The Facile Preparation of PBA-GO-CuO-Modified Electrochemical Biosensor Used for the Measurement of α-Amylase Inhibitors' Activity.

Element doping and nanoparticle decoration of graphene is an effective strategy to fabricate biosensor electrodes for specific biomedical signal detections. In this study, a novel nonenzymatic glucose sensor electrode was developed with copper oxide (CuO) and boron-doped graphene oxide (B-GO), which was firstly used to reveal rhubarb extraction's inhibitive activity toward α-amylase. The 1-pyreneboronic acid (PBA)-GO-CuO nanocomposite was prepared by a hydrothermal method, and its successful boron doping was confirmed by transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS), in which the boron doping rate is unprecedentedly up to 9.

Discovery, Topo I inhibitory activity and mechanism evaluation of two novel cytisine-type alkaloid dimers from the seeds of Sophora alopecuroides L.

Alopecurosines A and B (CMs 1 and 2, respectively) are two novel cytisine-type alkaloid dimers first isolated from the aerial parts of Sophora alopecuroides L. CMs 1 and 2 are new dimeric alkaloids whose piperidine matrine ring is cleaved and connected via the N'-1 bond. Their chemical structures have been confirmed by IR, UV, HR-ESI-MS, and NMR.