Publications by authors named "Chenyu Wu"

After spinal cord injury (SCI), microglia polarization plays an important role in spinal cord recovery and axon regeneration. In this study, we conducted mRNA microarrays to identify genes associated with different microglial phenotypes. The results showed a correlation between microglial polarization and the PI3K/AKT signaling pathway, a key regulator of inflammatory responses.

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The objective of this study is to develop a model that incorporates clinical measurements with 3D radiomic signatures extracted from CT images of oral and maxillofacial surgery patients to evaluate mask ventilation. A prospective cohort trial was conducted to enroll patients scheduled for oral and maxillofacial surgery. After obtaining informed consent, clinical measurements and head and neck CT images were collected.

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Background: Dubin-Johnson syndrome (DJS), a rare autosomal recessive liver condition, is caused by biallelic loss-of-function mutations of the gene. This study aimed to investigate genetic variations in the drug efflux transporter (MRP2) gene in patients with DJS and to characterise the expression and mechanism of the gene variant.

Methods: Trio whole exome sequencing was performed in the family to identify the genetic causes.

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Objectives: COTI-2, an innovative oral homocysteine, has shown promising antitumor results on multiple types of cancer. However, its effects in treating bladder cancer (BCa) and the underlying molecular mechanisms have not been elucidated. The present study aimed to explore the antitumor effects of COTI-2 on BCa and the potential mechanisms.

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Osteoarthritis (OA) is a prevalent degenerative disease that lacks effective therapy. Oxidative stress is one of the major factors contributing to OA; however, treatments targeting oxidative stress are still lacking. In the current study, we established an oxidative stress-induced cell death model in chondrocytes and screened drugs that may suppress oxidative stress-induced cell death.

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Spinal cord injury (SCI) is a potentially fatal condition that often results in loss of motor and sensory functions, thereby significantly burdening global health initiatives. Urolithin A (UA), an intestinal microbial metabolite of ellagic acid, is known for its potent anti-inflammatory properties in chronic inflammation contexts. UA treatment in humans induces a molecular signature of improved mitochondrial and cellular health.

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Diclofenac (DIC) is a nonsteroidal anti-inflammatory drug with poor tabletability and water solubility. In the present study, a new diclofenac-picolinamide cocrystal (DIC-PIC) was prepared to simultaneously improve its tabletability and solubility. The cocrystal was characterized using multiple techniques, such as X-ray diffraction, thermal methods and spectral analyses.

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Background/purpose: This multi-institutional study was aimed to analyze prognostic factors of completely resected early stage thymoma.

Methods: Patients with surgically treated early stage thymoma between 1988 and 2019 were enrolled. Statistical associations were evaluated using the χ test, Fisher's exact test, and Student's t-test.

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Article Synopsis
  • The integration of machine learning potentials (MLPs) in heterogeneous catalysis research helps identify active sites and enhances understanding of catalytic processes.
  • MLPs leverage large databases from density functional theory (DFT) to predict atomic configurations and energies accurately, enabling simulations of larger systems and longer timeframes.
  • The review highlights advancements in MLP usage, showcases successful case studies in catalyst modeling, and discusses challenges within this approach.
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  • Oxidative stress hinders the healing process of diabetic wounds, and procyanidins (PC) show potential but are underutilized in this context.
  • A study identified Baicalein (BAI) as the most effective antioxidant from a natural product library, leading to the creation of BAI-PC Polyphenolic nanovesicles (BPPNs) that combat oxidative stress.
  • The combination of PC and BAI enhances healing through mechanisms that improve blood vessel formation and reduce oxidative damage in diabetic wounds.
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Objectives: Chest computed tomography (CT) can diagnose and assess the severity of pulmonary contusions. However, in cases of severe lung contusion, the total lung volume ratio may not accurately predict severity. This study investigated the association between life-threatening hemoptysis and chest CT imaging data on arrival at the emergency department in patients with pulmonary contusions or lacerations due to blunt chest injury.

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The treatment of complex or chronic skin wounds caused by burns, trauma, surgery, and genetic disorders has been a worldwide challenge. Small intestinal submucosa (SIS) is a biological material that is widely used in wound healing. How to further expand the wound healing application of SIS, especially in repairing infected wounds, remains a hot research topic for many tissue engineering and biomaterial scholars focusing on skin regeneration.

