Publications by authors named "Chenwei Tian"

Article Synopsis
  • FIGHT-102 was a phase 1 study that examined the safety and preliminary effectiveness of pemigatinib in Japanese patients with advanced solid tumors, focusing on various dosage levels.
  • A total of 44 patients participated, with the most common cancers being cholangiocarcinoma and esophageal cancer; notable side effects included hyperphosphatemia and dysgeusia.
  • Results showed some patients experienced partial responses, and the median duration of response was approximately 9.56 months, suggesting pemigatinib has manageable side effects and potential efficacy for this patient group.
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Polar cell growth is a process that couples the establishment of cell polarity with growth and is extremely important in the growth, development, and reproduction of eukaryotic organisms, such as pollen tube growth during plant fertilization and neuronal axon growth in animals. Pollen tube growth requires dynamic but polarized distribution and activation of a signaling protein named ROP1 to the plasma membrane three processes: positive feedback and negative feedback regulation of ROP1 activation and its lateral diffusion along the plasma membrane. In this paper, we introduce a mechanistic integro-differential equation (IDE) along with constrained semiparametric regression to quantitatively describe the interplay among these three processes that lead to the polar distribution of active ROP1 at a steady state.

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A reaction-diffusion model is proposed to describe the mechanisms underlying the spatial distributions of ROP1 and calcium on the pollen tube tip. The model assumes that the plasma membrane ROP1 activates itself through positive feedback loop, while the cytosolic calcium ions inhibit ROP1 via a negative feedback loop. Furthermore it is proposed that lateral movement of molecules on the plasma membrane are depicted by diffusion.

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