BMSC-derived exosomes improve rheumatoid arthritis by regulating Th17 cell differentiation through targeting PRDM1.

Background: Rheumatoid arthritis (RA) is categorized as an autoimmune condition. Bone marrow-derived mesenchymal stromal cell (BMSC) derived exosome (BMSC-Exo) exert vital character in RA. We aimed to investigate the regulatory mechanism of BMSC-Exo in alleviating RA.

Interruptions and downtime of continuous renal replacement therapy in critically ill adults: A retrospective observational study.

Background: The effective treatment time of continuous renal replacement therapy (CRRT) is significantly important. Downtime caused by interruptions is still unclear during a circuit filter.

Aim: This study aimed to analyse the interruptions and downtime during a circuit filter through the data recorded by the internal data storage cards of the CRRT machine.

Nonmetallic High-Entropy-Engineered Nanocarbons for Advanced ORR Electrocatalysis.

High-entropy materials are poised to revolutionize materials science and industrial applications due to their design flexibility, peculiar performance, and broad applicability. In this study, we present a proof-of-concept high-entropy engineered nanocarbon (HENC) co-doped with five nonmetal elements (B, F, P, S, and N), synthesized via in situ polymerization modification of ZIF-8 followed by pyrolysis. The HENC exhibits outstanding performance as a nonmetal electrocatalyst for the oxygen reduction reaction (ORR), with activity on par with benchmark Pt/C electrocatalysts and superior cyclic stability.

Effects of dietary fiber on the quality of fried oysters and oil Permeation mechanism.

Fried oysters are a traditional dish in coastal regions; however, concerns have been raised regarding the potential nutritional loss drawbacks due to the high temperatures in the frying process, which can lead to oil oxidation. This study investigates the effects of soybean dietary fiber (SDF) and citrus dietary fiber (CDF) at supplemental levels of 0.5 %, 1 %, 2 %, and 4 % on the overall quality of fried oysters.

Tracing the geographical origin of Chinese green tea based on fluorescent sensor array combined with multi-way chemometrics analyses.

Fluorescent sensor arrays are becoming a hot topic in many fields because they can simultaneously detect multiple targets in complex research systems. However, most researches have only collected two-dimensional fluorescence spectral data from fluorescent sensor array interacting with target analytes. In contrast, three-dimensional fluorescence spectra can provide richer information than two-dimensional fluorescence spectra.

Association Between Hypoxia-Inducible Factor-1α and Neurological Diseases: A Bidirectional Two-Sample Mendelian Randomization Analysis.

Background: Previous studies have suggested that hypoxia-inducible factor 1-α (HIF-1α) exerted multiple effects on different central nervous system disorders. However, it is still uncertain whether plasma HIF-1α can be a causal indicator for the relevant diseases. This study aimed to test the causality relationship between plasma HIF-1α and neurological diseases, including cerebrovascular diseases, migraines, and neurodegenerative diseases with a Mendelian randomization (MR) method.

Virome specific to tick genus with distinct ecogeographical distribution.

Background: The emergence of tick-borne pathogens poses a serious threat to both human and animal health. There remains controversy about virome diversity in relation to tick genus and ecogeographical factors.

Results: We conducted the meta‑transcriptomic sequencing of 155 pools of ticks encompassing 7 species of 3 genera collected from diverse geographical fauna of Ningxia Province, China.

Association between liver fibrosis's noninvasive scores and retinal imaging changes: insights from NHANES.

Background: There is a known association between liver disease and retinopathy. However, the relationship between non-invasive fibrosis scores and retinal image changes remains unknown. The research sought to explore the link between Fibrosis-4 score (FIB-4) and Fibrosis-8 score (FIB-8) and retinal image changes.

Short- and long-term comparative effectiveness of nirmatrelvir/ritonavir and molnupiravir in asthma patients: a cohort study.