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  • Intervertebral disc degeneration (IVDD) is a major cause of low back pain, with disc cells playing a vital role in maintaining the disc's structure and function while also participating in important physiological processes.
  • Oxidative stress can damage mitochondria within these cells, leading to inflammation, DNA damage, and accelerated disc degeneration.
  • The review discusses the relationship between oxidative stress, mitochondrial dysfunction, and IVDD, suggesting targeted therapies such as antioxidants to address these issues and improve treatment outcomes.
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Severe acute pancreatitis (SAP) is an acute inflammatory injury disease with significant mortality rate and currently without effective strategy being available. Inflammation and oxidative stress play central roles in the etiology of SAP. Micheliolide (MCL), an active monomeric component isolated from Michelia champaca, has been proved its multiple therapeutic properties including anti-inflammatory, antioxidant and anti-cancer.

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Iron carbodiimide (FeNCN) often suffers from unstable interfacial structure with an unexpected failure of Na-ion storage performance. In this work, CoO particles were deposited on the surface of FeNCN. This CoO nanolayer led to the formation of a NaCO-rich inorganic component SEI film to enhance the stability of a promoted-loading FeNCN electrode interface with fast Na migration pathway.

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Background: Reactive astrocytes participate in various pathophysiology after subarachnoid hemorrhage (SAH), including neuroinflammation, glymphatic-lymphatic system dysfunction, brain edema, BBB disruption, and cell death. Astrocytes transform into two new reactive phenotypes with changed morphology, altered gene expression, and secretion profiles, termed detrimental A1 and beneficial A2. This study investigates the effect of 67LR activation by PEDF-34, a PEDF peptide, on neuroinflammation and astrocyte polarization after the experimental SAH.

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This study aimed to construct a non-invasive diagnostic nomogram based on high-frequency ultrasound and magnetic resonance imaging results for early liver cirrhosis patients with chronic hepatitis B (CHB) which cannot be detected by conventional non-invasive examination methods but can only be diagnosed through invasive liver puncture for pathological examination. 72 patients with CHB were enrolled in this prospective study, and divided into S4 stage of liver cirrhosis and S0-S3 stage of non-liver cirrhosis according to pathological findings. Binary logistic regression analysis was performed to identify independent predictors, and a diagnostic nomogram was constructed for CHB-related early cirrhosis.

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: Following spinal cord injury (SCI), autophagy plays a positive role in neuronal protection, whereas pyroptosis triggers an inflammatory response. Ginsenoside-Rh2 (GRh2), known for its neuroprotective effects, is considered a promising drug. However, the exact molecular mechanisms underlying these protective effects remain unclear.

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Article Synopsis
  • Spinal cord injury (SCI) can result in permanent paralysis and various dysfunctions, with mitochondria playing a vital role in its pathogenesis; however, effective mitophagy-targeted treatments are currently limited.
  • In this study, researchers assessed the effects of 20-Deoxyingenol (20-DOI) on SCI in a rat model, finding that it improved neural cell survival and functional recovery post-injury.
  • The findings suggest that 20-DOI enhances mitophagy and reduces apoptosis by restoring autophagic flux and promoting TFEB nuclear translocation, indicating its potential as a promising treatment for spinal cord injury.
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The photocatalyst (PC) zinc tetraphenylporphyrin (ZnTPP) is highly efficient for photoinduced electron/energy transfer reversible addition-fragmentation chain transfer (PET-RAFT) polymerization. However, ZnTPP suffers from poor absorbance of orange light by the so-called Q-band of the absorption spectrum (maximum absorption wavelength λmax = 600 nm, at which molar extinction coefficient εmax = 1.0×104 L/(mol·cm)), hindering photo-curing applications that entail long light penetration paths.

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Tumor heterogeneity is a complex and widely recognized trait that poses significant challenges in developing effective cancer therapies. In particular, many tumors harbor a variety of subpopulations with distinct therapeutic response characteristics. Characterizing this heterogeneity by determining the subpopulation structure within a tumor enables more precise and successful treatment strategies.

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The search for highly efficient and inexpensive electrocatalysts is crucial to the advancement of environmentally friendly and sustainable energy sources. Here, adopting a one-step hydrothermal method, we have effectively fabricated a self-supported multi-metal molybdenum-based oxide (FeCoNi-MoO) on nickel foam (NF). In addition to changing the catalyst's microstructure, the introducing of Fe and Co, enhanced its active center count, improved its electronic structure, and in turn reduced the difficulty for high-valence Ni and Fe species to form, which accelerates the oxygen evolution reaction (OER) kinetics by promoting the development of the actual active materials, NiOOH and FeOOH.

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Article Synopsis
  • Organic photocatalysts (PCs) are versatile tools in creating polymer products with specific characteristics, but more universal guidelines are needed for their effective design.
  • Current methods, which use redox potentials as descriptors for very similar PCs, do not work well for those with varied structures and components.
  • New descriptors that consider factors like binding and density overlap between PCs and initiators have been developed and successfully applied to improve understanding in photocatalytic systems like organocatalysed atom transfer radical polymerisation (O-ATRP).
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