Publications by authors named "Chenxu Li"
Article Synopsis
- Optothermal manipulation technologies use light-based temperature gradients to trap and move microparticles, demonstrating potential applications in various fields.
- The study explores the optical force of an annular beam on a reflective surface and finds that it cannot effectively trap particles in that scenario.
- By shaping a Gaussian beam with axicons, researchers generate an annular beam that heats a gold film, creating a successful optothermal trap that binds particles with significant trapping stiffness measured at 8.1 ± 2.9 fN/μm at 100 mW laser power.
Article Synopsis
- - Post-traumatic epilepsy (PTE) is a serious complication following traumatic brain injury (TBI) that increases health risks and mortality rates; researchers within the EpiBioS4Rx study aim to find therapies to prevent PTE in rat models.
- - The study focuses on sodium selenate, which has shown promise in reducing seizure development post-TBI by acting on specific proteins in the brain; experiments measure how the drug is processed in rats' bodies and its effectiveness in reaching the brain.
- - Results indicate that sodium selenate undergoes rapid transformation in the body and demonstrates complex clearance and distribution patterns, suggesting it effectively crosses the blood-brain barrier, which is crucial for its potential as a therapeutic agent.
Article Synopsis
- The research focuses on creating environmentally friendly films by incorporating lignin nanospheres (LNPs) made from recovered lignin into polyvinyl alcohol (PVA) solution.
- Results indicate that films with higher LNP content have improved UV blocking, antioxidant properties, and hydrophobicity, especially when lignin undergoes DES-THF pretreatment.
- Ultimately, the study concludes that the PVA/LNPs composite films exhibit advantageous mechanical, thermal, and functional properties, making them suitable for packaging applications.
Article Synopsis
- This study explores how miR-29 affects lipid metabolism in dairy cows by categorizing 32 cows into groups based on liver triglyceride content: healthy, mild fatty liver, and moderate fatty liver.
- Dairy cows with moderate fatty liver exhibited increased lipid buildup and elevated liver enzyme levels, while healthy calves had isolated hepatocytes tested with sodium oleate under different conditions.
- The results indicated that inhibiting miR-29 reduced lipid accumulation and liver enzyme levels, suggesting that miR-29 could be integral to understanding fatty liver disease in dairy cows.
Article Synopsis
- - YO is a sustainable photocatalyst with potential applications but struggles with visible light activation, limiting its effectiveness in practical scenarios.
- - Researchers paired YO with the narrow bandgap semiconductor AgI to create a Z-scheme heterostructure, enhancing photocatalytic activity by increasing oxygen vacancies and promoting better electron and energy transfer.
- - The combination significantly improves the degradation rates of pollutants like RhB and o-nitrophenol, showcasing the Z-scheme's capacity to enhance photocatalytic performance and offering insights for effective sewage purification solutions.
Article Synopsis
- The study evaluated the impact of supplemental polysaccharide (GCP) on the growth and intestinal health of weaned piglets over 28 days.
- Piglets were divided into three groups: a control group and two groups receiving different amounts of GCP (500 mg/kg and 1000 mg/kg).
- Results showed that the 1000 mg/kg GCP group had better growth performance, improved digestive enzyme activity, enhanced intestinal barrier function, and a more favorable microbial community compared to the control group.
Article Synopsis
- * Researchers created a gene knockout strain (RHΔ) to study the role of the HAD2a gene, finding that it is crucial for the parasite's replication and virulence.
- * Vaccination with the RHΔ strain showed promising results in mice, providing partial to strong protection against various strains of the disease, indicating its potential as a candidate for developing more effective vaccines.
Article Synopsis
- - The study investigates the spectral properties and refractive index (RI) sensitivities of helical intermedium-period fiber gratings (HIPFGs) in the low RI region, specifically focusing on gratings with periods ranging from 10-48 μm.
- - An optimized HIPFG structure achieved a high sensitivity of 302.5 nm/RIU within the RI range of 1.3 to 1.33, significantly outperforming traditional long-period fiber gratings.
- - The enhanced HIPFG was successfully utilized for breath monitoring, distinguishing various breathing states with a rapid response time of 10 ms, indicating its potential for medical applications.
The aim of the present study was to investigate the activity of AMPK and mTORC1 as well as TFEB transcriptional activity and autophagy-lysosomal function in the liver of dairy cows with mild fatty liver (FL) and cows with moderate FL. Liver and blood samples were collected from healthy dairy cows (n = 10; hepatic triglyceride content <1% wet weight) and cows with mild FL (n = 10; 1% ≤ hepatic triglyceride content < 5% wet weight) or moderate FL (n = 10; 5% ≤ hepatic triglyceride content < 10% wet weight) that had a similar number of lactations (median = 3, range = 2-4) and days in milk (median = 6 d, range = 3-9). Blood parameters were determined using a Hitachi 3130 autoanalyzer with commercially available kits.
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- This study examined how maternal gestational diabetes (GDM) and selenium deficiency affect the growth and glucose metabolism of offspring using female C57BL/6J mice.
- The research found that GDM led to increased obesity risk and abnormal glucose metabolism in female offspring, with different effects observed in males over time.
- Results indicated that oxidative stress and the PI3K/Akt signaling pathway played key roles in these effects, highlighting the importance of gender differences in the outcomes.
Article Synopsis
- Cr(VI) is a toxic pollutant that poses serious risks to all organisms, and current methods to eliminate it are costly and energy-intensive; hence, bioremediation offers a more sustainable alternative.
- Researchers discovered a new strain, Microbacterium sp. NEAU-W11, which effectively reduces Cr(VI) under various conditions and can tolerate other metal pollutants while being enhanced by certain metals and sugars.
