Integrative analysis of the ABC gene family in sorghum revealed SbABCB11 participating in translocation of cadmium from roots to shoots.

This study identified a SbABCB11 gene in sorghum that could enhance Cd translocation from roots to shoots, thus increasing Cd accumulation in shoots. Cadmium (Cd) is a widespread soil contaminant threatening human health. As an energy plant, sorghum (Sorghum bicolor (L.

Trps1 regulates mouse zygotic genome activation and preimplantation embryo development via the PDE4D/AKT/CREB signaling pathway.

Despite zygotic genome activation (ZGA) is crucial for early embryonic development, its regulatory mechanism is still unclear in mammals. In the present study, we demonstrate that TRPS1, a maternal factor, plays an essential role in mouse early embryogenesis by regulating the transition from 2-cell to 4-cell embryos during preimplantation development. The absence of Trps1 could leads to impaired ZGA through AKT/CREB signaling pathway.

Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood.

Childhood maltreatment is increasingly recognized as a pivotal risk factor for adverse health outcomes. However, comprehensive analyses of its long-term impact are scarce. This study aims to fill this gap by examining the genetic architectures of childhood maltreatment and its influence on adult health and socioeconomic outcomes.

Muskelin is a substrate adaptor of the highly regulated Drosophila embryonic CTLH E3 ligase.

The maternal-to-zygotic transition (MZT) is a conserved developmental process where the maternally-derived protein and mRNA cache is replaced with newly made zygotic gene products. We have previously shown that in Drosophila the deposited RNA-binding proteins ME31B, Cup, and Trailer Hitch are ubiquitylated by the CTLH E3 ligase and cleared. However, the organization and regulation of the CTLH complex remain poorly understood in flies because Drosophila lacks an identifiable substrate adaptor, and the mechanisms restricting the degradation of ME31B and its cofactors to the MZT are unknown.

Long-term outcomes of cryoballoon versus robotic magnetic navigation guided radiofrequency ablation in patients with persistent atrial fibrillation.

This study aimed to evaluate the long-term efficacy and clinical outcomes of catheter ablation performed with cryoballoon (CRYO) in comparison with robotic magnetic navigation (RMN) in patients with persistent atrial fibrillation (PersAF). A total of 200 patients with symptomatic PersAF were prospectively enrolled and non-randomly assigned (1:1) to the CRYO or RMN guided-ablation group undergoing pulmonary vein isolation (PVI) and additional linear ablation if necessary and then followed up over 5 years. The primary endpoint was freedom from atrial tachyarrhythmias (ATs) recurrence following a 3-month blanking period after the initial procedure.

A novel MRI contrast agent NaGdF@PEG-CLS@MMP-13 NPs for detecting articular cartilage injury.

Early detection of cartilage injuries is crucial due to their limited self-repair capacity and risk of joint dysfunction. Conventional contrast agents like gadolinium-diethylenetriamine-pentaacetic acid (Gd-DTPA) offer low specificity and T1 relaxivity (r1), limiting MRI application. This study introduces NaGdF nanoparticles (NPs) modified with polyethylene glycol (PEG) and cholesterol (CLS) to enhance hydrophilicity and lipophilicity.

Genome-wide KAS-Seq mapping of leukocytes in ischemia-reperfusion model reveals IL7R as a potential therapeutic target for ischemia-reperfusion injury.

Ischemia-reperfusion injury (IRI) is one of the leading causes of mortality and disability worldwide. Owing to its complex pathogenesis, there is still a lack of effective therapeutic targets in clinical practice, and exploring the mechanism and targets of IRI is still a major clinical challenge. This study aimed to explore the genetic alterations in leukocytes in peripheral blood after ischemia-reperfusion, aiming to discover new biomarkers and potential therapeutic targets.

Low lying excited states quantum entanglement and continuous quantum phase transitions.

From the perspective of entanglement in low-lying excited states, a profound analysis was carried out regarding the quantum phase transitions within three models that fall outside the Landau-Ginzburg-Wilson (LGW) paradigm. In the context of the deconfined quantum critical point (DQCP) in a one-dimensional quantum spin chain, our findings demonstrate a tight correlation between the reconstruction of low-lying excitation spectra and the DQCP. The precise location of the critical point and its continuous nature can be signaled by the singular behaviors of the entanglement of the first-excited state.

