Benefit of adjuvant chemotherapy for T1cN0M0 and selected T1bN0M0 triple-negative breast cancer: a nationwide cancer registry-based study.

Background: The efficacy of adjuvant chemotherapy for T1N0M0 triple-negative breast cancer (TNBC) has not been clearly elucidated. Thus, we aimed to evaluate the efficacy of adjuvant chemotherapy for patients with T1a-cN0M0 TNBC.

Patients And Methods: Patients newly diagnosed with TNBC between 2011 and 2015 were identified and followed up until the end of 2020 using the Taiwan Cancer Registry.

Lipidomic Analysis of Serum Lipid Profiles in Idiopathic Central Precocious Puberty and the Potential Regulatory Role of GnRHa in Lipid Metabolism.

Idiopathic central precocious puberty (ICPP) is an endocrine disorder increasingly observed in children, commonly treated with gonadotropin-releasing hormone agonists (GnRHa). However, the serum lipid profiles in girls with ICPP and the potential regulatory effects of GnRHa in lipid metabolism remain unclear. This research analyzed lipidomic profiles of serum samples from girls younger than 10 years of age, including 37 patients with ICPP, 32 ICPP patients treated with GnRHa, and 30 age-matched healthy controls.

Linkage Position-Controlled Synthesis of Diverse Zirconium Metal-Organic Frameworks with Prominent Intrinsic Proton Conductivities.

Herein, by engineering the geometries of the organic linkers, two pyrrolo-pyrrole-based low-symmetry tetracarboxylate linkers (TAPPs) were successfully designed and subsequently used for the construction of two new zirconium-based metal-organic frameworks (Zr-MOFs) ( and ). The reduction of the linker symmetry arises from both the asymmetric pyrrolo-pyrrole core and the integration of both the - and -benzoate coordination groups on the linkers. Both MOFs are composed of 8-connected Zr nodes and 4-connected highly deformed TAPP linkers with the same topology, but distinct linker arrangements can be observed in two structures.

Suspect Screening of Pharmaceuticals and Their Transformation Products (TPs) in Wastewater during COVID-19 Infection Peak: Identification of New TPs and Elevated Risks.

Pharmaceuticals and their transformation products (TPs) in wastewater are emerging contaminants that pose risks to ecosystems and human health. Here, a typical period marked by the easing of the "zero-COVID" policy in December 2022, resulting in unprecedented infections in China, was chosen to illustrate the environmental impact of pharmaceutical usage during the COVID-19 pandemic. A suspect screening workflow was developed to identify pharmaceuticals and transformation products (TPs) in wastewater influent and effluent from a wastewater treatment plant (WWTP) during the peak and postpeak periods of COVID-19, integrating medication recommendations and TPs' prediction.

Sulfur Bridge Geometry Boosts Selective Fe═O Generation for Efficient Fenton-Like Reactions.

High-valent iron-oxo species (Fe═O) is a fascinating enzymatic agent with excellent anti-interference abilities in various oxidation processes. However, selective and high-yield production of Fe═O remains challenging. Herein, Fe diatomic pairs are rationally fabricated with an assisted S bridge to tune their neighbor distances and increase their loading to 11.

A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing.

The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation of inflammation levels, and prevention of bacterial infections. Therefore, a multifunctional wound dressing with antioxidant, local glycocontrol, and antibacterial properties is developed to promote diabetic wound healing. This dressing is constructed by co-loading gold-cerium oxide (AuCeO) dumbbells and glucose oxidase (GOx) into a reactive oxygen species (ROS)-sensitive hydrogel matrix (ACG gels).

Engineering Extracellular Vesicles Derived from 3D Cultivation of BMSCs Enriched with HGF Ameliorate Sepsis-Induced Lung Epithelial Barrier Damage.

Sepsis is a critical condition with high mortality, often leading to acute lung injury (ALI) due to uncontrolled inflammatory responses and alveolar epithelial damage. Extracellular vesicles (EVs), particularly mesenchymal stem cell-derived EVs, have shown therapeutic potential in sepsis-related organ dysfunction by transferring RNAs and proteins. However, their clinical use is limited by low efficacy and yield.