- The study revealed that the reduction of Cr(VI) is not due to biological sorption, but biological reduction, with key enzymes located in the cell cytoplasm and resulting in Cr(III)-ligand complexes bound to extracellular substances, providing new insights into chromium degradation mechanisms.
Article Synopsis
- Dynamic positron emission tomography (PET) is crucial for assessing physiological changes, but reconstructing images from dynamic data is difficult due to low data counts in brief time frames.
- Recent advancements in model-based deep learning have improved low-count PET image reconstruction by enhancing spatial correlations but often overlook temporal factors.
- The proposed spatio-temporal primal dual network (STPDnet) effectively captures both spatial and temporal relationships using 3D convolutions, shows significant noise reduction in PET reconstructions, and outperforms existing methods in challenging low-count scenarios.
Analysis of the efficacy of percutaneous spinal endoscopic surgery in the treatment of lumbar spinal stenosis.
Minerva Gastroenterol (Torino)
December 2023
Article Synopsis
- - The direct seeding technology for rice is seen as a better alternative to traditional transplanting due to its benefits in saving labor and water, but chill stress hampers seed germination and seedling growth in Heilongjiang Province, China.
- - Researchers discovered that guvermectin (GV), a natural plant growth regulator, significantly improves rice seed germination and growth under low temperatures, resulting in increased emergence rates and overall yield.
- - The positive effects of GV were linked to enhanced enzyme activity and nutrient content, which help the seedlings better cope with chilling stress, suggesting its potential for improving direct-seeded rice performance in cold conditions.
Article Synopsis
- Senescence is when cells stop dividing due to various factors, leading to age-related diseases like neurodegenerative disorders, heart problems, and cancers.
- MicroRNAs (miRNAs) are small RNA molecules that help regulate gene expression and significantly influence the aging process across different species.
- The review explores the current understanding of miRNAs in aging and discusses their potential in diagnosing and treating diseases associated with aging.
Article Synopsis
- * Various evaluation methods, including traditional human taste tests and electronic tongue assessments, along with techniques like DSC and XRD, led to insights into the mechanism behind AK's taste-masking properties.
- * The results show that AK not only masks BH's bitterness by reducing its interaction with taste receptors but also forms a complex with BH that contributes to this effect.
Article Synopsis
- Up-conversion luminescence is a process where materials emit high-energy light when excited with longer wavelengths, with lanthanide-doped nanoparticles (Ln-UCNPs) being significant in biomedicine due to their beneficial properties.
- The review covers various synthesis methods for Ln-UCNPs and outlines four strategies to enhance their luminescence.
- Applications in phototherapy, bioimaging, and biosensing are discussed, along with challenges and future prospects for these nanoparticles.
Article Synopsis
- A study was conducted in Shanxi Province, China, to investigate the prevalence and risk factors of Chlamydia and Chlamydia abortus infections in cattle, analyzing 981 serum samples from 40 farms.
- The seroprevalence rates found were 52.29% for Chlamydia and 2.96% for C. abortus, with location identified as a significant risk factor for infection.
- The research revealed that larger animal farming operations had a higher seroprevalence of Chlamydia compared to household farms, providing important data for monitoring cattle health and potential zoonotic risks.
Article Synopsis
- The study examined the impact of Glycyrrhiza polysaccharide (GCP) on the growth, appetite, and inflammation in one-day-old male AA broilers over a 42-day period.
- Broilers fed diets with GCP showed improved Average Daily Feed Intake (ADFI) and Average Daily Gain (ADG), along with changes in hypothalamic mRNA levels related to appetite and inflammation.
- Supplementation with 600 mg/kg GCP yielded the best results, indicating its potential as a beneficial feed additive in poultry production.
Article Synopsis
- Systemic lupus erythematosus (SLE) presents complex challenges for diagnosis and treatment due to its multi-system involvement and heterogeneity; this study aims to investigate the genetic factors contributing to SLE's pathogenesis.
- Through high throughput sequencing of peripheral blood mononuclear cells (PBMCs) from SLE patients, researchers identified 2,495 differential genes, with specific pathways linked to cell cycle processes and responses to stress being notably upregulated.
- The study highlights the role of the CDC6 gene, which shows significant alternative splicing and is associated with increased cell proliferation in SLE patients, suggesting it may be a key player in the disease’s severity and progression.
Article Synopsis
- * A systematic review analyzed six randomized controlled trials, finding that CBT significantly reduced pain catastrophizing immediately after treatment, but not in follow-ups at three or twelve months.
- * The study concluded that more extensive research with longer follow-ups and larger participant samples is needed to fully understand the impact of CBT on pain and knee function post-TKA.
Article Synopsis
- An obligate intracellular bacterium causes chlamydiosis, affecting humans and animals globally, and significantly impacting the sheep industry economically.
- A study in Shanxi Province, northern China, collected 984 sheep serum samples to assess the prevalence of antibodies against this bacterium.
- Results revealed that 35.67% of samples were positive for the disease, with seroprevalence varying by region, while 7.93% tested positive for another related infection, marking the first report of their prevalence in sheep in that area.
Article Synopsis
- Lupus nephritis (LN) is a major complication in patients with systemic lupus erythematosus (SLE), and existing treatments often have undesirable side effects.
- SB431542, a targeted inhibitor of the TGFβ/Activin/NODAL pathway, showed promising results by improving clinical outcomes and reducing harmful biomarkers in NZB/W mice with LN.
- The treatment led to significant changes in gene expression related to B cell functions, signaling pathways, and inflammation, suggesting SB431542's potential for future clinical applications in managing LN.