Publications by authors named "Chenxuan Yan"
Objective: We improved the developmental capacity of porcine early embryos via supplementation with fisetin during in vitro culture (IVC). In addition, we investigated the antioxidant mechanism of fisetin via activation of the NRF2-ARE signalling pathway in porcine early embryos.
Methods: Fisetin (0, 1, 2.
Article Synopsis
- This study explored the effects of oleanolic acid (OA) on porcine oocyte maturation during in vitro conditions, highlighting its antioxidant and anti-inflammatory properties.
- Supplementing with 5 μM OA led to higher rates of mature oocytes and successfully activated embryos, showing improvements in cellular functions and development metrics.
- The mechanisms suggest that OA enhances antioxidant capacity and promotes maturation by activating the Nrf2/HO-1 signaling pathway, which increases protective gene expression and reduces oxidative stress in porcine oocytes.