A self-powered vibration sensor for downhole drilling tools based on hybrid electromagnetic-triboelectric nanogenerator.

The vibration of downhole drilling tools is important to the drilling process, which needs to be measured in real time. Here, a self-powered vibration sensor for downhole drilling tools based on a hybrid electromagnetic-triboelectric nanogenerator is proposed in this research. The sensor has high reliability because the triboelectric nanogenerator (TENG) and the electromagnetic generator (EMG) parts of the sensor can be used as vibration sensors alone, and it may also supply power to other micro-power measurements while drilling instruments when the TENG and the EMG are used in parallel to increase the output power.

Development of self-powered bubble velocity sensor for gas-liquid two-phase flow based on triboelectric nanogenerator.

Bubble velocity of gas-liquid two-phase flow in coalbed methane well is an key parameter for formulating coalbed methane drainage technology. In this paper, a self-powered bubble velocity sensor (GLT-TENG) of two-phase flow, which is composed of distributed copper electrodes and low-density polyethylene wrapped in an outer layer, is proposed and analyzed based on triboelectric nanogenerator. Test results show that the measurement range is 0-0.

Tanshinone II A improves the chemosensitivity of breast cancer cells to doxorubicin by inhibiting β-catenin nuclear translocation.

Numerous evidence link aberrant nuclear β-catenin accumulation to the development of breast cancer resistance, therefore, targeted inhibition of β-catenin nuclear translocation may effectively improve the chemosensitivity of breast cancer. Doxorubicin (Dox) is the most commonly used chemotherapeutic drug for breast cancer. Here, we determined that tanshinone II A (Tan II A) could improve the sensitivity of Dox-resistant breast cancer MCF-7/dox cells to Dox, and evaluated whether the sensitization effect of Tan II A on Dox was targeted to inhibit β-catenin nuclear translocation.

Tanshinone IIA promotes cardiac differentiation and improves cell motility by modulating the Wnt/β‑catenin signaling pathway.

Although the cardiovascular pharmacological actions of Tanshinone IIA (TanIIA) have been extensively studied, research on its roles in cardiac regeneration is still insufficient. The present study employed the cardiac myoblast cell line H9c2 to evaluate the possible roles of TanIIA in cardiac regeneration. It was found that certain concentration of TanIIA inhibited cell proliferation by suppressing the expression of proteins related to the cell cycle [cyclin dependent kinase (CDK)4, CDK6 and cyclin D1] and proliferation [c‑Myc, octamer‑binding transcription factor 4 (Oct4) and proliferating cell nuclear antigen (PCNA)] without inducing apoptosis.

Research on the Potential of Spherical Triboelectric Nanogenerator for Collecting Vibration Energy and Measuring Vibration.

The traditional downhole drilling vibration measurement methods which use cable or battery as power supplies increase the drilling costs and reduce the drilling efficiency. This paper proposes a spherical triboelectric nanogenerator, which shows the potential to collect the downhole vibration energy and measure the vibration frequency in a self-powered model. The power generation tests show that the output signal amplitude of the spherical triboelectric nanogenerator increases as the vibration frequency increases, and it can reach a maximum output voltage of 70 V, a maximum current of 3.

Development of gas-liquid two-phase flow pattern sensor of coalbed methane based on the principle of triboelectric nanogenerator.

During the mining of coalbed methane (CBM), real-time measurement conducted by a gas-liquid two-phase flow pattern sensor is one of the key steps in the development of a reasonable discharge and mining system. In this study, a self-powered flow pattern sensor based on the triboelectric nanogenerator (TENG) was proposed and analyzed. The basic principle is as follows: when the sensor is impacted by the bubbles of the two-phase flow, triboelectric charges are generated due to the contact between the copper electrode, which plays the dual roles of electrode and positive triboelectric material, and the PTFE which acts as negative triboelectric material.

Self-Powered Speed Sensor for Turbodrills Based on Triboelectric Nanogenerator.

Turbodrills play an important role in underground energy mining. The downhole rotational speed of turbodrills is one of the key parameters for controlling the drilling technology. Therefore, it is necessary to measure the rotational speed of the turbodrills in real time.

Combination of tanshinone IIA and doxorubicin possesses synergism and attenuation effects on doxorubicin in the treatment of breast cancer.

Doxorubicin (Dox) is a first-line drug for breast cancer chemotherapy. However, with the prolongation of chemotherapy cycle, breast cancer cells are increasingly tempt to resist Dox, and meanwhile, high cumulative dose of Dox brings enhancing toxic side effects, and these effects may lead to chemotherapy failure. Hence, it is necessary to search an agent in combination medication with Dox, which can not only enhance the chemosensitivity of Dox but also reduce the toxic side effects.