Elevated HMGB1 expression induced by hepatitis B virus X protein promotes epithelial-mesenchymal transition and angiogenesis through STAT3/miR-34a/NF-κB in primary liver cancer.

HBV infection plays a crucial role in primary liver cancer development. Also, HBV related liver cancer has higher invasiveness and earlier discovered distant metastasis. HBV-encoded X protein (HBx) exerts various biological functions on liver cancer progression, including proliferation, invasion, and venous metastasis.

Mesenchymal stem cells ameliorate lipid metabolism through reducing mitochondrial damage of hepatocytes in the treatment of post-hepatectomy liver failure.

Hepatectomy is an effective therapeutic strategy for many benign and malignant liver diseases, while the complexity of liver anatomy and the difficulty of operation lead to complications after hepatectomy. Among them, post-hepatectomy liver failure (PHLF) is the main factor threatening the life of patients. At present, liver transplantation is an effective approach for PHLF.

Protective Properties of FOXO1 Inhibition in a Murine Model of Non-alcoholic Fatty Liver Disease Are Associated With Attenuation of ER Stress and Necroptosis.

Aim: The pathogenesis of non-alcoholic fatty liver disease is currently unclear, however, lipid accumulation leading to endoplasmic reticulum stress appears to be pivotal in the process. At present, FOXO1 is known to be involved in NAFLD progression. The relationship between necroptosis and non-alcoholic steatohepatitis has been of great research interest more recently.

A Multiplexed SERS-Active Microneedle for Simultaneous Redox Potential and pH Measurements in Rat Joints.

To detect redox potential and pH simultaneously in rat joints, a surface-enhanced Raman scattering (SERS)-active microneedle was structured with two separate grooves containing redox-sensitive and pH-sensitive SERS probes, respectively. The multiplexed SERS-active microneedles brought the two SERS probes into muscles with minimal invasion to sense their redox status and pH in 5 min, and they also detected the dynamical evolution of redox status and pH in muscles. The multiplexed SERS-active microneedles were also inserted into rat joints to sense their redox status and pH, which lack flowable fluids.