Dietary specialization among individual squid: using as a case and meta-analysis for other squid species.

Squid, which occupy a similar role to teleost fish as open water predators, are opportunistic foragers. However, there is a lack of empirical evidence related to whether individual squid specialize their diets to optimize fitness. We investigated whether individual squid have specialized diets and what factors impact any specialization using the Argentine shortfin squid as a case study species, coupled with a meta-analysis for other squid species.

Synergistic metabolic modulation of fibroblast-like synoviocytes targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis.

Elevated glucose metabolism is a prominent characteristic of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). However, the efficacy of inhibiting a single target of glucose metabolism in FLS using small molecular inhibitors is limited for RA treatment. Herein, the synergistic inhibition of FLS' survival, proliferation, and activation by combining two glucose metabolism inhibitors, diclofenac (DC) and lonidamine (LND) was first verified.

Optimized lipid nanoparticles enable effective CRISPR/Cas9-mediated gene editing in dendritic cells for enhanced immunotherapy.

Immunotherapy has emerged as a revolutionary approach to treat immune-related diseases. Dendritic cells (DCs) play a pivotal role in orchestrating immune responses, making them an attractive target for immunotherapeutic interventions. Modulation of gene expression in DCs using genome editing techniques, such as the CRISPR-Cas system, is important for regulating DC functions.

Facilitation of mucosal healing by estrogen receptor in ulcerative colitis through suppression of branched-chain amino acid transport and subsequent triggering of autophagy in colonic epithelial cells.

Colonic mucosal healing is the ultimate goal of ulcerative colitis (UC) treatment, but it remains difficult to realize. Given the higher incidence of UC in males and the beneficial effect of estrogen on UC, we conducted this study to examine the therapeutic potential of estrogen receptor (ER), the primary ER subtype in colon, on mucosal healing in UC. Our study is the first to report that ER activation degree was positively correlated with mucosal healing in patients with UC.

Rumen-protected guanidinoacetic acid improves growth performance in beef cattle under chronic heat stress by reshaping gut microbiota and modulating serum metabolism.

This study aimed to investigate the effects of rumen-protected guanidinoacetic acid (RP-GAA) on growth performance, gut microbiota, and serum metabolism in beef cattle under chronic heat stress. A randomized block design was employed to allocate 14 F1 Simmental crossbred cattle (Simmental ♂ ×  ♀) with an average body weight of 312.5 ± 55.

Spin is Prevalent in Abstracts of Systematic Reviews and Meta-analyses of Anterolateral Ligament Reconstruction and Lateral Extra-Articular Tenodesis.

Purpose: To analyze the incidence of spin in the abstracts of systematic reviews and meta-analyses investigating anterolateral ligament augmentation or lateral extra-articular tenodesis as treatment for anterior cruciate ligament injuries.

Method: Studies were identified using the Preferred Reporting Items for Systematic Reviews and Meta Analysis guidelines searching PubMed, Web of Science, and Scopus in November 2023. The abstracts were graded for the incidence of the 15 most common types of spin, and full texts were reviewed for AMSTAR 2 classification.

Cadaveric Specimens Used in Studies Evaluating Bone Loss in Anterior Shoulder Instability Are Not Representative of the Affected Patient Population: A Systematic Review.

Purpose: To examine the age, sex, and site of evaluated bone loss in specimens used in cadaveric studies assessing the role of bone loss in anterior shoulder instability and to evaluate whether these studies evaluate glenoid and humeral bone loss separately or as a combined biomechanical problem.

Methods: Embase, MEDLINE, Scopus, Web of Sciences, Google Scholar, and Cochrane databases were queried electronically in April 2023 for cadaveric studies examining the relationship between anatomic structures and recurrent anterior shoulder instability. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria.

Continuous Skin Rejuvenation by Combining Nonablative Fractional Laser With Daily Application of a Multibeneficial Composition Formulation: A Blinded Randomized Clinical Trial Study.