Background: Few studies evaluated the effectiveness of COVID-19 antivirals specifically in the asthma population This study assessed short- and long-term effects of nirmatrelvir/ritonavir versus molnupiravir in asthma population.

Methods: This is a retrospective cohort study on adult asthma patients infected with COVID-19, using real-world data obtained from the health officials in Hong Kong. Key inclusion criteria were infection with COVID-19 between March 16, 2022, and Oct 30, 2023, age ≥ 18 years, previous asthma diagnosis, and prescription history of an asthma medication.

A novel revision technique in the treatment for postoperative deviation after radial polydactyly reconstruction.

Purpose: Postoperative deviation (PD) is a complicated and troublesome complication after polydactyly reconstruction. We aim to investigate the clinical efficacy of a novel revision surgery, reconstruction of the balance of bone and soft tissue, treating PD after radial polydactyly reconstruction in comparison with a previous surgical plan.

Methods: We reconstructed the balance of bone and soft tissue to correct PD and the asymmetrical appearance of the thumb.

Intra- and peri-tumoral radiomics based on dynamic contrast-enhanced MRI for prediction of benign disease in BI-RADS 4 breast lesions: a multicentre study.

Background And Purpose: The study aimed to create a radiomics model based on breast intra- and peri-tumoral regions in dynamic contrast-enhanced (DCE) MRI to distinguish benign from malignant breast lesions of Breast Imaging Reporting and Data System (BI-RADS) 4.

Materials And Methods: A total of 516 patients from Hospital 1 were assigned to the training cohort. Then, 146 and 52 patients were enrolled from Hospital 2 and 3, respectively, as the internal and external test cohort.

Efficacy and conversion outcome of chemotherapy combined with PD-1 inhibitor for patients with unresectable or recurrent gallbladder carcinoma: a real-world exploratory study.

Background: Gallbladder carcinoma (GBC) is an extremely aggressive tumor of the biliary tract with a bleak prognosis, and the evidence supporting the benefit of available systemic therapy for advanced GBC is scarce. Herein, this study intended to investigate the real-world outcome of chemotherapy combined with programmed death-1 (PD-1) inhibitor for the management of unresectable or recurrent GBC.

Methods: From January 2018 to December 2023, consecutive patients who were treated with systematic treatment, including chemotherapy or the combination of chemotherapy plus PD-1 inhibitor, for unresectable or recurrent GBC were retrospectively identified.

A discrete-time split-state framework for multi-state modeling with application to describing the course of heart disease.

In chronic disease epidemiology, the investigation of disease etiology has largely focused on an endpoint, while the course of chronic disease is understudied, representing a knowledge gap. Multi-state models can be used to describe the course of chronic disease, such as Markov models which assume that the future state depends only on the present state, and semi-Markov models which allow transition rates to depend on the duration in the current state. However, these models are unsuitable for chronic diseases that are largely non-memoryless.

Development and validation of a nomogram for arthritis: a cross-sectional study based on the NHANES.

Previous epidemiological studies have associated various body-related indicators with arthritis; however, the results have been inconclusive. Therefore, this research aimed to develop and validate a nomogram model for predicting the risk of arthritis using easily available indicators and to assess the model's predictive performance. Cross-sectional data were collected from 3660 participants in the 2021-2023 National Health and Nutrition Examination Survey.

Post-Thrombectomy Mild Hypercapnia State Prevents Poor Outcome by Reducing Infarct Progression.

Objective: In endovascular therapy (EVT) for stroke, futile recanalization contributes to poor prognosis. Mild hypercapnia may enhance cerebral blood flow and prevent ischemia, but its impact on prognosis in successfully recanalized EVT patients is unclear.

Methods: We retrospectively analyzed 237 patients from the INSPIRE database who underwent successful recanalization at our center (October 2018-March 2022).

FGF21, a modulator of astrocyte reactivity, protects against ischemic brain injury through anti-inflammatory and neurotrophic pathways.