PPM1B degradation mediated by TRIM25 ubiquitination modulates cell cycle and promotes gastric cancer growth.

Protein phosphatase PPM1B, a member of the serine/threonine phosphatase family, has been implicated in various human cancers. In this study, our objective was to investigate the role of PPM1B in GC growth and explore the underlying mechanisms. Our findings revealed that PPM1B expression was downregulated in GC tissues, and higher levels of PPM1B expression were associated with improved overall survival in GC patients.

Heparan sulfate regulates myofibroblast heterogeneity and function to mediate niche homeostasis during alveolar morphogenesis.

Postnatal respiration requires bulk formation of alveoli that produces extensive surface area for gas diffusion from epithelium to the circulatory system. Alveolar morphogenesis initiates at late gestation or postnatal stage during mammalian development and is mediated by coordination among multiple cell types. Here we show that fibroblast-derived Heparan Sulfate Glycosaminoglycan (HS-GAG) is essential for maintaining a niche that supports alveolar formation by modulating both biophysical and biochemical cues.

Effectiveness and safety of the recombinant zoster vaccine in individuals ≥50 years of age with rheumatoid arthritis: a matched cohort and self-controlled case series study.

Objectives: In an interim analysis, we evaluated vaccine effectiveness (VE) against herpes zoster (HZ) and postherpetic neuralgia (PHN) and safety of recombinant zoster vaccine (RZV) in adults aged ≥50 years with rheumatoid arthritis (RA).

Methods: VE was assessed using a retrospective matched cohort analysis of Kaiser Permanente Southern California members aged ≥50 years with RA receiving 2 RZV doses (≥4 weeks apart) and matched up to 1:3 to RZV-unvaccinated individuals. Stratified Cox proportional hazards regression was used to estimate adjusted hazard ratios and VE against HZ and PHN.

Spectrum of kidney pathological patterns and association with clinical characteristics in patients with increased serum creatinine in a single Chinese centre.

Our objective was to clarify the pathological characteristics of native kidney biopsies and their association with clinical findings in patients with increased serum creatinine. Patients with elevated serum creatinine at native renal biopsy were included. Demographics, clinical details, and pathological findings of kidney biopsies were collected.

Corticosteroid premedication on anti-tumor effect of immune checkpoint blockade in murine hepatocellular carcinoma models.

Background And Aims: Corticosteroid is effective in alleviating immune-related adverse events (irAEs) of immune checkpoint blockade (ICB). However, prophylactic use of corticosteroid to prevent irAEs is not recommended due to a looming concern that it may attenuate anti-tumor effect of ICB. This study aims to investigate whether corticosteroid premedication may compromise anti-tumor efficacy of dual ICB, a regimen that may cause significant irAEs.

acanthocephaliasis in a paediatric patient.

Acanthocephala are known as thorny-headed worms and are common parasites in animals, but acanthocephaliasis in humans is rare, with limited medical literature available. Infections are acquired via direct ingestion of arthropod intermediate hosts. In this case report, a female toddler is evaluated for passage of a pseudosegmented worm in the stool, which was later identified as She is treated with pyrantel pamoate with a resolution of worms in stool.

Nano Sim@ZIF8@PDA modified injectable temperature sensitive nanocomposite hydrogel for photothermal/drug therapy for peri-implantitis.

Dental implant restoration has become one of the most important treatments for missing teeth. However, peri-implantitis is a common complication of implant restorations, and lack of timely and effective treatment will most likely lead to implant failure. Here, we developed a chitosan-based multifunctional temperature-sensitive hydrogel.

The Effect of Repeated Closing Torque on Torque Loss and Angular Deviation : An in Vitro Study.

Unlabelled: Information. Loosening and fracturing of the central screw are common mechanical complications after implant restoration. However, the relationship between these complications and the repetitive tightening and loosening of the central screw during the fabrication and maintenance of the implant-supported restorations remains unknown.

Enriched environment improves memory function by promoting synaptic remodeling in vascular dementia rats.

Vascular dementia (VaD), attributed to cerebrovascular pathology, is a leading cause of cognitive decline, characterized by memory loss, bradyphrenia, and affective lability, with memory deficits being particularly pronounced. The potential of enriched environment (EE) to ameliorate cognitive impairments by enhancing hippocampal synaptic plasticity, neurogenesis, and white matter remodeling has garnered considerable interest. In this study, we used a rat model for VaD through the procedure of bilateral common carotid artery ligation (BCCAO).

