Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol-polyethylene glycol-ginsenoside Rh2.

The aim of this study was to develop an amphipathic polyethylene glycol (PEG) derivative that was bi-terminally modified with celastrol and ginsenoside Rh2 (Celastrol-PEG-G Rh2). Such derivative was capable of forming novel, celastrol-loaded polymeric micelles (CG-M) for endo/lysosomal delivery and thereby synergistic treatment of lung cancer. Celastrol-PEG-G Rh2 with a yield of 55.

[Absorption and metabolism of flavonoids in Herba Epimedii via rat intestinal perfusion model].

Objective: To study the absorption and metabolism of five flavonoids of Herba Epimedii (icariin, epimedin A, epi-medin B, epimedin C and baohuoside I) in rat intestine.

Method: Using the rat intestinal perfusion model, the contents of the five flavonoids in perfusates were measured by HPLC and the permeability coefficients in different intestines were calculated.

Result: The permeabilities of five flavonoids in duodenum, jejunum, ileum, colon according to the sequence were as: icariin: 6.

[Comparison of two kinds of methods to prepare Chinese medicine Danggui Buxue formula pellets].

The pellet-preparating theories and processes of two kinds of methods of extrusion-spheronization and fluid-bed coating method were compared. The micromeritic properties, yield and in vitro dissolution of Danggui Buxue pellets prepared by the two methods were determined. Results showed that the Danggui Buxue pellets prepared by extrusion-spheronization were all spheral with smooth surface, the yield of those pellets was higher and in vitro dissolution of those pellets was more satisfactory.

[Pharmacokinetics of pueraria flavonoids from Pueraria lobata by anti-oxidant pharmacodynamics effect method].

Objective: To study the pharmacokinetics of pueraria flavonoids(PF) from Pueraria lobata.

Method: An anti-oxidant pharmacodynamics effect method was quoted to detect the antioxidant ability of PF contained in rats plasm after oral delivered, measures the fluorescence intensity, and calculates the concentration of components in plasma, then we can get the plot of the change of the content of PF contained in rats plasm, and then we can get the pharmacokinetics of Pueraria Flavonoids pellets.

Result: The AUC of Pueraria lobata isoflavone pellets is 4.