Ischemic stroke is a frequent cause of mortality and disability, and astrocyte reactivity is closely associated with injury outcomes. Fibroblast growth factor 21 (FGF21), an endogenous regulator, has been shown to perform pleiotropic functions in central nervous system (CNS) disorders. However, studies on neurological diseases have paid little attention to the effects and detailed mechanisms of FGF21 in astrocytes.

Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy.

Sepsis-induced skeletal muscle atrophy is common in septic patients with the increases risk of mortality and is associated with myocellular mitochondrial dysfunction. Nevertheless, the specific mechanism of sepsis muscle atrophy remains unclear. Here we conducted a clinical retrospective analysis and observed the elevation of skeletal muscle index (ΔSMI) was an independent risk factor for 60-day mortality in septic patients.

Observation of metal-organic interphase in Cu-based electrochemical CO-to-ethanol conversion.

Interphases are critical in electrochemical systems, influencing performance by controlling ion transport and stability. This study explores a metal-organic interphase in the electrocatalytic reduction of CO (CORR) on Cu, extending the concept of interphases to CO conversion. Investigating organic modifications on CuO, we discover metal-organic interphases over 10 nm thick in highly ethanol-selective systems, contrary to the expected monolayer adsorption.

Fine mapping of stripe rust resistance gene YrAn1589 in common wheat using Wheat660K SNP array and BSR-Seq.

A new stripe rust resistance gene YrAn1589 in Chinese wheat Annong1589 was mapped to a 160.9-166.6 kb interval on chromosome arm 3BL and co-segregated with a marker CAPS9 developed from candidate gene TraesCS3B03G1054600.

Synthesis and Biological Evaluation of Novel Triazine Analogs as Rad6 Inhibitors.

Unlabelled: Rad6 is an E2 ubiquitin-conjugating enzyme that plays critical roles in genome maintenance and proteostasis. Rad6 is frequently overexpressed in many cancers and promotes cancer development, progression, and chemotherapy resistance.

Purpose: Given its role in cancer development and progression, Rad6 is an underexplored therapeutic target.

Comparing two autologous bone grafting techniques to treat clavicular midshaft atrophic nonunion: a retrospective study.

Background: Open reduction, superior plate (SP) fixation, and autologous cancellous granular bone grafting (ACGBG) are common strategies for treating clavicular midshaft atrophic nonunion (CMAN). We aimed to compare the radiological findings and clinical effects of two autologous cancellous bone grafts (ACBGs) and those of single SP fixation, to treat CMAN.

Methods: This retrospective study comprised 62 patients admitted to our hospital with CMAN (ACGBG with single SP fixation between March 2012 and October 2017, 32 patients; autologous cancellous structured bone grafting [ACSBG] with single SP fixation between November 2017 and May 2021, 30 patients).

Polymer-Scaffold Induced Extensive Hydrogen-Bond Network: Enabling High Transport of Proton and Oxygen in Cathode Catalyst/Ionomer Interfaces.

Uneven ionomer coverage in the cathode catalyst layer of proton exchange membrane fuel cells (PEMFCs) impedes proton conduction and oxygen diffusion, particularly at low platinum loadings. Here, a functionalized polymer-scaffold is designed and constructed by using hydroxy-pyridine polybenzimidazole (PyOHPBI) with abundant hydrogen-bond sites, thereby proposing a hydrogen-bond synergistic strategy to address the challenges of optimizing ionomer distribution and enhancing the transport of protons and gas through the catalyst layer. By integrating molecular dynamics simulations, in situ and ex-situ characterization methods, the design achieves 144.

Solar evaporator coupled with strong/weak convection and its cascade utilization.

Modulating the macro/nanoarchitecture of evaporators to effectively harness diverse renewable energy sources is of paramount importance for optimizing the performance of solar-driven interfacial evaporation. Inspired by the geometric structure of a windmill, we designed an innovative solar evaporator that expertly harnesses both strong and weak convection. During the purification of heavy metal wastewater, the maximum evaporation rate can reach 4.