Adult animals are unable to regenerate heart cells due to postnatal cardiomyocyte cycle arrest, leading to higher mortality rates in cardiomyopathy. However, reprogramming of energy metabolism in cardiomyocytes provides a new perspective on the contribution of glycolysis to repair, regeneration, and fibrosis after cardiac injury. Pyruvate kinase (PK) is a key enzyme in the glycolysis process.
View Article and Find Full Text PDFRequirements for wide field of view (FOV) imaging system reflect the need for both uniform illumination as well as excellent image quality across the entire FOV. As the monocentric lens combined with a parallel array of relay imagers achieves a wide-FOV while maintaining a high resolution, we studied the monocentric cascade imaging system (MCIS). However, the imaging experiment of the prototype shows two issues, including vignetting and non-uniform image quality over the full FOV.
View Article and Find Full Text PDFAim: To evaluate the cost-utility of gefitinib and afatinib as first-line EGFR-mutated non-small-cell lung cancer treatments from the Chinese healthcare system perspective.
Materials & Methods: A Markov model was established, state transition probabilities were extracted from the LUX-Lung7 trial and utility values were from previous studies. The cost was extracted from local charge or relevant literature.