A simple clustering approach to map the human brain's cortical semantic network organization during task.

Constructing task-state large-scale brain networks can enhance our understanding of the organization of brain functions during cognitive tasks. The primary goal of brain network partitioning is to cluster functionally homogeneous brain regions. However, a brain region often serves multiple cognitive functions, complicating the partitioning process.

Prok2/PKR signaling regulates ferroptosis after spinal cord injury.

Spinal cord injury (SCI) is a severe traumatic condition that often results in significant disability and death. SCI also causes secondary damage in the acute phase due to neuronal cell death. SCI has been linked to ferroptosis, a new type of cell death.

Systematic druggable genome-wide Mendelian randomization to identify therapeutic targets and dominant flora for ulcerative colitis.

The relationship and mechanism among gut microbiota (GM), metabolites and active ulcerative colitis (UC) are unclear. This study aims to infer the causal relationship between druggable-genes and active UC using Mendelian randomization (MR) and bioinformatics methods. The "microbiota-target" and "microbiota- metabolite" network was constructed to screen the microorganisms and metabolites associated with active UC, and the mechanism of GM, metabolites and active-UC was analyzed.

Regulation of the EGFR/PI3K/AKT signaling cascade using the Shengui Yangrong Decoction improves ovulation dysfunction and insulin resistance in polycystic ovary syndrome.

Shengui Yangrong Decoction (SGYR) is a traditional Chinese herbal prescription that has been used for the treatment of polycystic ovary syndrome (PCOS). However, there is a consensus on the clinical efficacy of SGYR in treating PCOS, yet the underlying pharmacological mechanisms remain unclear.This study aim to investigate the effects of SGYR on insulin resistance in rats with PCOS and its modulation of follicular development through the epidermal growth factor receptor (EGFR)/PI3K/AKT signaling cascade by integrating metabolomics and network pharmacology and in vivo and in vitro experimental validation.

Detection of Treponema pallidum DNA for diagnosis, resistance identification, and treatment outcome prediction in early syphilis among men who have sex with men.

Objectives: We investigated the use of Treponema pallidum DNA (TP-DNA) for diagnosis, resistance identification, and treatment outcome prediction in early syphilis among men who have sex with men (MSM).

Methods: MSM seeking care for sexually transmitted infections were prospectively enrolled from September 2021 to August 2024. Oral rinse, rectal swab, and urethral swab samples were tested for TP-DNA.

Therapeutic targets in aging-related osteoarthritis: A focus on the extracellular matrix homeostasis.

Osteoarthritis (OA) represents a globally prevalent degenerative bone diseases and is the primary contributors to pain and disability among middle-aged and elderly people, thereby imposing significant social and economic burdens. When articular cartilage is in the aging environment, epigenetic modifications, DNA damage and mitochondrial dysfunction lead to cell senescence. Chondrocyte senescence has been identified as a pivotal event in this metabolic dysregulation of the extracellular matrix (ECM).

Macrophage phenotypes modulate neoangiogenesis and fibroblast profiles in synovial-like organoid cultures.

Objective: To investigate the interaction among the cells thought to be foundational to inflammation, fibrosis, and angiogenesis in the synovial membrane.

Method: We encapsulated fibroblasts, polarized macrophages, and endothelial cells in a 3D culture system. We used this model to determine the cellular transcriptional profiles, cytokine secretion, and vascular formation associated with different macrophage phenotype conditions.

Biowaste ligninsulfonate functionalized cathode of lithium-sulfur battery for immobilization and catalyzation of polysulfides.

Lithium‑sulfur batteries (LSBs) have been appealing an increasing attention in last ten years with the overwhelming advantages of greatly higher theoretical energy density and specific capacity in comparison with traditional Li-ion batteries (LIBs). However, the commercial application of LSBs still confronts some intractable challenges, of which the shuttle effect and sluggish redox kinetics are reckoned as the most serious obstacles. Incorporation of polar sulfonate groups into cathode has been believed as an effective avenue to immobilize polysulfides and thus enables to alleviate the shuttle effect.