Assembly of Selenadiazine Scaffolds via Rh(III)-Catalyzed Amidine-Directed Cascade C-H Selenylation/[5 + 1] Annulation with Elemental Selenium.

By employing elemental selenium as the selenium source, we have realized the amidine-directed Rh(III)-catalyzed cascade C-H selenylation/[5 + 1] annulation for the direct construction of structurally novel selenadiazine, benzoselenadiazine, and benzoselenazol-3-amine frameworks with specific site selectivity and good functional group tolerance. Besides, the obtained products can serve as fundamental platforms for subsequent chemical transformations, and thus, the feasible SeNEx reaction, SeNEx/Michael addition, and simple conversion of the selenadiazine product into diverse other organoselenium molecules were demonstrated accordingly. Taken together, the developed methodology efficiently expands the chemical space of organoselenium species.

The Association of Epicardial Adipose Tissue Volume and Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy: As Assessed by Cardiac MR.

Background: Epicardial adipose tissue (EAT) is a metabolically active visceral fat linked to cardiovascular disease. Prior studies demonstrated the predictive value of EAT volume (EATV) in atrial fibrillation (AF) among hypertrophic obstructive cardiomyopathy patients.

Purpose: To investigate the association between EATV and AF in hypertrophic cardiomyopathy (HCM).

Impact of calcium ions at physiological concentrations on the adsorption behavior of proteins on silica nanoparticles.

The adsorption of proteins on nanoparticles (NPs) largely decides the fate and bioeffects of NPs in vivo. However, bio-fluids are too complicated to directly study in them to reveal related mechanisms, and current studies on model systems often ignore some important biological factors, such as metal ions. Herein, we evaluate the effect of Ca at physiological concentrations on the protein adsorption on negatively-charged silica NP (SNP50).

Exocytosis of Nanoparticles: A Comprehensive Review.

Both biomedical applications and safety assessments of manufactured nanomaterials require a thorough understanding of the interaction between nanomaterials and cells, including how nanomaterials enter cells, transport within cells, and leave cells. However, compared to the extensively studied uptake and trafficking of nanoparticles (NPs) in cells, less attention has been paid to the exocytosis of NPs. Yet exocytosis is an indispensable process of regulating the content of NPs in cells, which in turn influences, even decides, the toxicity of NPs to cells.

Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells.

Nanoplastics, one component of plastic pollution, can enter human bodies via inhalation and thus threaten human health. However, the knowledge about the uptake and exocytosis of nanoplastics in cells of human lung organs is still very limited. Herein, we investigated the endocytosis, distribution, and exocytosis of polystyrene nanoparticles (PS NPs) of 50 nm (G50PS) and 100 nm (R100PS) in A549 cells and BEAS-2B cells.

Silicene/boron nitride heterostructure for the design of highly efficient anode materials in lithium-ion battery.

The performance of silicene/boron nitride heterostructure as anode material in lithium-ion batteries (LIBs) has been investigated by first-principles calculations. From the interfacial synergy effect, an enhanced adsorption of Li ions on BN is found in the resulted heterostructure compared with pristine BN system. Also, lowered diffusion barriers are found in the BN/Li/silicene and BN/silicene/Li systems compared with pristine silicene system.

Phenotypic characterization of CADASIL patients with the Arg332Cys mutation in the .

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary vascular disease caused by mutations in , that are primarily localized in exons 4, 3, and 11. The Arg332Cys mutation in exon 6 has been rarely reported in patients with CADASIL.

Methods: A case study and the results of a comprehensive systemic search of the PubMed database, using the keywords "CADASIL", "Arg332Cys", "R332C", and "exon 6", are reported.

A case report of paravertebral low-grade malignant fibrous myxoid sarcoma.

Rationale: Low-grade malignant fibrous myxoid sarcoma (LGFMS) is a malignant tumor that originates from soft tissues and has specific clinical and histopathological characteristics. Paravertebral LGFMS is rarely reported.

Patient Concerns: A 60-year-old woman had pain in the lower back and right anterior thigh for more than 3 years.

The driving force of prophages and CRISPR-Cas system in the evolution of Cronobacter sakazakii.

Cronobacter sakazakii is an important foodborne pathogens causing rare but life-threatening diseases in neonates and infants. CRISPR-Cas system is a new prokaryotic defense system that provides adaptive immunity against phages, latter play an vital role on the evolution and pathogenicity of host bacteria. In this study, we found that genome sizes of C.