Fluorescence intensity of parathyroid glands in thyroid and parathyroid surgery: a near-infrared autofluorescence study.

Objective: Near-infrared autofluorescence (NIRAF) imaging shows promise in identifying parathyroid gland (PG) during surgery. However, the clinical application of NIRAF faces challenges due to the heterogeneous fluorescence intensity (FI) of PGs observed in different thyroid and parathyroid diseases. This study aimed to evaluate the effectiveness of NIRAF in PG detection and to analyze the FI of PGs in patients with various thyroid and parathyroid diseases.

Estimating the Number of Primary vs Incidental COVID-19 Hospitalizations in Santa Clara County.

Background: The goal of this study was to evaluate whether International Classification of Diseases, 10th Revision (ICD-10), discharge data can be used to accurately differentiate primary coronavirus disease 2019 (COVID-19) hospitalizations, which are specifically due to COVID-19, from incidental COVID-19 hospitalizations for monitoring COVID-19 trends in a large county health department. We sought to explore the use of machine learning algorithms for enhancing surveillance capabilities in a local public health setting.

Methods: Discharge data for 5122 Santa Clara County hospitalizations with a positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction or antigen test occurring between December 15, 2021, and August 15, 2022, were used to train a series of models for classifying primary COVID-19 hospitalizations using chart review as a gold standard.

Perioperative comparison of whether the liver was lifted out of the abdominal cavity in Kasai surgery.

Objective: To compare the perioperative effect of whether the liver is lifted out of the abdominal cavity during Kasai surgery in patients with biliary atresia type III.

Methods: We retrospectively analyzed 29 males and 33 females aged 2.2 ± 0.

A Case Report of Gilbert Syndrome Presenting With Acute Cholecystitis.

A 38-year-old male with Gilbert syndrome presented with acute cholecystitis, jaundice, and elevated liver enzymes. This case highlights the importance of genetic testing for unexplained jaundice, avoiding misdiagnosis, and guiding personalized treatment for Gilbert syndrome.

Identifying meteorological factors influencing catechin biosynthesis and optimizing cultivation conditions of tea plant ().

Catechins, the most important bioactive components in tea plants (), are influenced by the growth environment. To identify and optimize the key meteorological factors affecting catechin accumulation, we investigated the relationship between meteorological factors and tea plant catechin biosynthesis across three growing seasons at 10 locations. Rainfall, average temperature, and effective accumulated temperature (EAT) were identified as key drivers regulating catechin accumulation via the responsive expression of key structural genes , , and .

Comprehensive genome-wide analysis of the gene family of and functional validation of under different abiotic stresses.

Introduction: Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) is a key enzyme in the terpenoid biosynthetic pathway, playing a crucial role in plant stress responses. However, the gene family in , a traditional Chinese medicinal herb with high steroidal saponin content and strong stress tolerance, remains poorly understood. This study investigates the stress response mechanisms of the gene family in under abiotic stress conditions.

Effects of simulated litter inputs on ecological niches and interspecific connectivity of alpine meadow plants.

Introduction: Plant litter enters the soil as the main nutrient for alpine meadow ecosystems, and the amount of litter input has a significant effect on alpine meadow plant diversity, ecological niches, and interspecific connectivity.

Methods: The ecological niche width, ecological niche overlap and interspecific associations of alpine meadow species in the Sanjiangyuan area of the Qinghai-Tibetan Plateau were investigated using ecological statistical methods, and the competitive linkages between species and limited resources within the community and the stable coexistence among populations under different levels of plant litter inputs were explored.

Results: (1) Litter inputs could significantly increase the plant diversity and aboveground biomass of alpine meadows, and the species with the highest importance value was Clarke.

Identification of electric vehicle susceptible to thermal runaway based on risk accumulation.

Accurate fault diagnosis of power batteries is significant to ensure safe operation of electric vehicles. Most of existing methods rely heavily on real-time collection of battery status parameters, including voltage, current, and temperature, by the on-board battery management system to facilitate diagnosis. Nevertheless, these approaches suffer from inherent latency issues, lacking precision in risk predictions, and unable to accurately provide insights on vehicles that do not conform to the diagnostic criteria.

Optimizing the design of a pediatric blood pump through orthogonal experimentation.

Background: Pediatric heart failure patients weighing less than 30 kg are prioritized for small axial flow blood pumps due to their smaller body size. This study aims to optimize the blade design of pediatric axial flow blood pumps by conducting orthogonal experiments on blade parameters and integrating hydraulic experiments with hemodynamic numerical simulations, so as to improve the hydraulic performance of pediatric blood pumps while reducing blood damage.

