Parkinson's disease (PD) is characterized by the accumulation of misfolded α-synuclein protein and the loss of dopaminergic neurons in the substantia nigra. Abnormal α-synuclein aggregates form toxic Lewy bodies, ultimately inducing neuronal injury. Mitochondrial dysfunction was reported to be involved in the neurotoxicity of α-synuclein aggregates in PD.
View Article and Find Full Text PDFThe current accuracy of speech recognition can reach over 97% on different datasets, but in noisy environments, it is greatly reduced. Improving speech recognition performance in noisy environments is a challenging task. Due to the fact that visual information is not affected by noise, researchers often use lip information to help to improve speech recognition performance.
View Article and Find Full Text PDFAt present, bone nonunion and delayed union are still difficult problems in orthopaedics. Since the discovery of bone morphogenetic protein (BMP), it has been widely used in various studies due to its powerful role in promoting osteogenesis and chondrogenesis. Current results show that BMPs can promote healing of bone defects and reduce the occurrence of complications.
View Article and Find Full Text PDFTumor resection and treatment of trauma-related regional large bone defects have major challenges in the field of orthopedics. Scaffolds that treat bone defects are the focus of bone tissue engineering. 3D printing porous titanium alloy scaffolds, prepared via electron beam melting technology, possess customized structure and strength.
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