement of shoulder pain resulting from disorders of the rotator cuff such as impingement syndrome and adhesive capsulitis, by manual acupuncture (MA) and pharmacopuncture (PA) following origin/insertion technique (OIT) of applied kinesiology (AK). Two patients were treated with MA and PA after OIT on shoulder muscles. The Numerical Rating Scale and the assessment of the Japanese Orthopedic Association scores were used to assess the pain, and ultrasound images were taken to compare treatment outcome.

Novel Bearing Fault Diagnosis Using Gaussian Mixture Model-Based Fault Band Selection.

This paper proposes a Gaussian mixture model-based (GMM) bearing fault band selection (GMM-WBBS) method for signal processing. The proposed method benefits reliable feature extraction using fault frequency oriented Gaussian mixture model (GMM) window series. Selecting exclusively bearing fault frequency harmonics, it eliminates the interference of bearing normal vibrations in the lower frequencies, bearing natural frequencies, and the higher frequency contents that prove to be useful only for anomaly detection but do not provide any insight into the bearing fault location.

Epidemiology and clinical features of common community human coronavirus disease.

Background: We would evaluate the epidemiology, clinical aspects, and prognostic factors of patients of all ages admitted with human corona virus (HCoV).

Methods: This study was retrospectively performed at five university teaching hospitals between 1st January 2018 and 31th March 2020. Routine molecular testing using for multiplex real-time reverse transcription-polymerase chain reaction (RT-PCR) methods was conducted on the respiratory viruses.

Re-use of health masks after autoclaving.

With the rapid global spread of the new coronavirus and risk of pneumonia from COVID-19 infection, wearing a mask has become an essential defense for all frontline doctors, nurses, and healthcare professionals. Plus, the rise in demand for masks from the general public means the worldwide supply of masks is insufficient, which has led to an increase in the reuse of disposable masks. Therefore, this study compared the impact of autoclaving (steaming) and 70% ethyl alcohol treatment for decontaminating masks, as both methods can easily be used at home.

Construction of a Sensitive and Speed Invariant Gearbox Fault Diagnosis Model Using an Incorporated Utilizing Adaptive Noise Control and a Stacked Sparse Autoencoder-Based Deep Neural Network.

Gearbox fault diagnosis based on the analysis of vibration signals has been a major research topic for a few decades due to the advantages of vibration characteristics. Such characteristics are used for early fault detection to guarantee the enhanced safety of complex systems and their cost-effective operation. There exist many fault diagnosis models that have been developed for classifying various fault types in gearboxes.

Deep Learning-Based Bearing Fault Diagnosis Method for Embedded Systems.

Bearing elements are vital in induction motors; therefore, early fault detection of rolling-element bearings is essential in machine health monitoring. With the advantage of fault feature representation techniques of time-frequency domain for nonstationary signals and the advent of convolutional neural networks (CNNs), bearing fault diagnosis has achieved high accuracy, even at variable rotational speeds. However, the required computation and memory resources of CNN-based fault diagnosis methods render it difficult to be compatible with embedded systems, which are essential in real industrial platforms because of their portability and low costs.

Down-regulation of diesel particulate matter-induced airway inflammation by the PDZ motif peptide of ZO-1.

Although diesel airborne particulate matter (PM2.5) has been known to play a role in many human diseases, there is no direct evidence that therapeutic drugs or proteins can diminish PM2.5-induced diseases.

Completion rate of latent tuberculosis infection treatment in patients aged 65 years and older.

Introduction: There are insufficient data on the treatment of latent tuberculosis infection (LTBI) in elderly patients. We investigated the completion rate of treatment in elderly LTBI patients.

Methods: A retrospective multicentre study was conducted at five university hospitals in South Korea.

Mortality and Prognostic Prediction in Very Elderly Patients With Severe Pneumonia.

Introduction: Although prognostic prediction scores for pneumonia such as CURB-65 score or pneumonia severity index (PSI) are widely used, there were a few studies in very elderly patients. The aim of the study was to validate prognostic prediction scores for severe pneumonia and investigate risk factors associated with in-hospital mortality of severe pneumonia in very elderly patients.

Methods: During the 6-year study period (from October 2012 to May 2018), 160 patients aged 80 or older admitted to medical intensive unit were analyzed retrospectively.

Study on the Validity of Surface Electromyography as Assessment Tools for Facial Nerve Palsy.

Objectives: The purpose of this study was to find out validity of Surface Electromyography(sEMG) compared with Nerve Conduction Study and clinical assessment scale as assessment factors for facial palsy.

Methods: We investigated 50 cases of patients with peripheral facial palsy who had records of sEMG and NCS to check. Then we analyzed the correlation between sEMG and NCS that carried out around 1 week after onset.

Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-κB, blocking the TLR4 pathway and reducing ROS generation.

Isorhamnetin, which is a flavonoid predominantly found in fruits and leaves of various plants, including Hippophae rhamnoides L. and Oenanthe javanica (Blume) DC, is known to possess various pharmacological effects. However, the anti‑inflammatory potential of isorhamnetin remains poorly studied.

Usefulness of the procalcitonin test in young febrile infants between 1 and 3 months of age.

Purpose: To study the usefulness of the procalcitonin (PCT) test in young febrile infants between 1 and 3 months of age.

Methods: We evaluated the medical records of 336 febrile infants between 1 and 3 months of age who visited the Emergency Department or outpatient department of Samsung Changwon Hospital from May 2015 to February 2017, and analyzed the clinical characteristics between infants in the serious bacterial infection (SBI) group and non-SBI group.

Results: Among the 336 infants, 38 (11.

Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT-116 cells through down-regulation of prostaglandin E2 receptor EP4.

Prostaglandin E2 (PGE2), a major product of cyclooxygenase-2 (COX-2), plays an important role in the carcinogenesis of many solid tumors, including colorectal cancer. Because PGE2 functions by signaling through PGE2 receptors (EPs), which regulate tumor cell growth, invasion, and migration, there has been a growing amount of interest in the therapeutic potential of targeting EPs. In the present study, we investigated the role of EP4 on the effectiveness of cordycepin in inhibiting the migration and invasion of HCT116 human colorectal carcinoma cells.

The Impact of Air Pollution, Including Asian Sand Dust, on Respiratory Symptoms and Health-related Quality of Life in Outpatients With Chronic Respiratory Disease in Korea: A Panel Study.

Objectives: Air pollution is a growing concern in Korea because of transboundary air pollution from mainland China. A panel study was conducted to clarify the effects of air pollution on respiratory symptoms and health-related quality of life (HR-QoL) in outpatients with and without chronic obstructive pulmonary disease (COPD) in Korea.

Methods: Patients filled out a questionnaire including self-reported HR-QoL in February and were followed up in May and July.

The Effect of Hidden Female Smoking on the Association between Smoking and Asthma.

Background: The association between smoking and asthma remains controversial. In our previous study, we were not able to show an association between asthma and smoking in Korean adults. One Korean study demonstrated underreporting of smoking history by female adults.