Association between ambient temperature and increased total length of hospital stay of patients with cardiopulmonary disease in Hong Kong.

Background: While temperature extremes have been shown to be associated with an increased risk of hospital admissions, evidence of their impact on the length of hospital stay, which may capture the lingering effects of temperature extremes, is scarce.

Objectives: We aimed to evaluate the association between daily variation in ambient temperature and daily variation in daily total length of stay (daily TLOS), a composite measure encompassing the daily count of hospital admissions and their corresponding length of hospital stay among cardiopulmonary patients. Additionally, we quantified the burden of TLOS attributable to non-optimal temperatures among Hong Kong's older adult population.

The role of Immune cells in Alzheimer's disease: a bidirectional Mendelian randomization study.

Background: Alzheimer's disease (AD) is a leading cause of dementia, characterized by the accumulation of amyloid-beta (Aβ) and hyperphosphorylated tau proteins, leading to neuroinflammation and neuronal damage. The role of the immune system in AD pathogenesis is increasingly recognized, prompting an exploration of the causal relationship between immune cells and AD by using Mendelian randomization (MR) approaches.

Methods: Utilizing genome-wide association study (GWAS) data from European cohorts, we conducted an MR study to investigate the causal links between immune cell phenotypes and AD.