Methods: This study employs a combination of computational fluid dynamics (CFD) and orthogonal experimentation to optimize six key parameters of the impeller blade.

Utilizing an adenosine triphosphate bioluminescence assay as an indicator of instrument and environmental cleanliness in the radiology department: a pilot study.

Background: Controlling healthcare-associated infections (HAIs) remains one of the major challenges faced by healthcare systems worldwide. Effective management of HAIs has become a critical indicator for evaluating the quality of services provided by medical institutions.

Aim: This study aims to compare the outcomes of environmental and instrument cleaning audits using an adenosine triphosphate (ATP) bioluminescence assay to prevent the spread of micro-organisms within medical environments.

How dispositional optimism-pessimism relates to early adolescents' emotional maladjustment during COVID-19? Moderating roles of knowledge about the disease and parent-child conflicts.

Introduction: The COVID-19 pandemic and associated containment measures changed the daily lives of children and adolescents around the world. To investigate the individual differences in emotional maladjustment under the COVID-19 pandemic, this study focused on the roles of dispositional optimism-pessimism, knowledge about the COVID-19 disease, and conflicts with parents among Chinese early adolescents.

Method: edge about the COVID-19 disease, and conflicts with parents among Chinese early adolescents.

Breaking new ground: machine learning enhances survival forecasts in hypercapnic respiratory failure.

Background: The prognostic prediction of patients with hypercapnic respiratory failure holds significant clinical value. The objective of this study was to develop and validate a predictive model for predicting survival in patients with hypercapnic respiratory failure.

Methods: The study enrolled a total of 697 patients with hypercapnic respiratory failure, including 565 patients from the First People's Hospital of Yancheng in the modeling group and 132 patients from the People's Hospital of Jiangsu Province in the external validation group.

The intestinal microbiota modulates the visceral sensitivity involved in IBS induced by restraint combined with tail clustering.

Objective: To compare three common stimuli that induce emotional stress to identify the optimal method for establishing an animal model that aligns with the clinical pathogenesis of irritable bowel syndrome (IBS) and to explore the gut microbiota mechanisms underlying IBS development.

Methods: Thirty-six SPF-grade female Kunming mice were randomly divided into four groups: the normal control (NC) group, the restraint stress (BM) group, the tail clamp stress (CTM) group, and the restraint combined with tail clamp stress (BCTM) group, with 9 mice in each group. The NC group was fed normally without any stimulation.

Carboplatin and vinblastine monthly in the optic pathway and hypothalamic gliomas: A retrospective analysis in a single institute.

Background: Chemotherapy plays an important role in the treatment of optic pathway hypothalamic gliomas (OPHGs). Commonly used regimens include carboplatin and vincristine and monotherapy with vinblastine weekly. In this retrospective study, we used a monthly regimen of carboplatin and vinblastine to treat progressive/recurrent OPHGs and evaluated their effectiveness, visual preservation, and toxicity.

Combined genomic, transcriptomic, and metabolomic analyses provide insights into the fruit development of bottle gourd ().

Bottle gourd ( (Molina) Standl) is a widely distributed Cucurbitaceae species, but gaps and low-quality assemblies have limited its genomic study. To address this, we assembled a nearly complete, high-quality genome of the bottle gourd (Pugua) using PacBio HiFi sequencing and Hi-C correction. The genome, being 298.

The lower rate of bone and joint infection in patients with open extremity fractures associated with vaccination prior to injury: a propensity-matched cohort study.

Background: Vaccines could strengthen the innate immune system in addition to conferring protection against their target pathogen via vaccine-induced immunomodulation, a phenomenon termed trained immunity. The purpose of the present study was to determine whether vaccination prior to injury is associated with a lower rate of bone and joint infections (BJIs) in patients with open extremity fractures.

Methods: Patients with open extremity fractures treated at one hospital between January 2010 and December 2019 were identified.

Person-Centered Preventive Health Care: Gathering Stakeholder Input on Evidence and Implementation.

Introduction: Clinical preventive services, such as screening tests, vaccinations, behavioral counseling, or preventive medication, are offered to most people on the basis of age, sex, health behaviors, or clinical risk factors, with goals of detecting early disease, preventing future disease, or mitigating the impact of unhealthy behaviors on future health. However, many people do not receive all the recommended services for which they are eligible.

Methods: The Agency for Healthcare Research and Quality identified 4 topics for gathering stakeholder input on evidence and implementation for the equitable delivery of clinical preventive services.

Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial.

