Publications by authors named "Chentao Ding"
Structural determinants of parabens in inhibiting human and rat gonadal 3β-hydroxysteroid dehydrogenase.
Toxicol Appl Pharmacol
November 2024
This study delved into the impacts of 10 parabens on the activity of human and rat gonadal 3β-hydroxysteroid dehydrogenase (3β-HSD) within human KGN cell and rat testicular microsomes, as well as on the secretion of progesterone in KGN cells and the inhibitory potency was compared between human and rats. Intriguingly, the outcomes revealed that ethyl, propyl, butyl, hexyl, heptyl, nonyl, phenyl, and benzyl parabens displayed varying IC values for human 3β-HSD2, from 4.15 to 139.
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- Parabens, used as preservatives in personal care products and pharmaceuticals, were studied for their effects on the enzyme SRD5A1, which converts testosterone to dihydrotestosterone in human and rat brain cells.
- The study found that various parabens inhibited SRD5A1, with nonylparaben showing the strongest inhibitory effect, ultimately reducing dihydrotestosterone production in glioblastoma cells.
- While rat SRD5A1 was less affected by parabens, both human and rat versions showed that these compounds bind to a specific site on the enzyme, indicating significant implications for hormone production and regulation.