Publications by authors named "Chenying Han"
Article Synopsis
- Hemorrhagic fever with renal syndrome (HFRS) is a serious illness in Eurasia with no specific treatments currently available, highlighting the need for safe and effective vaccines.
- Researchers developed three types of nucleic acid vaccine candidates (mRNA, naked DNA, and DNA in lipid nanoparticles) targeting the Hantaan virus to assess their potential against HFRS.
- All vaccine candidates successfully triggered strong immune responses similar to an existing inactivated vaccine, with the mRNA vaccine showing a robust T-helper 1 cell response and the DNA-LNP producing higher neutralizing antibodies, suggesting that combining these vaccines could enhance their effectiveness.
Follicular CD8 T cells promote immunoglobulin production and demyelination in multiple sclerosis and a murine model.
Biochim Biophys Acta Mol Basis Dis
October 2024
Article Synopsis
- Emerging evidence highlights the crucial role of a specific subset of CD8 T cells, called CD8CXCR5 T cells, in the development of multiple sclerosis (MS).
- These cells are found in higher numbers during the acute phase of MS and experimental models, with their presence linked to new lesions in the central nervous system and clinical severity.
- CD8CXCR5 T cells can activate B cells and boost the production of antibodies associated with the disease, suggesting they may contribute to CNS damage by increasing humoral immune responses.
Cervical cancer (CC) is the most common gynecologic malignancy, which seriously threatens the health of women. Lipid metabolism is necessary for tumor proliferation and metastasis. However, the molecular mechanism of the relationship between CC and lipid metabolism remains poorly defined.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system, ranking third for morbidity and mortality worldwide. At present, no effective control method is available for this cancer type. In tumor cells, especially iron metabolization, is necessary for its growth and proliferation.
View Article and Find Full Text PDF[Knockdown of IGF2BP2 inhibits colorectal cancer cell proliferation, migration and promotes tumor immunity by down-regulating MYC expression].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
April 2023
Objective To investigate the effect of insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) on the proliferation, migration and tumor immune microenvironment of colorectal cancer cells and its possible molecular mechanism. Methods The Cancer Genome Atlas (TCGA) database was used to analyze the expression levels of IGF2BP2 and MYC in colorectal cancer and adjacent tissues. The expression of IGF2BP2 in HCT-116 and SW480 human colorectal cancer cells was silenced by RNA interference (RNAi), and the silencing effect was detected by quantitative real-time PCR.
View Article and Find Full Text PDF[METTL14 promotes the proliferation and migration of cervical cancer cells by up-regulating mA Myc expression].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
February 2022
Objective To investigate the effect of methyltransferase-like 14 (METTL14) on the proliferation and metastasis of cervical cancer cells and its possible molecular mechanism. Methods The expression of METTL14 and Myc in cervical cancer tissues and normal tissues were analyzed using Gene Expression Omnibus (GEO) database and cervical cancer tissue microarray. The expression of METTL14 in HeLa and SiHa cells was silenced by small interfering RNA.
View Article and Find Full Text PDFEnhanced aerobic glycolysis constitutes an additional source of energy for tumor proliferation and metastasis. Human papillomavirus (HPV) infection is the main cause of cervical cancer (CC); however, the associated molecular mechanisms remain poorly defined, as does the relationship between CC and aerobic glycolysis. To investigate whether HPV 16/18 E6/E7 can enhance aerobic glycolysis in CC, E6/E7 expression was knocked down in SiHa and HeLa cells using small interfering RNA (siRNA).
View Article and Find Full Text PDFPreparation of antibodies against TXR1 and construction of a new DNA tumor vaccine.
Int Immunopharmacol
February 2022
Background: Taxol-resistance gene 1 (TXR1) is closely correlated with the paclitaxel resistance in the cancer chemotherapy. However, due to the lack of monoclonal antibodies (mAbs) with strong specificity and high sensitivity, little information is found about TXR1 target-related tumor therapy.
Methods: We developed an TXR1 recombinant DNA vaccine by inserting TXR1 DNA sequence into lysosome-associated membrane protein 1 (LAMP1).