Publications by authors named "Chenxue Yin"
Cancer-Associated Endocrine Cells Participate in Pancreatic Carcinogenesis.
Gastroenterology
November 2024
Article Synopsis
- The study examines the interactions between the endocrine and exocrine components of the pancreas during the development of pancreatic ductal adenocarcinoma (PDAC), highlighting that the role of endocrine cells in this process has not been thoroughly explored.
- Using advanced techniques like single-cell and spatial transcriptome sequencing, researchers discovered significant changes in pancreatic endocrine cells, particularly an increase in pancreatic polypeptide-positive cells, as cancer progresses.
- The findings suggest a mechanism where PDAC cells can induce the transformation of pancreatic α and β cells into dual-function cells, which may contribute to cancer development, indicating a complex interplay between endocrine and exocrine cells in the tumor microenvironment.
The pre-metastatic microenvironment consists of pro-metastatic and anti-metastatic immune cells in the early stages of cancer, when the primary tumor begins to proliferate. Redundantly, pro-inflammatory immune cells predominated during tumor growth. Although it is well known that pre-metastatic innate immune cells and immune cells fighting primary tumor cells become exhausted, the mechanism by which this occurs is unknown.
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