Background And Aims: Skin aging is a common concern among individuals, and laser treatments are recognized as one of the most effective approaches to mitigate the aging process. The study aims to compare a multibeneficial formula serum versus a blank formulation in achieving maximum efficacy following a single treatment of nonablative fractional laser for facial skin rejuvenation.

Methods: This study was a double-blind, split-face, monocentric, randomized clinical trial in China (September 24, 2023-March 07, 2024), and 37 patients seeking the Fotona 4D laser treatment for aging-related facial changes were enrolled.

Ganglioglioma in mature cystic teratoma of the ovary: Case report and review of the literature.

Introduction: Ganglioglioma of the ovary is a rare neuroectodermal-type tumor, morphologically like its counterparts in the central nervous system, and only two cases have been reported before.

Case Report: The patient, a 30-year-old woman with no prior medical history of brain tumors or neurological disorders, was found to have a cystic mass in the left ovary, accompanied by two mural nodules. Histologically, the mural nodule in the teratoma exhibited a combination of neoplastic ganglion and glial cells.

Canopy structural heterogeneity drives α and β species-genetic diversity correlations in a Chinese subtropical forest.

Patterns and drivers of species-genetic diversity correlations (SGDCs) have been broadly examined across taxa and ecosystems and greatly deepen our understanding of how biodiversity is maintained. However, few studies have examined the role of canopy structural heterogeneity, which is a defining feature of forests, in shaping SGDCs. Here, we determine what factors contribute to α- and β-species-genetic diversity correlations (i.

The incidence of hyperkalemia in patients with secondary hyperparathyroidism after ultrasound-guided radiofrequency ablation vs. parathyroidectomy.

Introduction: The aim of our study was to compare the incidence of hyperkalemia in maintenance dialysis patients with secondary hyperparathyroidism(SHPT) after parathyroidectomy(PTX) or ultrasound-guided radiofrequency ablation(RFA), and to explore the risk factors and the best preoperative serum potassium threshold.

Methods: We defined hyperkalemia as serum potassium >5.30 mmol/L.

Disseminated Infection and Hyperammonemic Encephalopathy in a Patient With Activated PI3K Delta Syndrome 2.

Hyperammonemia syndrome (HS) from infection is typically reported in posttransplant recipients, particularly lung transplant. We describe a young woman with activated PI3K delta syndrome 2 who presented with HS from disseminated infection with septic arthritis. We also performed a literature review of -associated HS in nontransplant patients.

Predictors of permanent pacemaker requirement in aortic stenosis patients undergoing self-expanding valve transcatheter aortic valve replacement using the cusp overlap technique.

Introduction: Since TAVR was approved for lower-risk aortic stenosis (AS) patients, managing post-implantation conduction disturbances has become crucial, especially with self-expanding heart valves (SEV). This study aims to identify risk factors for conduction disturbances in such patients using a specific fluoroscopic cusp overlap (COL) technique.

Methods: This retrospective study analyzed AS patients who underwent TAVR with SEV from 2019 to 2022, excluding those needing pacemakers or valve-in-valve procedures.

Endoscopy-assisted anterior cervical discectomy and fusion with internal fixation vs conventional surgery in the treatment of cervical disc herniation.

Introduction: Cervical disc herniation (CDH) is a common condition, usually caused by excessive strain or trauma to the spine. Initially, it is treated conservatively; however, complex and resistant cases may require a surgical intervention.

Aim: We aimed to compare the clinical effect of endoscopy-assisted anterior cervical discectomy and fusion (ACDF) with internal fixation and conventional surgery in the treatment of CDH.

Regulating the electrocatalytic active centers for accelerated proton transfer towards efficient CO reduction.

The electrochemical CO reduction reaction (CORR) is an important application that can considerably mitigate environmental and energy crises. However, the slow proton-coupled electron transfer process continues to limit overall catalytic performance. Fine-tuning the reaction microenvironment by accurately constructing the local structure of catalysts provides a novel approach to enhancing reaction kinetics.