Publications by authors named "Cheol Bin Eom"
Liver fibrosis occurs during wound healing after repeated liver injury and is characterized by extensive extracellular matrix deposition. We previously identified hyaluronan synthase 2 (HAS2) as a driver of liver fibrosis and hepatic stellate cell (HSC) activation. Developing strategies to suppress HSC activation is key to alleviating liver fibrosis, and HAS2 is an attractive candidate for intervention.
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- Alcoholic liver disease is mainly caused by excessive alcohol consumption, leading to endoplasmic reticulum (ER) stress, which involves a protein called ERdj5 that needs further research regarding its role in this condition.
- In studies with mice and humans suffering from alcoholic hepatitis, levels of ERdj5 were found to increase significantly, and its absence worsened alcohol-related liver damage and oxidative stress.
- The findings indicate that ERdj5 may help protect the liver by influencing the Nrf2 pathway and maintaining antioxidant levels, suggesting its potential as a therapeutic target for alcoholic liver disease.