Background: MP-AzeFlu (Dymista; Meda Pharma GmbH & Co., KG), a formulation combining azelastine hydrochloride and fluticasone propionate in a single spray, is superior to fluticasone propionate alone in relieving symptoms and improving the quality of life of patients with allergic rhinitis.

Objectives: In this study, we evaluated whether the effect of AzeFlu, a generic drug manufactured from China, is equivalent to that of MP-AzeFlu.

Self-Healable Hydrogel for Regression of Liver Fibrosis.

Liver fibrosis is considered as a wound healing process in the presence of chronic hepatic injury. A hydrogel (CPDP) based on chitosan-phenol that undergoes fast gelling and owns self-healing and injectable properties was investigated for the effect on regression of liver fibrosis. For the purpose, we established both in vitro and in vivo liver fibrosis models and implanted CPDP hydrogel into the injured liver.

Impact of healthy lifestyles on the risk of metabolic dysfunction-associated steatotic liver disease among adults with comorbid hypertension and diabetes: Novel insight from a largely middle-aged and elderly cohort in South China.

Aims: The association between lifestyle and metabolic dysfunction-associated steatotic liver disease (MASLD) has been well documented. However, evidence is still limited from vulnerable populations, especially middle-aged and elderly adults with comorbid hypertension and diabetes, who are at higher risk of developing MASLD than the general population. We aimed to examine the potential causal links of a healthy lifestyle with the risk of MASLD in this vulnerable population.

lncRNA1471 mediates tomato-ripening initiation by binding to the ASR transcription factor.

The regulatory mechanisms underlying fruit ripening, including hormone regulation, transcription factor activity, and epigenetic modifications, have been discussed extensively. Nonetheless, the role of long non-coding RNAs (lncRNAs) in fruit ripening remains unclear. Here, we identified lncRNA1471 as a negative regulator of tomato fruit-ripening initiation.

Surface Engineering Enabling Efficient Upcycling of Highly Degraded Layered Cathodes.

Direct recycling of cathode materials has attracted phenomenal attention due to its economic and eco-friendly advantages. However, existing direct recycling technologies are difficult to apply to highly degraded layered materials as the accumulation of thick rock-salt phases on their surfaces not only blocks lithiation channels but also is thermodynamically difficult to transform into layered phases. Here, a surface engineering-assisted direct upcycling strategy that reactivates the lithium diffusion channels at the highly degraded cathode surfaces using acid etching explored.

Difunctionalization of Alkenes toward 3,3-Disubstituted and Dihydrobenzoindolines by Using an Imidazolylidene Palladacyclic Catalyst.

The synthesis of valuable 2a,3-dihydrobenzo[]indolines was successfully achieved by combining IPr-Pd-Oxa-catalyzed cross-coupling and proton-induced hydroarylation in a one-pot method. In situ-generated alkynyl-functionalized 3,3-disubstituted indolines were proved as the key intermediate, bearing a broad scope of substrates with diverse functional groups and electronic properties.

Modulation of Hydrogen Desorption Capability of Ruthenium Nanoparticles via Electronic Metal-Support Interactions for Enhanced Hydrogen Production in Alkaline Seawater.

The development of efficient and stable electrocatalysts for the hydrogen evolution reaction (HER) is essential for the realization of effective hydrogen production via seawater electrolysis. Herein, the study has developed a simple method that combines electrospinning with subsequent thermal shock technology to effectively disperse ruthenium nanoparticles onto highly conductive titanium carbide nanofibers (Ru@TiC). The electronic metal-support interactions (EMSI) resulted from charge redistribution at the interface between the Ru nanoparticles and the TiC support can optimize hydrogen desorption kinetics of Ru sites and induce the hydrogen spillover phenomenon, thereby improving hydrogen evolution.

Sustainable Synthesis of Polyfluoro-Pyrimido [1,2-] Benzimidazole Derivatives Using a Tandem Strategy─Ultrasound and an Integrated Continuous Flow System.

We have developed a novel ultrasound technique that generates significant amounts of CF-substituted benzo[4,5] imidazo [1,2-]pyrimidine analogues from easily accessible starting materials in an ecologically friendly and efficient approach. This method is notably helpful for producing physiologically relevant compounds containing the imidazopyrimidine unit, which serves as a versatile building block for the synthesis of -fused heterocycles and is devoid of metals, solvents, additives, and catalysts. Additionally, utilizing ultrasound in an open-air environment, a range of polyfluoro-ynones were successfully reacted with 2-aminobenzimidazole, generating a diverse array of polyfluoroimidazo[1,2-]pyrimidine derivatives.